4. Ishiwata T, Kudo M, Onda M, Fujii T, Teduka K, Suzuki T, Korc M, Naito Z: Defined localization of nestin-expressing cells in L-arginine-induced acute pancreatitis. Pancreas 32: 360-368,2006

1. Kurban G, Ishiwata T, Kudo M, Yokoyama M, Sugisaki Y, Naito Z: Expression of keratinocyte growth factor receptor (KGFR/FGFR2 IIIb) in human uterine cervical cancer. Oncology Rep 11:987-991,2004

2. Ishiwata T, Naito Z, Fujii T, Ishiwata S,Ikegawa S:　Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells. Pathol Int 54: 77-81, 2004

3. Xu G, Takashi E, Kudo M, Ishiwata T, Naito Z: Contradictory effects of short- and long-term hyperglycemias on ischemic injury of myocardium via intracellular signaling pathway. Exp Mol Pathol 76: 57-65, 2004

4.Niggemann P, Murata S, Naito Z, Kumazaki T: A comparative study of the microcirculatory changes in the developing liver cirrhosis between the central and peripheral parts of the main lobe in mice. Hepatol Res 28:41-48, 2004

5.Maeda S, Hosone M, Katayama H, Azuma K, Yokota A, Nakai A, Liu A, Naito Z: Deciduoid mesothelioma in the pelvic cavity. Pathol Int 54:67-72, 2004

6.Kusafuka K, Ishiwata T, Sugisaki Y, Takemura T, Kusafuka M, Hisha H, Ikehara S: Lumican expression is associated with the formation of mesenchyme-like elements in salivary pleomorphic adenomas. J Pathol 203: 953-960, 2004

7.Ishiwata S, Ozawa Y, Katayama J, Kaneko S, Shindo H, Tomioka Y, Ishiwata T, Asano G, Ikegawa S, Mizugaki M: Elevated expression level of 60-kDa subunit of tRNA-guanine transglycosylase in colon cancer. Cancer Lett 212: 113-119, 2004

8.Kawano Y, Tajiri T, Akimaru K, Tokunaga A, Uchida E, Yoshiyuki T, Yoshida H, Mamada Y, Taniai N, Shinji S, Naito Z: A case report of duodenal carcinoid tumor associated with early gastric cancer. J Nippon Med Sch. 71: 198-202, 2004

9.Kitagawa Y, Ito H, Sawaizumi T, Matsubara M, Yokoyama M, Naito Z, Maeda S, Sugisaki Y: Fine needle aspiration cytology of primary epithelioid sarcoma. A report of 2 cases. Acta Cytol 48: 391-396, 2004

〔2003年〕

1. Sun Y, Naito Z, Ishiwata T, Maeda S, Sugisaki Y, Asano G: Basic FGF and Ki-67 proteins useful for immunohistological diagnostic evaluations in malignant solitary fibrous tumor. Pathol Int 53:284-290, 2003

2. Saika S, Miyamoto T, Tanaka S, Tanaka T, Ishida I, Ohnishi Y, Ooshima A, Ishiwata T, Asano G, Chikama T, Shiraishi A, Liu CY, Kao CW, Kao WW: Response of lens epithelial cells to injury: role of lumican in epithelial-mesenchymal transition. Invest Ophthalmol Vis Sci 44:2094-2102, 2003

3. Onda M, Naito Z, Wang R, Fujii T, Kawahara K, Ishiwata T, Sugisaki Y: Expression of keratinocyte growth factor receptor (KGFR/FGFR2 IIIb) in vascular smooth muscle cells. Pathol Int 53:127-132, 2003

4. Naito Z, Takashi E, Xu G, Ishiwata T, Teduka K, Yokoyama M, Yamada N, Sugisaki Y, Asano G: Different influences of hyperglycemic duration on phosphorylated extracellular signal-regulated kinase 1/2 in rat heart. Exp Mol Pathol 74:23-32, 2003

5. Naito Z, Ishiwata T, Lu YP, Teduka K, Fujii T, Kawahara K, Sugisaki Y: Transient and ectopic expression of lumican by acinar cells in L-arginine-induced acute pancreatitis. Exp Mol Pathol 74:33-39, 2003

6. Kudo M, Wang Y, Wani MA, Xu M, Ayub A, Ashraf M: Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J Mol Cell Cardiol 35:1113-1119, 2003

7. Asano G, Takashi E, Ishiwata T, Onda M, Yokoyama M, Naito Z, Ashraf M, Sugisaki Y: Pathogenesis and protection of ischemia and reperfusion injury in myocardium. J Nippon Med Sch 70:384-392, 2003

8.Shinji S, Ishiwata T, Tajiri T, Tanaka N, Seya T, Kawahara K, Yokoyama M, Naito Z: External whole-body image of EGFP gene expression. J Nippon Med Sch 70:462-463, 2003

9.Kitagawa Y, Ito H, Sawaizumi T, Matsubara M, Yokoyama M, Naito Z: Fine needle aspiration cytology for soft tissue tumours of the hand. J Hand Surg [Br] 28:582-585, 2003

10.Kato S, Tajiri T, Matsukura N, Matsuda N, Taniai N, Mamada H, Yoshida H, Kiyam T, Naito Z: Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. Scand J Gastroenterol 38:886-893, 2003

11.Tanaka-Nozaki M, Tajiri T, Tanaka N, Furukawa K, Takasaki H, Yoshimura K, Suzuki H, Naito Z, Sugizaki Y, Merk HF, Blomeke B, Kato S: Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival. Oncol Rep 10:1425-1429, 2003

12.進士誠一、田尻　孝、宮下正夫、古川清憲、高崎秀明、源河敦史、佐々木順平、田中宣威、内藤善哉：腹壁瘢痕ヘルニア破裂の一例. 日本腹部救急医学会雑誌23: 815-819, 2003

〔2002年〕

1. Ishiwata T, Naito Z, Lu YP, Kawahara K, Fujii T, Kawamoto Y, Teduka K, Sugisaki Y: Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis. Exp Mol Pathol 73:181-190, 2002

2. Wauke K, Nagashima M, Ishiwata T, Asano G, Yoshino S: Expression and localization of vascular endothelial growth factor-C in rheumatoid arthritis synovial tissue. J Rheumatol 29:34-38, 2002

3. Sawada N, Ishiwata T, Naito Z, Maeda S, Sugisaki Y, Asano G: Immunohistochemical localization of endothelial cell markers in solitary fibrous tumor. Pathol Int 52:769-776, 2002

4. Ping Lu Y, Ishiwata T, Asano G: Lumican expression in alpha cells of islets in pancreas and pancreatic cancer cells. J Pathol 196:324-330, 2002

5. Onda M, Ishiwata T, Kawahara K, Wang R, Naito Z, Sugisaki Y: Expression of lumican in thickened intima and smooth muscle cells in human coronary atherosclerosis. Exp Mol Pathol 72:142-149, 2002

6. Naito Z, Ishiwata T, Kurban G, Teduka K, Kawamoto Y, Kawahara K, Sugisaki Y: Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests. Int J Oncol 20:943-948, 2002

7. Nagashima M, Tanaka H, Takahashi H, Tachihara A, Tanaka K, Ishiwata T, Asano G, Yoshino S: Study of the mechanism involved in angiogenesis and synovial cell proliferation in human synovial tissues of patients with rheumatoid arthritis using SCID mice. Lab Invest 82:981-988, 2002

8. Nagae Y, Kameyama K, Yokoyama M, Naito Z, Yamada N, Maeda S, Asano G, Sugisaki Y, Tanaka S: Expression of E-cadherin catenin and C-erbB-2 gene products in invasive ductal-type breast carcinomas. J Nippon Med Sch 69:165-171, 2002

9. Lu YP, Ishiwata T, Kawahara K, Watanabe M, Naito Z, Moriyama Y, Sugisaki Y, Asano G: Expression of lumican in human colorectal cancer cells. Pathol Int 52:519-526, 2002

10. Kornmann M, Ishiwata T, Matsuda K, Lopez ME, Fukahi K, Asano G, Beger HG, Korc M: IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells. Gastroenterology 123:301-313, 2002

11. Hirose Y, Naito Z, Kato S, Onda M, Sugisaki Y: Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody. J Nippon Med Sch 69:243-251, 2002

12. Kudo M, Wang Y, Xu M, Ayub A, Ashraf M: Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway. Am J Physiol Heart Circ Physiol 283:H296-301, 2002

13.Uchida E, Tajiri T, Nakamura Y, Aimoto T, Naito Z: Relationship between grade of fibrosis in pancreatic stump and postoperative pancreatic exocrine activity after pancreaticoduodenectomy: with special reference to insufficiency of pancreaticointestinal anastomosis. J Nippon Med Sch 69:549-556, 2002

〔2001年〕
1. Wang R, Kudo M, Yokoyama M, Asano G: Roles of advanced glycation endproducts (AGE) and receptor for AGE on vascular smooth muscle cell growth. J Nippon Med Sch 68:472-481, 2001

2. Yano M, Hirai K, Naito Z, Yokoyama M, Ishiwata T, Shiraki Y, Inokuchi M, Asano G: Expression of cathepsin B and cystatin C in human breast cancer. Surg Today 31:385-389, 2001

3. Qin H, Ishiwata T, Asano G: Effects of the extracellular matrix on lumican expression in rat aortic smooth muscle cells in vitro. J Pathol 195:604-608, 2001

4. Obara K, Yokoyama M, Asano G, Tanaka S: Evaluation of myc and chromosome 8 copy number in colorectal cancer using interphase cytogenetics. Int J Oncol 18:233-239, 2001

5. Naito Z, Nishigaki R, Kawahara K, Yokoyama M, Yamada N, Asano G, Shimizu-Suganuma M, Shichinohe K: Localization of extracellular matrix and mitogen-activated protein kinase (MAPK) in aorta of streptozotocin treated Mongolian gerbils. J Nippon Med Sch 68:37-44, 2001

6. Nagashima M, Hasegawa J, Kato K, Yamazaki J, Nishigai K, Ishiwata T, Asano G, Yoshino S: Hepatocyte growth factor (HGF), HGF activator, and c-Met in synovial tissues in rheumatoid arthritis and osteoarthritis. J Rheumatol 28:1772-1778, 2001

7. Matsuike A, Ishiwata T, Watanabe M, Asano G: Expression of fibroblast growth factor (FGF)-10 in human colorectal adenocarcinoma cells. J Nippon Med Sch 68:397-404, 2001

8. Masuda Y, Shimizu A, Mori T, Ishiwata T, Kitamura H, Ohashi R, Ishizaki M, Asano G, Sugisaki Y, Yamanaka N: Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. Am J Pathol 159:599-608, 2001

9. Liu AM, Maeda S, Hosone M, Azuma K, Katayama H, Yokoyama M, Naito Z, Sugisaki Y, Asano G: Use of electron microscopic evaluation for the diagnosis of adrenal cortical carcinoma in fine needle aspiration cytology: a case report and review of the literature. Med Electron Microsc 34:190-197, 2001

10. Li X, Maeda S, Hosone M, Katayama H, Sawada N, Sun Y, Ishiwata T, Yokoyama M, Naito Z, Asano G: Expression and localization of basic fibroblast growth factor and its mRNA in solitary fibrous tumor. J Nippon Med Sch 68:384-392, 2001

11. Imai J, Ghazizadeh M, Naito Z, Asano G: Immunohistochemical expression of T, Tn and sialyl-Tn antigens and clinical outcome in human breast carcinoma. Anticancer Res 21:1327-1334, 2001

12. Hasegawa H, Onda M, Matsukura N, Naito Z, Maruyama H, Tokunaga A: Hemorrhagic gastric carcinoma in an acromegalic patient. J Nippon Med Sch 68:266-270, 2001

13. Baba H, Ishiwata T, Takashi E, Xu G, Asano G: Expression and localization of lumican in the ischemic and reperfused rat heart. Jpn Circ J 65:445-450, 2001

14. Wang Y, Kudo M, Xu M, Ayub A, Ashraf M: Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. J Mol Cell Cardiol 33:2037-2046, 2001

〔2000年〕

1. Zhang J, You H, Wang T, Wang B, Jia J, Katayama H, Maeda S, Wang R, Asano G, Ishiwata T, Naito Z, Yokoyama M: Triple-staining to identify apoptosis of hepatic cells in situ. J Nippon Med Sch 67:280-283, 2000

2. Yoshioka T, Nakajima A, Akiba H, Ishiwata T, Asano G, Yoshino S, Yagita H, Okumura K: Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur J Immunol 30:2815-2823, 2000

3. Watanabe M, Ishiwata T, Nishigai K, Moriyama Y, Asano G: Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer. Pathol Int 50:363-372, 2000

4. Ogata M, Naito Z, Tanaka S, Moriyama Y, Asano G: Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma. J Nippon Med Sch 67:177-185, 2000

5. Qin H, Ishiwata T, Wang R, Kudo M, Yokoyama M, Naito Z, Asano G: Effects of extracellular matrix on phenotype modulation and MAPK transduction of rat aortic smooth muscle cells in vitro. Exp Mol Pathol 69:79-90, 2000

6. Naito Z, Kudo M, Xu G, Nishigaki R, Yokoyama M, Yamada N, Asano G: Immunohistochemical localization of mitogen-activated protein kinase (MAPK) family and morphological changes in rat heart after ischemia-reperfusion injury. Med Electron Microsc 33:74-81, 2000

7. Lu YP, Nishigai K, Ishiwata T, Asano G: Differential expression of hepatocyte growth factor and its receptor (c-Met) in a rat artificial anus model. Wound Repair Regen 8:59-67, 2000

8. Kornmann M, Ishiwata T, Maruyama H, Beger HG, Korc M: Coexpression of FAS and FAS-ligand in chronic pancreatitis: correlation with apoptosis. Pancreas 20:123-128, 2000

9. Kornmann M, Ishiwata T, Kleeff J, Beger HG, Korc M: Fas and Fas-ligand expression in human pancreatic cancer. Ann Surg 231:368-379, 2000

10. Itakura J, Ishiwata T, Shen B, Kornmann M, Korc M: Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer 85:27-34, 2000
11. Takashi E, Ashraf M: Pathologic assessment of myocardial cell necrosis and apoptosis after ischemia and reperfusion with molecular and morphological markers. J Mol Cell Cardiol 32:209-224, 2000

〔1999年〕

1. Yu H, Yokoyama M, Asano G: Time course of expression and localization of heat shock protein 72 in the ischemic and reperfused rat heart. Jpn Circ J 63:278-287, 1999

2. Yano M, Naito Z, Yokoyama M, Shiraki Y, Ishiwata T, Inokuchi M, Asano G: Expression of hsp90 and cyclin D1 in human breast cancer. Cancer Lett 137:45-51, 1999

3. Tanaka N, Onda M, Seya T, Kanazawa Y, Naito Z, Asano G, Oguro T: Establishment and characterization of a human rectal neuroendocrine carcinoma xenograft into nude mice. Digestion 60:117-124, 1999

4. Nishigaki R, Guo F, Onda M, Yamada N, Yokoyama M, Naito Z, Asano G, Lee WL, Chen JW, Ting CT, Ishiwata T, Lin SJ, Korc M, Wang PH: Insulin-like growth factor I improves cardiovascular function and suppresses apoptosis of cardiomyocytes in dilated cardiomyopathy. Endocrinology 140:4831-4840, 1999

5. Kudo M, Naito Z, Yokoyama M, Asano G: Effects of quercetin and sunphenon on responses of cancer cells to heat shock damage. Exp Mol Pathol 66:66-75, 1999

6. Kleeff J, Maruyama H, Ishiwata T, Sawhney H, Friess H, Buchler MW, Korc M: Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology 116:1202-1216, 1999

7. Kleeff J, Kusama T, Rossi DL, Ishiwata T, Maruyama H, Friess H, Buchler MW, Zlotnik A, Korc M: Detection and localization of Mip-3alpha/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer. Int J Cancer 81:650-657, 1999

8. Kleeff J, Ishiwata T, Maruyama H, Friess H, Truong P, Buchler MW, Falb D, Korc M: The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Oncogene 18:5363-5372, 1999

9. Hirai K, Yokoyama M, Asano G, Tanaka S: Expression of cathepsin B and cystatin C in human colorectal cancer. Hum Pathol 30:680-686, 1999

10. Fujii T, Nishigaki R, Kawahara K, Yamada N, Onda M, Yokoyama M, Naito Z, Asano G, Shimizu-Suganuma M, Shichinohe K: Ultrastructural changes and immunohistochemical localization of advanced glycation end products in the heart of streptozotocin-treated Mongolian gerbils. Med Electron Microsc 32:43-49, 1999

11. Ebert M, Yokoyama M, Ishiwata T, Friess H, Buchler MW, Malfertheiner P, Korc M: Alteration of fibroblast growth factor and receptor expression after acute pancreatitis in humans. Pancreas 18:240-246, 1999

12. Asano G, Wang R, Kameyama K, Yamada N, Onda M, Naito Z, Yokoyama M: Risk factors and pathogenesis of atherosclerotic lesion. Nippon Ika Daigaku Zasshi 66:372-381, 1999

13. Takashi E, Wang Y, Ashraf M: Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway. Circ Res 85:1146-1153, 1999

平成１５、16年度
日本学術振興会　科学研究費（基盤C）
　　研究課題名：β-細胞への分化能を有する膵内外のprogenitor cellの同定とその応用

平成１５年
Best Abstract Award of 11th United European Gastroenterology Week(Madrid,Spain)
題名：Lumican expression in human carcinoid

平成１４、15年度
日本学術振興会　科学研究費（基盤C）
　　研究課題名：膵癌、随伴性膵炎におけるLumicanの役割と応用

平成14年度、15年度
日本学術振興会　科学研究費（基盤C）
　　研究課題名：線維芽細胞増殖因子(FGF)-7とFGF-10による膵組織再生誘導の研究

平成１３年度、１４年度
日本学術振興会　科学研究費（基盤C）
　　研究課題名：慢性膵炎における線維芽細胞増殖因子（FGF）-10の発現と役割

平成１２年度　
Travel award of combined meeting of international pancreatic　meeting　and American pancreatic association
　　題名：Expression and localization of lumican in human pancreatic cancer

平成10年度、11年度
科学研究費　（奨励研究A）
　　研究課題名：糖尿病症例の動脈硬化病変内のAGE化自家蛍光物質の化学組成分析および 構造解析