{"id":111,"date":"2025-09-26T18:54:41","date_gmt":"2025-09-26T09:54:41","guid":{"rendered":"https:\/\/www.nms.ac.jp\/college\/?page_id=111"},"modified":"2026-03-21T16:37:30","modified_gmt":"2026-03-21T07:37:30","slug":"taisya-eiyougaku","status":"publish","type":"page","link":"https:\/\/www.nms.ac.jp\/college\/department\/kisoigaku\/taisya-eiyougaku\/","title":{"rendered":"\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09"},"content":{"rendered":"<section>\r\n  <div class=\"inner\">\r\n    <!-- <h3 class=\"pagettl u-ta-l\">\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09<\/h3> -->\r\n    <div>\r\n      <div class=\"prof\">\r\n        <p>\r\n          \u79c1\u305f\u3061\u306e\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09\u6559\u5ba4\uff08\u65e7\u751f\u5316\u5b66\u7b2c\u4e00\u8b1b\u5ea7\uff09\u306f\u30011936\u5e74\u306e\u5275\u7acb\u4ee5\u676580\u5e74\u4ee5\u4e0a\u306b\u4e98\u308a\u3001\u591a\u304f\u306e\u6307\u5c0e\u7684\u306a\u751f\u5316\u5b66\u8005\u3092\u8f29\u51fa\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u81e8\u5e8a\u304b\u3089\u5927\u5b66\u9662\u751f\u30fb\u7814\u7a76\u751f\u3092\u53d7\u3051\u5165\u308c\u3001\u512a\u308c\u305f\u81e8\u5e8a\u7814\u7a76\u8005\u3092\u80b2\u3066\u3066\u304d\u305f\u4f1d\u7d71\u3042\u308b\u6559\u5ba4\u3067\u3059\u3002\r\n          <br><br>\u3053\u306e\u9577\u3044\u6b74\u53f2\u306e\u4e2d\u3067\u3001\u5f53\u6559\u5ba4\u306f\u751f\u5316\u5b66\u9818\u57df\u306b\u304a\u3051\u308b\u57fa\u76e4\u7684\u304b\u3064\u5fdc\u7528\u7684\u306a\u8ab2\u984c\u306b\u53d6\u308a\u7d44\u3080\u3079\u304f\u3001\u4e00\u8cab\u3057\u3066\u86cb\u767d\u8cea\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3001\u86cb\u767d\u8cea\u76f8\u4e92\u4f5c\u7528\u3001\u5148\u5929\u6027\u4ee3\u8b1d\u7570\u5e38\u75c7\u306e\u539f\u56e0\u89e3\u660e\u3092\u8ef8\u306b\u3001\u591a\u304f\u306e\u56fd\u5185\u5916\u5171\u540c\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u5f53\u6559\u5ba4\u304c\u91cd\u70b9\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u305f\u4ee3\u8868\u7684\u7814\u7a76\u3068\u3057\u3066\u3001\uff081\uff09\u5148\u5929\u6027\u9aa8\u7cfb\u7d71\u75be\u60a3\u3067\u3042\u308b\u4f4e\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u75c7\u306b\u304a\u3051\u308b\u9aa8\u77f3\u7070\u5316\u969c\u5bb3\u306e\u5206\u5b50\u57fa\u76e4\u89e3\u660e\u3001\uff082\uff09\u91d1\u5c5e\u9175\u7d20\u304c\u95a2\u308f\u308b\u30ec\u30c9\u30c3\u30af\u30b9\u5fae\u7d30\u69cb\u9020\u6a5f\u80fd\u89e3\u6790\u3068\u5b89\u5b9a\u540c\u4f4d\u4f53\u30a2\u30df\u30ce\u9178\u30e9\u30d9\u30eb\u5c0e\u5165\u7528\u306e\u65b0\u898f\u5927\u8178\u83cc\u767a\u73fe\u5bbf\u4e3b\u682a\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u958b\u767a\u30fb\u516c\u958b\u3001\uff083\uff09\u75db\u98a8\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20\uff08Xanthine\r\n          Oxidoreductase;\r\n          XOR\uff09\u306b\u3088\u308b\u89e6\u5a92\u53cd\u5fdc\u30fb\u6d3b\u6027\u9178\u7d20\u7523\u751f\u6a5f\u69cb\u3001\u85ac\u5264\u7d50\u5408\u578b\u69cb\u9020\u306e\u89e3\u660e\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u7279\u306b\u3001XOR\u7814\u7a76\u306f\u6297\u75db\u98a8\u85ac\u3067\u3042\u308b\u30d5\u30a7\u30d6\u30ea\u30af\u3068\u30c8\u30d4\u30ed\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u3063\u305f\u793e\u4f1a\u7684\u306b\u3082\u30a4\u30f3\u30d1\u30af\u30c8\u306e\u5927\u304d\u3044\u7814\u7a76\u3067\u3059\u3002\u3044\u305a\u308c\u306e\u30c6\u30fc\u30de\u3082\u3001\u751f\u547d\u73fe\u8c61\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3001\u57fa\u790e\u751f\u5316\u5b66\u306e\u8996\u70b9\u3092\u8d77\u70b9\u3068\u3057\u3064\u3064\u3001\u30d2\u30c8\u75be\u60a3\u306e\u7406\u89e3\u3084\u3053\u308c\u3089\u306b\u5bfe\u3059\u308b\u6709\u52b9\u306a\u65b0\u898f\u6cbb\u7642\u30fb\u4e88\u9632\u6cd5\u306e\u958b\u767a\u3078\u3068\u3064\u306a\u304c\u308b\u9ad8\u3044\u6ce2\u53ca\u6027\u3092\u6301\u3064\u3082\u306e\u3067\u3059\u30022018\u5e74\u3088\u308a\u3001\u524d\u4efb\u306e\u5927\u77f3\u7531\u7f8e\u5b50\u6559\u6388\u3092\u4e2d\u5fc3\u306b\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u57fa\u76e4\u3092\u7d99\u627f\u30fb\u767a\u5c55\u3055\u305b\u3064\u3064\u3001\u73fe\u4ee3\u533b\u7642\u304c\u76f4\u9762\u3059\u308b\u52a0\u9f62\u95a2\u9023\u75be\u60a3\u3084\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u304c\u5c55\u958b\u3055\u308c\u3001\u9ad8\u5ea6\u30aa\u30df\u30af\u30b9\u89e3\u6790\u3084\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306a\u3069\u306e\u5148\u9032\u6280\u8853\u3092\u7528\u3044\u3001\u4ee3\u8b1d\u6052\u5e38\u6027\u306e\u7834\u7dbb\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u3053\u308c\u3089\u306e\u75be\u60a3\u767a\u75c7\u306b\u7d50\u3073\u3064\u304f\u306e\u304b\u304c\u7814\u7a76\u3055\u308c\u307e\u3057\u305f\u3002\r\n        <\/p>\r\n        <div class=\"prof-info\">\r\n          <img decoding=\"async\" src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/img_prof.png\" alt=\"\u4f50\u85e4 \u5353\">\r\n          <p class=\"txt\">\r\n            \u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66(\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66) \/ <br>\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66<br>\u5927\u5b66\u9662\u6559\u6388\u3000\r\n            <span class=\"name\">\u4f50\u85e4 \u5353<\/span>\r\n          <\/p>\r\n        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n    <div class=\"u-mt-40 u-mt-sp-30\">\r\n      <p>\r\n        2023\u5e7410\u6708\u3088\u308a\u4f50\u85e4\u304c\u5f53\u6559\u5ba4\u306e\u4e3b\u5bb0\u3092\u5f15\u304d\u7d99\u304e\u3001\u65b0\u305f\u306a\u7814\u7a76\u30c6\u30fc\u30de\u3068\u3057\u3066\u3001\u30d2\u30c8\u304c\u3093\u306b\u7279\u5316\u3057\u305f\u7814\u7a76\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002\u304c\u3093\u306f\u8a00\u3046\u307e\u3067\u3082\u306a\u304f\u3001\u73fe\u5728\u306b\u304a\u3044\u3066\u3082\u4e16\u754c\u7684\u306a\u4e3b\u8981\u6b7b\u56e0\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u75c7\u3084\u9032\u5c55\u306b\u95a2\u308f\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u3001\u73fe\u4ee3\u533b\u5b66\u306b\u304a\u3051\u308b\u6700\u91cd\u8981\u8ab2\u984c\u306e\u4e00\u3064\u3067\u3059\u3002\u751f\u5316\u5b66\u306f\u3001\u7d30\u80de\u5185\u3067\u8d77\u3053\u308b\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u73fe\u8c61\u3092\u5bfe\u8c61\u3068\u3059\u308b\u5b66\u554f\u3067\u3042\u308a\u3001\u304c\u3093\u3068\u3044\u3046\u8907\u96d1\u306a\u75c5\u614b\u3092\u6839\u672c\u304b\u3089\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u3001\u4e0d\u53ef\u6b20\u306a\u8996\u70b9\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u7d30\u80de\u5897\u6b96\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3001\u3055\u3089\u306b\u306f\u7d30\u80de\u9593\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u3044\u3063\u305f\u3001\u304c\u3093\u306e\u672c\u8cea\u306b\u95a2\u308f\u308b\u751f\u547d\u73fe\u8c61\u306f\u3001\u751f\u5316\u5b66\u7684\u624b\u6cd5\u306b\u3088\u308b\u89e3\u6790\u306a\u3057\u306b\u306f\u5341\u5206\u306b\u8a9e\u308c\u307e\u305b\u3093\u3002\u3068\u308a\u308f\u3051\u8fd1\u5e74\u3067\u306f\u3001\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3084\u3001\u7279\u5b9a\u306e\u4ee3\u8b1d\u9175\u7d20\u306e\u7570\u5e38\u767a\u73fe\u304c\u304c\u3093\u306e\u60aa\u6027\u5316\u3084\u6cbb\u7642\u62b5\u6297\u6027\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u751f\u5316\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u91cd\u8981\u6027\u306f\u304b\u3064\u3066\u306a\u3044\u307b\u3069\u306b\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\r\n        <br><br>\u3053\u3046\u3057\u305f\u80cc\u666f\u3092\u8e0f\u307e\u3048\u3001\u5f53\u6559\u5ba4\u3067\u306f\u304c\u3093\u7814\u7a76\u306b\u304a\u3051\u308b\u751f\u5316\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u3055\u3089\u306a\u308b\u6df1\u5316\u3092\u76ee\u6307\u3057\u3001\u30e6\u30cb\u30fc\u30af\u306a\u7814\u7a76\u8cc7\u6e90\u3068\u3057\u3066\u300c\u60a3\u8005\u7531\u6765\u304c\u3093\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u300d\u3092\u6d3b\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5b9f\u969b\u306e\u60a3\u8005\u306e\u816b\u760d\u7d44\u7e54\u304b\u3089\u6a39\u7acb\u3055\u308c\u305f\u4e09\u6b21\u5143\u57f9\u990a\u304c\u3093\u7d30\u80de\u682a\u3067\u3042\u308a\u3001\u5f93\u6765\u306e\u304c\u3093\u7d30\u80de\u682a\u3068\u6bd4\u3079\u3001\u60a3\u8005\u306e\u816b\u760d\u672c\u6765\u306e\u6027\u8cea\u3092\u8a66\u9a13\u7ba1\u5185\u306b\u5fe0\u5b9f\u306b\u518d\u73fe\u3067\u304d\u308b\u70b9\u304c\u5927\u304d\u306a\u7279\u9577\u3067\u3059\u3002\u3053\u3046\u3057\u305f\u7d30\u80de\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u304c\u3093\u306b\u7279\u6709\u306e\u4ee3\u8b1d\u7d4c\u8def\u306e\u7570\u5e38\u3084\u3001\u85ac\u5264\u8010\u6027\u3092\u5f15\u304d\u8d77\u3053\u3059\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306a\u3069\u3001\u5f93\u6765\u306e\u624b\u6cd5\u3067\u306f\u6349\u3048\u304d\u308c\u306a\u304b\u3063\u305f\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001\u60a3\u8005\u7531\u6765\u304c\u3093\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u6211\u3005\u306e\u6700\u65b0\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b\u7279\u5b9a\u306e\u4ee3\u8b1d\u7d4c\u8def\u306e\u5909\u5316\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u3001\u3053\u308c\u304c\u304c\u3093\u306e\u518d\u767a\u3084\u60a3\u8005\u4e88\u5f8c\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\uff08Nakagawa\r\n        &#038; Sato et al. Commun Biol. 8, 507 (2025), Sase &#038; Sato et al. Dev Cell. 60, 396-413.e6\r\n        (2025)\uff09\u3002\u4eca\u5f8c\u3082\u3053\u3046\u3057\u305f\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u7814\u7a76\u3092\u901a\u3058\u3066\u3001\u304c\u3093\u306e\u672c\u8cea\u306b\u8feb\u308b\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u7406\u89e3\u3092\u9032\u3081\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u69cb\u7bc9\u306b\u3064\u306a\u3052\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\r\n        <br><br>\u672c\u5b66\u306e\u7279\u8272\u306e\u4e00\u3064\u306f\u3001\u81e8\u5e8a\u3068\u57fa\u790e\u7814\u7a76\u3068\u306e\u57a3\u6839\u304c\u4f4e\u304f\u3001\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3068\u306e\u5bc6\u306a\u9023\u643a\u306e\u3082\u3068\u3067\u7814\u7a76\u3092\u9032\u3081\u3089\u308c\u308b\u74b0\u5883\u306b\u3042\u308b\u70b9\u3067\u3059\u3002\u5b9f\u969b\u306e\u81e8\u5e8a\u73fe\u5834\u304b\u3089\u5f97\u3089\u308c\u308b\u77e5\u898b\u3084\u8ab2\u984c\u3092\u7814\u7a76\u306b\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3057\u3001\u57fa\u790e\u306e\u6210\u679c\u3092\u518d\u3073\u81e8\u5e8a\u306b\u9084\u5143\u3059\u308b\u300c\u30d9\u30f3\u30c1\u304b\u3089\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u3078\u3001\u305d\u3057\u3066\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u304b\u3089\u518d\u3073\u30d9\u30f3\u30c1\u3078\u300d\u3068\u3044\u3046\u53cc\u65b9\u5411\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u672c\u5b66\u306a\u3089\u3067\u306f\u306e\u5f37\u307f\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u74b0\u5883\u3067\u884c\u3046\u751f\u5316\u5b66\u7814\u7a76\u306f\u3001\u5358\u306a\u308b\u57fa\u790e\u7684\u77e5\u898b\u306e\u84c4\u7a4d\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u5b9f\u969b\u306e\u304c\u3093\u8a3a\u7642\u306b\u76f4\u7d50\u3059\u308b\u6210\u679c\u3092\u751f\u307f\u51fa\u3059\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\r\n        <br><br>\u6211\u3005\u306f\u4eca\u5f8c\u3082\u3001\u751f\u5316\u5b66\u306e\u8996\u70b9\u304b\u3089\u69d8\u3005\u306a\u75be\u60a3\u306e\u672c\u8cea\u306b\u8feb\u308b\u7814\u7a76\u3092\u3055\u3089\u306b\u63a8\u9032\u3057\u3001\u65b0\u305f\u306a\u8a3a\u65ad\u30fb\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u3068\u3068\u3082\u306b\u3001\u6b21\u4e16\u4ee3\u306e\u7814\u7a76\u8005\u30fb\u533b\u7642\u4eba\u6750\u306e\u80b2\u6210\u306b\u3082\u7a4d\u6975\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u304d\u307e\u3059\u3002\r\n      <\/p>\r\n    <\/div>\r\n    <div class=\"u-mt-80 u-mt-sp-60\">\r\n      <ul class=\"acc-list\">\r\n        <li class=\"accordion\">\r\n          <div class=\"acc-header\">\u4e3b\u306a\u7814\u7a76\u5185\u5bb9<\/div>\r\n          <div class=\"acc-content\">\r\n            <div id=\"sec01\" class=\"sec_base\">\r\n              <h3 class=\"c-ttl\">1. \u60a3\u8005\u7531\u6765\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3067\u6311\u3080\u3000\u30d2\u30c8\u304c\u3093\u306e\u89e3\u660e\u3068\u518d\u767a\u5236\u5fa1<\/h3>\r\n              <p style=\"text-align: right;\">\r\n                <span class=\"color\"><strong>\uff08\u5927\u5b66\u9662\u6559\u6388\u3000\u4f50\u85e4\u3000\u5353\uff09<\/strong><\/span>\r\n              <\/p>\r\n              <p style=\"text-align: center;\">\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u304c\u3093\u6cbb\u7642\u3067\u306f\u96c6\u5b66\u7684\u6cbb\u7642\u306b\u3088\u308a\u816b\u760d\u91cf\u3092\u4e00\u6642\u7684\u306b\u6291\u3048\u3089\u308c\u3066\u3082\u3001\u751f\u304d\u6b8b\u3063\u305f\u6cbb\u7642\u8010\u6027\u304c\u3093\u7d30\u80de\u304c\u518d\u767a\u306e\u539f\u56e0\u3068\u306a\u308a\u3001\u6cbb\u7642\u6210\u7e3e\u5411\u4e0a\u306e\u5927\u304d\u306a\u969c\u58c1\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3092\u793a\u3059\u7d30\u80de\u96c6\u56e3\u306e\u540c\u5b9a\u3068\u5236\u5fa1\u306f\u3001\u304c\u3093\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u4e3b\u8981\u56e0\u3067\u3042\u308b\u518d\u767a\u306e\u514b\u670d\u306b\u3064\u306a\u304c\u308a\u3001\u591a\u304f\u306e\u60a3\u8005\u306e\u9577\u671f\u4e88\u5f8c\u6539\u5584\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u52a0\u3048\u3066\u3001\u518d\u767a\u6291\u5236\u306b\u3088\u308b\u533b\u7642\u8cbb\u306e\u524a\u6e1b\u3001\u9577\u671f\u5165\u9662\u3084\u6cbb\u7642\u306b\u3088\u308b\u52b4\u50cd\u751f\u7523\u6027\u306e\u4f4e\u4e0b\u9632\u6b62\u3001\u50cd\u304d\u76db\u308a\u4e16\u4ee3\u306e\u793e\u4f1a\u5fa9\u5e30\u306e\u4fc3\u9032\u306a\u3069\u3001\u793e\u4f1a\u7d4c\u6e08\u7684\u306a\u6ce2\u53ca\u52b9\u679c\u3082\u6975\u3081\u3066\u5927\u304d\u3044\u3068\u3044\u3048\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u518d\u767a\u306e\u8d77\u70b9\u3068\u306a\u308b\u5fae\u5c0f\u907a\u6b8b\u816b\u760d\u306f\u3001\u3054\u304f\u5c11\u6570\u306e\u7d30\u80de\u3067\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u73fe\u5728\u306e\u753b\u50cf\u8a3a\u65ad\u6280\u8853\u3084\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u3067\u306f\u305d\u306e\u5b58\u5728\u3092\u6349\u3048\u308b\u3053\u3068\u306f\u3082\u3068\u3088\u308a\u3001\u305d\u306e\u6027\u8cea\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u3082\u6975\u3081\u3066\u56f0\u96e3\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u3053\u306e\u8ab2\u984c\u306b\u5bfe\u3057\u3001\u81e8\u5e8a\u533b\u3068\u9023\u643a\u3057\u3066\u60a3\u8005\u816b\u760d\u304b\u3089\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u69cb\u7bc9\u3057\u3001\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u3084\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\u3068\u3044\u3063\u305f\u5148\u9032\u7684\u306a\u6280\u8853\u3092\u99c6\u4f7f\u3059\u308b\u3053\u3068\u3067\u3001\u518d\u767a\u3092\u5f15\u304d\u8d77\u3053\u3059\u672c\u8cea\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u5f97\u3089\u308c\u305f\u77e5\u898b\u306b\u57fa\u3065\u3044\u3066\u3001\u304c\u3093\u518d\u767a\u3092\u4e88\u9632\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u5275\u51fa\u3092\u76ee\u6307\u3057\u307e\u3059\u3002\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                <img decoding=\"async\" class=\"gazou-max\"\r\n                  src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Sato_Figure_PNG.png\"\r\n                  alt=\"Sato_Figure_PNG\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u53c2\u8003\u8ad6\u6587\r\n              <\/p>\r\n              <p>\r\n                1) Nakagawa S*, Sato T<sup>*#<\/sup> et al. Commun Biol. 8, 507. (2025) (<sup>*<\/sup>:equal contribution,\r\n                <sup>#<\/sup>: co-corresponding)<br>\r\n                2) Sase M<sup>*<\/sup>, Sato T<sup>*<\/sup> et al. Dev Cell. 60, 396-413.e6. (2025) (<sup>*<\/sup>:equal\r\n                contribution)<br>\r\n                3) Sato T et al. Nat Cell Biol. 22, 919-926. (2020)\r\n              <\/p>\r\n              <p>\r\n                <br>\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <h3 class=\"c-ttl\">2. \u91d1\u5c5e\u9175\u7d20\u306e\u69cb\u9020\u6a5f\u80fd\u89e3\u6790\u3068\u5927\u8178\u83cc\u30a2\u30df\u30ce\u9178\u8981\u6c42\u6027\u767a\u73fe\u5bbf\u4e3b\u682a\u958b\u767a<\/h3>\r\n              <p style=\"text-align: right;\">\r\n                <span class=\"color\"><strong>\uff08\u8b1b\u5e2b\u3000\u5ca9\u5d0e \u4fca\u96c4\uff09<\/strong><\/span>\r\n              <\/p>\r\n              <p>\r\n                \u7814\u7a76\u5185\u5bb9\u30fb\u696d\u7e3e\u7b49\u306e\u59d4\u7d30\u306b\u3064\u3044\u3066\u306f\u3001\u30ea\u30f3\u30af\u5148\u306e\u7814\u7a76\u30db\u30fc\u30e0\u30da\u30fc\u30b8<br>\r\n                <a href=\"http:\/\/fesworld.jp\/\" class=\"txtlink\" target=\"_blank\">https:\/\/fesworld.jp\/<\/a> \u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u53c2\u8003\u8ad6\u6587<br>\r\n                1) Iwasaki T et al. J. Am. Chem. Soc. 131, 13659-13667. (2009)<br>\r\n                2) Iwasaki T et al. J. Am. Chem. Soc. 134, 19731-19738. (2012)<br>\r\n                3) Iwasaki T et al. J. Biochem. (Review) 169, 387-394. (2021)\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <h3 class=\"c-ttl\">3. \u98df\u54c1\u56e0\u5b50\u304c\u95a2\u308f\u308b\u300c\u81ea\u7136\u514d\u75ab\u30b7\u30b0\u30ca\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u300d\u306e\u3057\u304f\u307f\u3092\u89e3\u304d<\/h3>\r\n              <p>\r\n                <span class=\"color\"><strong>\u660e\u304b\u3059 \uff5e\u611f\u67d3\u75c7\u30fb\u304c\u3093\u30fb\u708e\u75c7\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4f53\u306e\u9632\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63a2\u308b\uff5e<\/strong><\/span>\r\n              <\/p>\r\n              <p style=\"text-align: right;\">\r\n                <span class=\"color\"><strong><span style=\"font-size: 14pt;\">\uff08\u8b1b\u5e2b\u3000\u65e9\u5ddd \u6e05\u96c4\uff09<\/span><\/strong><\/span>\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u79c1\u305f\u3061\u306e\u4f53\u306b\u306f\u3001\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u3001\u304c\u3093\u7d30\u80de\u306a\u3069\u306e\u201c\u5916\u6575\u201d\u304b\u3089\u8eab\u3092\u5b88\u308b\u305f\u3081\u306e\u4ed5\u7d44\u307f\u304c\u5099\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001\u6700\u524d\u7dda\u3067\u50cd\u304f\u306e\u304c\u300c\u81ea\u7136\u514d\u75ab\uff08\u3057\u305c\u3093\u3081\u3093\u3048\u304d\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002<br>\r\n                \u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u98df\u54c1\u56e0\u5b50\u304c\u3001\u81ea\u7136\u514d\u75ab\u306e\u50cd\u304d\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3059\u308b\u306e\u304b\u3092\u3001\u7d30\u80de\u306e\u60c5\u5831\u4f1d\u9054\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08\uff1d\u30b7\u30b0\u30ca\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff09\u306b\u7740\u76ee\u3057\u3066\u3001\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002<br>\r\n                \u81ea\u7136\u514d\u75ab\u306f\u3001\u611f\u67d3\u75c7\u3001\u304c\u3093\u3001\u6162\u6027\u708e\u75c7\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u75c5\u6c17\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u3082\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u98df\u54c1\u56e0\u5b50\u304c\u81ea\u7136\u514d\u75ab\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u5c06\u6765\u7684\u306a\u75c5\u6c17\u306e\u4e88\u9632\u3084\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                <img decoding=\"async\" class=\"gazou-max\"\r\n                  src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Hayakawa_Figure_small.png\"\r\n                  alt=\"Hayakawa_Figure_small\" title=\"\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u53c2\u8003\u8ad6\u6587<br>\r\n                1) Hayakawa S et al. JCI Insight. 7, e138539. (2022)<br>\r\n                2) Hayakawa S*, Shiratori S* et al. Nat. Immunol. 12, 37-44. (2011) (*:equal contribution)<br>\r\n                3) Takaoka A, Hayakawa S et al. Nature. 424, 516-523. (2003)\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <h3 class=\"c-ttl\">4. \u54fa\u4e73\u985e\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20<\/h3>\r\n              <p>\r\n                <span class=\"color\">\u8131\u6c34\u7d20\u9175\u7d20 \/ \u9178\u5316\u9175\u7d20\u5909\u63db\u306e\u5206\u5b50\u6a5f\u69cb\u3068\u751f\u7406\u7684\u610f\u7fa9<\/strong><\/span>\r\n              <\/p>\r\n              <p style=\"text-align: right;\">\r\n                <span class=\"color\"><strong>\uff08\u52a9\u6559\u3000\u8349\u91ce \u8f1d\u7537\uff09<\/strong><\/span>\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20\uff08XOR\uff09\u306f\u5206\u5b50\u5185\u306b\u30e2\u30ea\u30d6\u30c9\u30d7\u30c6\u30ea\u30f3\u3001\u9244\u786b\u9ec4\u4e2d\u5fc3\u3001FAD\u3092\u542b\u3080\u91d1\u5c5e\u30d5\u30e9\u30d3\u30f3\u9175\u7d20\u3067\u3059\u3002\u751f\u4f53\u5185\u3067\u306f\u30d2\u30c8\u306e\u30d7\u30ea\u30f3\u4ee3\u8b1d\u306e\u6700\u7d42\u30b9\u30c6\u30c3\u30d7\u3092\u89e6\u5a92\u3059\u308b\u5c3f\u9178\u7523\u751f\u9175\u7d20\u3068\u3057\u3066\u50cd\u304d\u3001\u75db\u98a8\u6cbb\u7642\u85ac\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u751f\u4f53\u5185\u3067\u6d3b\u6027\u9178\u7d20\u3092\u7523\u751f\u3059\u308b\u5206\u5b50\u3068\u3057\u3066\u3001\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u591a\u304f\u306e\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u3001\u81e8\u5e8a\u533b\u5b66\u7684\u306b\u3082\u91cd\u8981\u3067\u3059<sup>1)<\/sup>\u3002\u54fa\u4e73\u985e\r\n                XOR \u306e\u7279\u5fb4\u3068\u3057\u3066\u6d3b\u6027\u5909\u63db\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002XOR\u306f\u901a\u5e38\u306f\u8131\u6c34\u7d20\u9175\u7d20\u6d3b\u6027\u3092\u793a\u3057\u3001\u5c3f\u9178\u751f\u6210\u306b\u3068\u3082\u306a\u3044 NADH\r\n                \u3092\u7523\u751f\u3057\u307e\u3059\u304c\u3001\u69cb\u9020\u5909\u5316\u3092\u304a\u3053\u3057\u9178\u5316\u9175\u7d20\u578b\u306b\u5909\u63db\u3055\u308c\u308b\u3068\u6d3b\u6027\u9178\u7d20\u3092\u7523\u751f\u3057\u307e\u3059\u3002\u3053\u306e\u6d3b\u6027\u5909\u63db\u306f\u3001\u5f93\u6765\u306f\u708e\u75c7\u3084\u969c\u5bb3\u3055\u308c\u305f\u7d44\u7e54\u306a\u3069\u306b\u8d77\u3053\u308b\u75c5\u7406\u7684\u306a\u73fe\u8c61\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u6700\u8fd1\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u4e73\u6c41\u3084\u53e3\u8154\u7c98\u819c\u3067\u306f\u4ed6\u306e\u5206\u5b50\u3068\u5354\u8abf\u3057\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5c40\u6240\u514d\u75ab\u306e\u4e00\u74b0\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f3\uff09<sup>2)<\/sup>\u3002\u3053\u306e\u81ea\u7136\u514d\u75ab\u6a5f\u69cb\u306f\r\n                XOR \u306e\u6d3b\u6027\u5909\u63db\u3092\u30c8\u30ea\u30ac\u30fc\u3068\u3057\u3066\u304a\u308a\u3001\u75db\u98a8\u6cbb\u7642\u85ac\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u3066\u3044\u308b XOR \u963b\u5bb3\u5264\u3067\u6297\u83cc\u4f5c\u7528\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u305f\u3081\u3001\u73fe\u5728\u306f\u81e8\u5e8a\u5fdc\u7528\u306b\u3064\u306a\u3052\u308b\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\r\n              <\/p>\r\n              <p>\r\n                <br>\r\n              <\/p>\r\n              <p>\r\n                <img decoding=\"async\" class=\"gazou-max\"\r\n                  src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Kusano_Figure_small.png\"\r\n                  alt=\"Kusano_Figure_small\" title=\"\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u53c2\u8003\u6587\u732e<br>\r\n                1) Kusano T et al. Redox Biol. 59, 102573.(2023)<br>\r\n                2) Kusano T et al. Nat Commun. 10, 4904. (2019)\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <h3 class=\"c-ttl\">5.&nbsp;\u30cd\u30aa\u30fb\u30bb\u30eb\u30d5\u6297\u4f53\u7523\u751f\u306b\u3088\u308b\u81ea\u5df1\u6297\u4f53\u306e\u63a2\u7d22\u3068\u3001\u9838\u7ba1\u719f\u5316\u6a5f\u69cb\u306e\u89e3\u660e<\/h3>\r\n              <p style=\"text-align: right;\">\r\n                <span class=\"color\"><strong>\uff08\u52a9\u6559\u3000\u7247\u5c71 \u6620\uff09<\/strong><\/span>\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u30fb\u6d41\u7523\u30fb\u6b7b\u7523\u3092\u53cd\u5fa9\u3059\u308b\u4e0d\u80b2\u75c7\u60a3\u8005\u306e\u3046\u3061\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u75c7\u72b6\u3092\u793a\u3059\u304c\u3001\u75c5\u56e0\u304c\u4e0d\u660e\u306a\u60a3\u8005\u304c\u5b58\u5728\u3059\u308b\u3002\u975e\u514d\u75ab\u7d30\u80de\u7531\u6765\u306e\u30cd\u30aa\u30fb\u30bb\u30eb\u30d5\u6297\u539f\uff0d\u6297\u4f53\u306f\u3001\u53e4\u5178\u7684\u306a\u9069\u5fdc\u514d\u75ab\u306e\u958b\u59cb\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u306f\u7570\u306a\u308b\u7523\u751f\u6a5f\u69cb\u3067\u767a\u73fe\u3057\u3001\u305d\u306e\u4e00\u90e8\u306f\u4e0d\u80b2\u75c7\u306e\u75c5\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u3001\u672a\u77e5\u306e\u81ea\u5df1\u6297\u539f\u306e\u63a2\u7d22\u3068\u3057\u3066\u3001iPS\u7d30\u80de\u3084\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u306b\u3088\u308b\u30cd\u30aa\u30fb\u30bb\u30eb\u30d5\u6297\u4f53\u7523\u751f\u6a5f\u69cb\u306b\u57fa\u3065\u3044\u305f\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u308b(\u56f31)\u3002\u73fe\u5728\u3001\u708e\u75c7\u523a\u6fc0\u306b\u3088\u308a\u3001\u7d30\u80de\u8868\u9762\u306b\u63d0\u793a\u308c\u305fMHC\u30af\u30e9\u30b92\u8907\u5408\u4f53\u306b\u542b\u307e\u308c\u308b\u6297\u539f\u5019\u88dc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u540c\u5b9a\u6cd5\u3092\u78ba\u7acb\u3057\u3001\u3055\u3089\u306b\u60a3\u8005\u691c\u4f53\u3078\u306e\u9069\u5fdc\u3092\u9032\u3081\u3066\u3044\u308b\u3002\r\n              <\/p>\r\n              <p>\r\n                \u30fb\u598a\u5a20\u4e2d\u671f\u3088\u308a\u9838\u7ba1\u719f\u5316\u304c\u9032\u307f\u65e9\u7523\u3068\u306a\u308b\u75c5\u614b\u306f\u3001\u598a\u5a20\u306e\u7dad\u6301\u306b\u95a2\u308f\u308b\u30db\u30eb\u30e2\u30f3\u306e\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3(P4)\u306e\u611f\u53d7\u6027\u304c\u8981\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u308b\u3002\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u9838\u7ba1\u3092\u69cb\u6210\u3059\u308b\u4e3b\u8981\u306a\u7d30\u80de\u3067\u3001P4\u53d7\u5bb9\u4f53\u306b\u3088\u308b\u8ee2\u5199\u8abf\u7bc0\u6a5f\u69cb\u306b\u3088\u308a\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30af\u30b9\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3002\u65e9\u7523\u6642\u306e\u9838\u7ba1\u719f\u5316\u306e\u5206\u5b50\u6a5f\u69cb\u306b\u3064\u3044\u3066\u3001\u60a3\u8005\u691c\u4f53\u7531\u6765\u306e\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u305f\u89e3\u660e\u3092\u884c\u3063\u3066\u3044\u308b\u3002\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                <img decoding=\"async\" class=\"gazou-max\"\r\n                  src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Katayama_Figure.jpg\"\r\n                  alt=\"Katayama_Figure\" title=\"\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u53c2\u8003\u6587\u732e<br>\r\n                1) Kuwabara Y, Katayama A, et al. PLOS one. 13, e0198472. (2018)<br>\r\n                2) Kuwabara Y, Katayama A, et al. Am J Reprod Immunol. 78 (2017)\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <h3 class=\"c-ttl\">6.&nbsp;\u907a\u4f1d\u6027\u75be\u60a3\u306b\u95a2\u308f\u308b\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u3092\u3082\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020<span style=\"font-size: 12pt;\">\u30fb<\/span>\u6a5f\u80fd\u89e3\u6790<\/h3>\r\n              <\/p>\r\n              <p style=\"text-align: right;\">\r\n                <span class=\"color\"><strong>\uff08\u52a9\u6559\u3000\u677e\u6751 \u667a\u88d5\uff09<\/strong><\/span>\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7acb\u4f53\u69cb\u9020\u304c\u6b63\u3057\u304f\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3067\u7279\u5b9a\u306e\u6a5f\u80fd\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9ad8\u6b21\u69cb\u9020\uff08\u4e09\u6b21\u3001\u56db\u6b21\u69cb\u9020\uff09\u3092\u69cb\u6210\u3059\u308b\u91cd\u8981\u306a\u5316\u5b66\u7d50\u5408\u306b\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\uff08S-S\r\n                \u7d50\u5408\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u5206\u5b50\u5185\uff08\u4e09\u6b21\u69cb\u9020\uff09\u3042\u308b\u3044\u306f\u5206\u5b50\u9593\uff08\u56db\u6b21\u69cb\u9020\uff09\u306eS-S \u7d50\u5408\u304c\u53ef\u9006\u7684\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u3067\u6a5f\u80fd\u304c\u5909\u5316\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7740\u76ee\u3057\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<br>\r\n                \u7814\u7a76\u3092\u59cb\u3081\u308b\u304d\u3063\u304b\u3051\u3068\u306a\u3063\u305fXanthine Oxidoreductase (XOR)\u306f\u3001\u5206\u5b50\u5185S-S\r\n                \u7d50\u5408\u306e\u6709\u7121\u3067\u9178\u5316\u9175\u7d20\u304b\u3089\u8131\u6c34\u7d20\u9175\u7d20\u3078\u3068\u53ef\u9006\u7684\u306b\u5909\u63db\u3055\u308c\u308b\u3053\u3068\u304c\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305fPeroxiredoxin I (Prx\r\n                I)\u306f\u3001\u4e8c\u91cf\u4f53\u3068\u5341\u91cf\u4f53\u306e2\u3064\u306e\u69cb\u9020\u306b\u3088\u3063\u3066\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u6d3b\u6027\u304c\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u3001\u5206\u5b50\u9593\u306eS-S\r\n                \u7d50\u5408\u306b\u95a2\u308f\u308bCys\u6b8b\u57fa\u306e\u5909\u7570\u4f53\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306b\u3064\u3044\u3066\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306eX\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u306b\u3082\u6210\u529f\u3057\u3066\u3044\u307e\u3059(1,\r\n                2)\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u6027\u75be\u60a3\u306b\u95a2\u308f\u308b\u30a2\u30eb\u30ab\u30ea\u30d5\u30a9\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\uff08ALP\uff09\u3068\u30b3\u30af\u30ea\u30f3\uff08Cochlin\uff09\u306b\u7740\u76ee\u3057\u3066\u69cb\u9020\u30fb\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7d44\u7e54\u975e\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308bALP\u306f\u5206\u5b50\u5185S-S\r\n                \u7d50\u5408\u304c1\u30ab\u6240\u5b58\u5728\u3057\u3001\u3053\u306eCys\u6b8b\u57fa\u304c\u5909\u7570\u3059\u308b\u3068\u6d3b\u6027\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u3066\u4f4e\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u75c7\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30b3\u30af\u30ea\u30f3\u306f\u5185\u8033\u306b\u7279\u306b\u591a\u304f\u767a\u73fe\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u907a\u4f1d\u6027\u96e3\u8074DFNA9\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002N-\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u304c\u5207\u65ad\u3055\u308c\u305fCochlin\r\n                tomo-protein\r\n                (CTP)\u306f\u5185\u8033\u306e\u5916\u30ea\u30f3\u30d1\u306b\u7279\u306b\u591a\u304f\u5206\u6ccc\u3055\u308c\u3066\u3044\u307e\u3059(3)\u3002CTP\u306f\u5916\u30ea\u30f3\u30d1\u763b\u75be\u60a3\u3092\u9451\u5225\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f53\u5916\u8a3a\u65ad\u85ac\u304c\u958b\u767a\u3055\u308c2022\u5e74\u306b\u4fdd\u967a\u53ce\u8f09\u3055\u308c\u307e\u3057\u305f\u3002CTP\u306b\u306f\u4fdd\u5b58\u6027\u306e\u9ad8\u30444\u3064\u306eCys\u6b8b\u57fa\u304c\u5b58\u5728\u3057\u3001\u5206\u5b50\u5185\u30672\u7d44\u306eS-S\r\n                \u7d50\u5408\u304c\u5f62\u6210\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u308c\u3089ALP\u3084CTP\u306b\u3064\u3044\u3066\u3001\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305fin\r\n                vitro\u30ea\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u624b\u6cd5\u3092\u4e00\u3064\u306e\u8db3\u304c\u304b\u308a\u3068\u3057\u3066\u3001S-S \u7d50\u5408\u304c\u6301\u3064\u91cd\u8981\u306a\u6a5f\u80fd\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\r\n              <\/p>\r\n              <p>\r\n                <br>\r\n              <\/p>\r\n              <p>\r\n                <img decoding=\"async\" class=\"gazou-max\"\r\n                  src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Matsumura_Figure.png\"\r\n                  alt=\"Matsumura_Figure\" title=\"\">\r\n              <\/p>\r\n              <p>\r\n                <br data-br=\"1\">\r\n              <\/p>\r\n              <p>\r\n                \u53c2\u8003\u6587\u732e\r\n              <\/p>\r\n              <p>\r\n                1) Yamaguchi Y, Matsumura T, et al. J. Biochem. 141, 513-24. (2007).<br>\r\n                2) Matsumura T, et al. J. Biol. Chem. 283, 284-93. (2008).<br>\r\n                3) Ikezono T, Matsumura T, et al. PLoS One. 13, e0191498. (2018)\r\n              <\/p>\r\n            <\/div>\r\n          <\/div>\r\n        <\/li>\r\n        <li class=\"accordion\">\r\n          <div class=\"acc-header\">\u4e3b\u306a\u767a\u8868\u8ad6\u6587<\/div>\r\n          <div class=\"acc-content\">\r\n            <div>\r\n              <div class=\"sec_base\">\r\n                <div>\r\n                  <h3 class=\"c-ttl\">\u5927\u5b66\u9662\u6559\u6388\u3000\u4f50\u85e4 \u5353<\/h3>\r\n                  <p>\r\n                    <span style=\"color: #000000;\">1. <strong><span style=\"text-decoration: underline;\">Sato\r\n                          T<\/span><\/strong>. Role of Patient-Derived Tumor Organoids in Advanced Cancer Research. J\r\n                      Nippon Med Sch. 2025;92(3):234-241. doi: 10.1272\/jnms.JNMS.2025_92-310. (Review)<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br data-br=\"1\">\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\">2. Nakagawa S*,\r\n                        <strong><span style=\"text-decoration: underline;\">Sato T<sup>*<\/sup><\/span><\/strong>, Ohashi E*,\r\n                        Kajita M*, Miya F, Yamamoto K, Yotsumata H, Yamaguchi K, Nakajima Y, Miura A, Kinugasa Y, Ohteki\r\n                        T. An organoid library of human esophageal squamous cell carcinomas (ESCCs) uncovers the\r\n                        chemotherapy-resistant ESCC features. <em><strong>Commun Biol.<\/strong><\/em> 2025 Apr\r\n                        1;8(1):507. doi: 10.1038\/s42003-025-07869-4. (*: equal contribution, #: Co-corresponding\r\n                        author)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        3. Sase M*, <span style=\"text-decoration: underline;\"><strong>Sato\r\n                            T<sup>*<\/sup><\/strong><\/span>, Sato H, Miya F, Zhang S, Haeno H, Kajita M, Noguchi T, Mori\r\n                        Y, Ohteki T. Comparative analysis of tongue cancer organoids among patients identifies the\r\n                        heritable nature of minimal residual disease. <em><strong>Dev Cell.<\/strong><\/em> 2025 Feb\r\n                        3;60(3):396-413.e6. doi: 10.1016\/j.devcel.2024.10.007. (*: equal contribution)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        4. Kanayama M, Izumi Y, Akiyama M, Hayashi T, Atarashi K, Roers A, <span\r\n                          style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ohteki T. Myeloid-like B\r\n                        cells boost emergency myelopoiesis through IL-10 production during infection. <em><strong>J Exp\r\n                            Med<\/strong><strong>.<\/strong><\/em> 2023 Apr 3;220(4):e20221221. doi:\r\n                        10.1084\/jem.20221221.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        5. Minamide K*, <span style=\"text-decoration: underline;\"><strong>Sato\r\n                            T<sup>*<\/sup><\/strong><\/span>, Nakanishi Y, Ohno H, Kato T, Asano J, Ohteki T. IRF2\r\n                        maintains the stemness of colonic stem cells by limiting physiological stress from interferon.\r\n                        <em><strong>Sci Rep.<\/strong><\/em> 2020 Sep 8;10(1):14639. doi: 10.1038\/s41598-020-71633-3. (*:\r\n                        equal contribution)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        6. <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ishikawa S, Asano\r\n                        J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T. Regulated\r\n                        IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation\r\n                        into secretory-cell lineages. <em><strong>Nat Cell Biol.<\/strong><\/em> 2020 Aug;22(8):919-926.\r\n                        doi: 10.1038\/s41556-020-0545-5.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        7. <span style=\"text-decoration: underline;\"><strong>Sato T<sup>*<\/sup><\/strong><\/span>, Sase\r\n                        M*, Ishikawa S, Kajita M, Asano J, Sato T, Mori Y, Ohteki T. Characterization of radioresistant\r\n                        epithelial stem cell heterogeneity in the damaged mouse intestine. <em><strong>Sci\r\n                            Rep.<\/strong><\/em> 2020 May 22;10(1):8308. doi: 10.1038\/s41598-020-64987-1. (*: equal\r\n                        contribution)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        8. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, <span\r\n                          style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Kajita M, Ohteki T.\r\n                        CD86-based analysis enables observation of bona fide hematopoietic responses.\r\n                        <em><strong>Blood.<\/strong><\/em> 2020 Sep 3;136(10):1144-1154. doi:\r\n                        10.1182\/blood.2020004923.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        9. Nakanishi Y, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>,\r\n                        Takahashi K, Ohteki T. IFN-\u03b3-dependent epigenetic regulation instructs colitogenic\r\n                        monocyte\/macrophage lineage differentiation in vivo. <em><strong>Mucosal Immunol.<\/strong><\/em>\r\n                        2018 May;11(3):871-880. doi: 10.1038\/mi.2017.104.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        10. Kawamura S, Onai N, Miya F, <span style=\"text-decoration: underline;\"><strong>Sato\r\n                            T<\/strong><\/span>, Tsunoda T, Kurabayashi K, Yotsumoto S, Kuroda S, Takenaka K, Akashi K,\r\n                        Ohteki T. Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation\r\n                        Potential: A Counterpart of Mouse cMoPs. <em><strong>Immunity.<\/strong><\/em> 2017 May\r\n                        16;46(5):835-848.e4. doi: 10.1016\/j.immuni.2017.04.019.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        11. Asano J, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ichinose\r\n                        S, Kajita M, Onai N, Shimizu S, Ohteki T. Intrinsic Autophagy Is Required for the Maintenance of\r\n                        Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. <em><strong>Cell\r\n                            Rep.<\/strong><\/em> 2017 Aug 1;20(5):1050-1060. doi:\r\n                        10.1016\/j.celrep.2017.07.019.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        12. Yokoi T, Yokoi K, Akiyama K, Higuchi T, Shimada Y, Kobayashi H, <span\r\n                          style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ohteki T, Otsu M, Nakauchi\r\n                        H, Ida H, Ohashi T. Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is\r\n                        efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II.\r\n                        <em><strong>Mol Genet Metab.<\/strong><\/em> 2016 Nov;119(3):232-238. doi:\r\n                        10.1016\/j.ymgme.2016.08.003.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        13. Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, <span\r\n                          style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ohteki T, Hayakawa Y,\r\n                        Barber GN, Kurokawa M, Suda T, Takubo K. Bacterial c-di-GMP affects hematopoietic\r\n                        stem\/progenitors and their niches through STING. <em><strong>Cell Rep.<\/strong><\/em> 2015 Apr\r\n                        7;11(1):71-84. doi: 10.1016\/j.celrep.2015.02.066.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        14. Nakanishi Y, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>,\r\n                        Ohteki T. Commensal Gram-positive bacteria initiates colitis by inducing monocyte\/macrophage\r\n                        mobilization. <em><strong>Mucosal Immunol.<\/strong><\/em> 2015 Jan;8(1):152-60. doi:\r\n                        10.1038\/mi.2014.53.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        15. <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ikeda M, Yotsumoto\r\n                        S, Shimada Y, Higuchi T, Kobayashi H, Fukuda T, Ohashi T, Suda T, Ohteki T. Novel\r\n                        interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic\r\n                        disorder. <em><strong>Blood.<\/strong><\/em> 2013 Apr 18;121(16):3267-73. doi:\r\n                        10.1182\/blood-2012-07-443713.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        16. Ohyagi H, Onai N, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>,\r\n                        Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, M\u00fcller W, Kurabayashi K,\r\n                        Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, Ohteki T. Monocyte-derived\r\n                        dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.\r\n                        <em><strong>Immunity.<\/strong><\/em> 2013 Sep 19;39(3):584-98. doi:\r\n                        10.1016\/j.immuni.2013.06.019.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        17. Mashima H, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Horie\r\n                        Y, Nakagawa Y, Kojima I, Ohteki T, Ohnishi H. Interferon regulatory factor-2 regulates\r\n                        exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.\r\n                        <em><strong>Gastroenterology.<\/strong><\/em> 2011 Sep;141(3):1102-1113.e1-8. doi:\r\n                        10.1053\/j.gastro.2011.05.051.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        18. Tezuka H, Abe Y, Asano J, <span style=\"text-decoration: underline;\"><strong>Sato\r\n                            T<\/strong><\/span>, Liu J, Iwata M, Ohteki T. Prominent role for plasmacytoid dendritic cells\r\n                        in mucosal T cell-independent IgA induction. <em><strong>Immunity.<\/strong><\/em> 2011 Feb\r\n                        25;34(2):247-57. doi: 10.1016\/j.immuni.2011.02.002.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        19. Asano J, Tada H, Onai N, <span style=\"text-decoration: underline;\"><strong>Sato\r\n                            T<\/strong><\/span>, Horie Y, Fujimoto Y, Fukase K, Suzuki A, Mak TW, Ohteki T. Nucleotide\r\n                        oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated\r\n                        cross-priming in vivo. <em><strong>J Immunol.<\/strong><\/em> 2010 Jan 15;184(2):736-45. doi:\r\n                        10.4049\/jimmunol.0900726. Epub 2009 Dec 11.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        20. <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Onai N, Yoshihara\r\n                        H, Arai F, Suda T, Ohteki T. Interferon regulatory factor-2 protects quiescent hematopoietic\r\n                        stem cells from type I interferon-dependent exhaustion. <em><strong>Nat Med.<\/strong><\/em> 2009\r\n                        Jun;15(6):696-700. doi: 10.1038\/nm.1973.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                  <\/p>\r\n                  <p>\r\n                    <br data-br=\"1\">\r\n                  <\/p>\r\n                  <h3 class=\"c-ttl\">\u8b1b\u5e2b\u3000\u5ca9\u5d0e \u4fca\u96c4<\/h3>\r\n                  <p>\r\n                    <span style=\"color: #000000;\">1. Boos JR,&nbsp;Jandrain HN, Hagiuda E, Taguchi AT, Hasegawa K, Fedun\r\n                      BL, Taylor SJ, Elad SM, Faber SE, Kumasaka T, <span\r\n                        style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Geldenhuys WJ. Structure\r\n                      and biological evaluation of Caenorhabditis elegansCISD-1\/mitoNEET, a KLP-17 tail domain\r\n                      homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated\r\n                      antioxidant defense response. <em><strong>Adv Redox Res.<\/strong><\/em> 2022 Dec;6:100048. doi:\r\n                      10.1016\/j.arres.2022.100048. (Co-corresponding author)<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br data-br=\"1\"><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\">2. <span\r\n                          style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,&nbsp;Miyajima-Nakano Y,\r\n                        Fukazawa R, Lin MT, Matsushita SI, Hagiuda E, Taguchi AT, Dikanov SA, Oishi Y, Gennis RB.\r\n                        Escherichia coli amino acid auxotrophic expression host strains for investigating protein\r\n                        structure-function relationships. <em><strong>J Biochem.<\/strong><\/em> 2021 Apr\r\n                        29;169(4):387-394. doi: 10.1093\/jb\/mvaa140. (Corresponding author)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        3. Geldenhuys WJ,&nbsp;Long TE, Saralkar P, <span\r\n                          style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Nu\u00f1ez RAA, Nair RR,\r\n                        Konkle ME, Menze MA, Pinti MV, Hollander JM, Hazlehurst LA, Robart AR. Crystal structure of the\r\n                        mitochondrial protein mitoNEET bound to a benze-sulfonide ligand. <em><strong>Commun\r\n                            Chem.<\/strong><\/em> 2019;2:77. doi: 10.1038\/s42004-019-0172-x.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        4. Taguchi AT,&nbsp;Ohmori D, Dikanov SA, <span\r\n                          style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>. g-Tensor Directions in\r\n                        the Protein Structural Frame of Hyperthermophilic Archaeal Reduced Rieske-Type Ferredoxin\r\n                        Explored by 13C Pulsed Electron Paramagnetic Resonance. <em><strong>Biochemistry.<\/strong><\/em>\r\n                        2018 Jul 17;57(28):4074-4082. doi: 10.1021\/acs.biochem.8b00438. (Co-corresponding\r\n                        author)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        5. Taguchi AT, Miyajima-Nakano Y, Fukazawa R, Lin MT, Baldansuren A, Gennis RB, Hasegawa K,\r\n                        Kumasaka T, Dikanov SA,<\/span><\/span> <span color=\"#000000\"><span\r\n                        style=\"font-size: 13.3333px;\"><span style=\"text-decoration: underline;\"><strong>Iwasaki\r\n                            T<\/strong><\/span>.<\/span><\/span>&nbsp;<span style=\"color: #000000;\">Unpaired Electron Spin\r\n                      Density Distribution across Reduced [2Fe-2S] Cluster Ligands by 13Cb-Cysteine Labeling.\r\n                      <strong><em>Inorg Chem.<\/em><\/strong> 2018 Jan 16;57(2):741-746. doi:\r\n                      10.1021\/acs.inorgchem.7b02676. (Co-corresponding author)<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        6. Lin MT, Fukazawa R, Miyajima-Nakano Y, Matsushita S, Choi SK, <span\r\n                          style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,&nbsp;Gennis RB.\r\n                        Escherichia coli auxotroph host strains for amino acid-selective isotope labeling of recombinant\r\n                        proteins. <em><strong>Methods Enzymol.<\/strong><\/em> 2015;565:45-66. doi:\r\n                        10.1016\/bs.mie.2015.05.012. (Co-corresponding author)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        7. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Fukazawa R,\r\n                        Miyajima-Nakano Y, Baldansuren A, Matsushita S, Lin MT, Gennis RB, Hasegawa K, Kumasaka T,\r\n                        Dikanov SA. Dissection of hydrogen bond interaction network around an iron-sulfur cluster by\r\n                        site-specific isotope labeling of hyperthermophilic archaeal Rieske-type ferredoxin.\r\n                        <em><strong>J Am Chem Soc.<\/strong><\/em> 2012 Dec 5;134(48):19731-8. doi: 10.1021\/ja308049u.\r\n                        (Co-corresponding author)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        8. Lin MT, Sperling LJ, Frericks Schmidt HL, Tang M, Samoilova RI, Kumasaka T, <span\r\n                          style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,&nbsp;Dikanov SA,\r\n                        Rienstra CM, Gennis RB. A rapid and robust method for selective isotope labeling of proteins.\r\n                        <em><strong>Methods.<\/strong><\/em> 2011 Dec;55(4):370-8. doi:\r\n                        10.1016\/j.ymeth.2011.08.019.<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        9. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,&nbsp;Kappl R,\r\n                        Bracic G, Shimizu N, Ohmori D, Kumasaka T. ISC-like [2Fe-2S] ferredoxin (FdxB) dimer from\r\n                        Pseudomonas putida JCM 20004: structural and electron-nuclear double resonance characterization.\r\n                        <em><strong>J Biol Inorg Chem.<\/strong><\/em> 2011 Aug;16(6):923-35. doi:\r\n                        10.1007\/s00775-011-0793-8. (Co-corresponding author)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        10. <span style=\"text-decoration: underline;\"><strong>Iwasaki\r\n                            T<\/strong><\/span>.&nbsp;Iron-sulfur world in aerobic and hyperthermoacidophilic archaea\r\n                        Sulfolobus. <em><strong>Archaea.<\/strong><\/em> 2010 Sep 19;2010:842639. doi:\r\n                        10.1155\/2010\/842639. (Corresponding author)<\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        11. Kounosu A, Hasegawa K, <span style=\"text-decoration: underline;\"><strong>Iwasaki\r\n                            T<\/strong><\/span>, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of\r\n                        hyperthermophilic archaeal Rieske-type ferredoxin (ARF) from Sulfolobus solfataricus P1.\r\n                        <em><strong>Acta Crystallogr Sect F Struct Biol Cryst Commun<\/strong><\/em>. 2010 Jul 1;66(Pt\r\n                        7):842-5. doi: 10.1107\/S1744309110019263. Epub 2010 Jun 24. PMID: 20606288; PMCID:\r\n                        PMC2898476.<span>(Co-corresponding author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        12. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Samoilova RI,\r\n                        Kounosu A, Ohmori D, Dikanov SA. Continuous-wave and pulsed EPR characterization of the\r\n                        [2Fe-2S](Cys)3(His)1 cluster in rat MitoNEET. <em><strong>J Am Chem Soc.<\/strong><\/em> 2009 Sep\r\n                        30;131(38):13659-67. doi: 10.1021\/ja903228w. PMID: 19736979; PMCID:\r\n                        PMC2756718.<span>(Co-corresponding author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        13. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Samoilova RI,\r\n                        Kounosu A, Dikanov SA. Two-dimensional pulsed electron spin resonance characterization of\r\n                        15N-labeled archaeal Rieske-type ferredoxin. <em><strong>FEBS Lett.<\/strong><\/em> 2009 Nov\r\n                        3;583(21):3467-72. doi: 10.1016\/j.febslet.2009.09.050. Epub 2009 Oct 3. PMID: 19804777; PMCID:\r\n                        PMC2783746.<span>(Co-corresponding author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        14. Kounosu A, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Baba\r\n                        S, Hayashi-Iwasaki Y, Oshima T, Kumasaka T. Crystallization and preliminary X-ray diffraction\r\n                        studies of the prototypal homologue of mitoNEET (Tth-NEET0026) from the extreme thermophile\r\n                        Thermus thermophilus HB8. <em><strong>Acta Crystallogr Sect F Struct Biol Cryst\r\n                            Commun<\/strong><\/em>. 2008 Dec 1;64(Pt 12):1146-8. doi: 10.1107\/S1744309108035975. Epub 2008\r\n                        Nov 28. PMID: 19052371; PMCID: PMC2593688.<span>(Co-corresponding author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        15. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Ohmori D,\r\n                        Shimizu N, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of the ISC-like\r\n                        [2Fe-2S] ferredoxin (FdxB) from Pseudomonas putida JCM 20004. <em><strong>Acta Crystallogr Sect\r\n                            F Struct Biol Cryst Commun.<\/strong><\/em> 2007 Dec 1;63(Pt 12):1014-6. doi:\r\n                        10.1107\/S1744309107045757. Epub 2007 Nov 21. PMID: 18084081; PMCID:\r\n                        PMC2344098.<span>(Co-corresponding author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        16. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A,\r\n                        Ohmori D, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of a\r\n                        hyperthermophilic Rieske protein variant (SDX-triple) with an engineered rubredoxin-like\r\n                        mononuclear iron site. A<em><strong>cta Crystallogr Sect F Struct Biol Cryst\r\n                            Commun<\/strong><\/em>. 2006 Oct 1;62(Pt 10):993-5. doi: 10.1107\/S1744309106034476. Epub 2006\r\n                        Sep 30. PMID: 17012793; PMCID: PMC2225183.<span>(Co-corresponding author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        17. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A,\r\n                        Kolling DR, Lhee S, Crofts AR, Dikanov SA, Uchiyama T, Kumasaka T, Ishikawa H, Kono M, Imai T,\r\n                        Urushiyama A. Resonance Raman characterization of archaeal and bacterial Rieske protein variants\r\n                        with modified hydrogen bond network around the [2Fe-2S] center. <em><strong>Protein\r\n                            Sci<\/strong><\/em>. 2006 Aug;15(8):2019-24. doi: 10.1110\/ps.052035406. PMID: 16877714; PMCID:\r\n                        PMC2242589.<span>(Co-corresponding author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        18. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A,\r\n                        Samoilova RI, Dikanov SA. 15N HYSCORE characterization of the fully deprotonated, reduced form\r\n                        of the archaeal Rieske [2Fe-2S] center. <em><strong>J Am Chem Soc<\/strong><\/em>. 2006 Feb\r\n                        22;128(7):2170-1. doi: 10.1021\/ja0562393. PMID: 16478144.<span>(Co-corresponding\r\n                          author)<\/span><\/span><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br>\r\n                        19. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A, Tao\r\n                        Y, Li Z, Shokes JE, Cosper NJ, Imai T, Urushiyama A, Scott RA. Rational design of a mononuclear\r\n                        metal site into the archaeal Rieske-type protein scaffold. <em><strong>J Biol\r\n                            Chem<\/strong><\/em>. 2005 Mar 11;280(10):9129-34. doi: 10.1074\/jbc.M414051200. Epub 2005 Jan\r\n                        4. 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CD206+ macrophages facilitate wound healing through interactions with Gpnmbhi\r\n                      fibroblasts. <em><strong>EMBO Rep<\/strong><\/em>. 2025 Jun 10. doi:\r\n                      10.1038\/s44319-025-00496-4.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">2. Narai-Kanayama A*, <span\r\n                        style=\"text-decoration: underline;\"><strong>Hayakawa S<sup>*<\/sup><\/strong><\/span>, Yoshino T,\r\n                      Honda F, Matsuda H, Oishi Y. Differential effects of theasinensins and\r\n                      epigallocatechin-3-O-gallate on phospholipid bilayer structure and liposomal aggregation.\r\n                      <em><strong>Biochim Biophys Acta Biomembr<\/strong><\/em>. 2024 Jun;1866(5):184312. doi:\r\n                      10.1016\/j.bbamem.2024.184312. 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Yamaguchi F*, <span\r\n                        style=\"text-decoration: underline;\"><strong>Hayakawa S<sup>*<\/sup><\/strong><\/span>, Kawashima S,\r\n                      Asakura T, Oishi Y. Antitumor effect of memantine is related to the formation of the splicing\r\n                      isoform of GLG1, a decoy FGF binding protein. <em><strong>Int J Oncol<\/strong><\/em>. 2022\r\n                      Jul;61(1):80. doi: 10.3892\/ijo.2022.5370. (*: equal contribution)<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">9. Ohishi T, <span\r\n                        style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Miyoshi N. Involvement\r\n                      of microRNA modifications in anticancer effects of major polyphenols from green tea, coffee, wine,\r\n                      and curry. <em><strong>Crit Rev Food Sci Nutr<\/strong><\/em>. 2023;63(24):7148-7179. doi:\r\n                      10.1080\/10408398.2022.2038540.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">10. <span style=\"text-decoration: underline;\"><strong>Hayakawa\r\n                          S<\/strong><\/span>, Ohishi T, Miyoshi N, Oishi Y, Nakamura Y, Isemura M. Anti-Cancer Effects of\r\n                      Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid.\r\n                      <em><strong>Molecules<\/strong><\/em>. 2020 Oct 5;25(19):4553. doi: 10.3390\/molecules25194553. 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Kawata K, Iwai A, Muramatsu D, Aoki S, Uchiyama H, Okabe M, <span\r\n                        style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Takaoka A, Miyazaki T.\r\n                      Stimulation of macrophages with the \u03b2-glucan produced by aureobasidium pullulans promotes the\r\n                      secretion of tumor necrosis factor-related apoptosis inducing ligand (TRAIL).\r\n                      <em><strong>PLoS<\/strong> <strong>One<\/strong><\/em>. 2015 Apr 13;10(4):e0124809. doi:\r\n                      10.1371\/journal.pone.0124809.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">15. Tabuchi M*, <span\r\n                        style=\"text-decoration: underline;\"><strong>Hayakawa S<sup>*<\/sup><\/strong><\/span>, Honda E,\r\n                      Ooshima K, Itoh T, Yoshida K, Park AM, Higashino H, Isemura M, Munakata H.\r\n                      Epigallocatechin-3-gallate suppresses transforming growth factor-beta signaling by interacting\r\n                      with the transforming growth factor-beta type II receptor. <em><strong>World J Exp\r\n                          Med<\/strong><\/em> 2013; 3(4): 100-107 doi: 10.5493\/wjem.v3.i4.100. (*: equal\r\n                      contribution)<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">16. Park AM, <span\r\n                        style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Honda E, Mine Y, Yoshida\r\n                      K, Munakata H. 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Isogai N, Nakagawa Y, Suzuki K, Yamada R, Asamura S, <span\r\n                        style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Munakata H.\r\n                      Cytokine-rich autologous serum system for cartilaginous tissue engineering. <em><strong>Ann Plast\r\n                          Surg<\/strong><\/em>. 2008 Jun;60(6):703-9. doi: 10.1097\/SAP.0b013e31814b2cb5.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">20. Hagiwara S, Kudo M, Nakatani T, Sakaguchi Y, Nagashima M, Fukuta\r\n                      N, Kimura M, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>,\r\n                      Munakata H. Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in\r\n                      nude mice by apoptosis of p53. <em><strong>Br J Cancer<\/strong>.<\/em> 2007 Dec 3;97(11):1532-7.\r\n                      doi: 10.1038\/sj.bjc.6604058. Epub 2007 Oct 30.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                  <\/p>\r\n                  <h3 class=\"c-ttl\">\u52a9\u6559\u3000\u8349\u91ce \u8f1d\u7537<\/h3>\r\n\r\n                  <p>\r\n                    <span style=\"color: #000000;\">1. Sato N, <span style=\"text-decoration: underline;\"><strong>Kusano\r\n                          T<\/strong><\/span>, Nagata K, Okamoto K<sup>#<\/sup>. A non-purine inhibitor of xanthine\r\n                      oxidoreductase mitigates adenosine triphosphate degradation under hypoxic conditions in mouse\r\n                      brain. 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Nasi S, Castelblanco M, Chobaz V, Ehirchiou D, So A, Bernabei I,\r\n                      <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Nishino T, Okamoto K,\r\n                      Busso N. Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in\r\n                      Osteoarthritic Damaged Cartilage. <em><strong>Front Cell Dev Biol<\/strong><\/em>. 2021 Feb\r\n                      9;9:612440. doi: 10.3389\/fcell.2021.612440.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">4. <span style=\"text-decoration: underline;\"><strong>Kusano\r\n                          T<\/strong><\/span>, Ehirchiou D, Matsumura T, Chobaz V, Nasi S, Castelblanco M, So A, Lavanchy\r\n                      C, Acha-Orbea H, Nishino T, Okamoto K#, Busso N. 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New Strategy\r\n                      That Delays Progression of Amyotrophic Lateral Sclerosis in G1H-G93A Transgenic Mice: Oral\r\n                      Administration of Xanthine Oxidoreductase Inhibitors That Are Not Substrates for the Purine\r\n                      Salvage Pathway. <em><strong>J Neuropathol Exp Neurol<\/strong><\/em>. 2016 Dec 1;75(12):1124-1144.\r\n                      doi: 10.1093\/jnen\/nlw088.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">6. Yamaguchi M, Okamoto K, <span\r\n                        style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Matsuda Y, Suzuki G, Fuse\r\n                      A, Yokota H. The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers\r\n                      following Global Brain Ischemia Reperfusion Injury in C57BL\/6 Mice. <em><strong>PLoS\r\n                          One<\/strong><\/em>. 2015 Jul 31;10(7):e0133980. doi: 10.1371\/journal.pone.0133980.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">7. Suzuki G, Okamoto K, <span\r\n                        style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Matsuda Y, Fuse A, Yokota\r\n                      H. 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Phosphorylation of Thr(1495) of nestin in a mouse model of\r\n                      cerebral ischemia and reperfusion damage. <em><strong>Pathol Int<\/strong><\/em>. 2013\r\n                      Sep;63(9):448-56. doi: 10.1111\/pin.12092.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">9. Kiran MD, Prakash JS, Annapoorni S, Dube S, <span\r\n                        style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Okuyama H, Murata N,\r\n                      Shivaji S. Psychrophilic Pseudomonas syringae requires trans-monounsaturated fatty acid for growth\r\n                      at higher temperature. <em><strong>Extremophiles<\/strong><\/em>. 2004 Oct;8(5):401-10. doi:\r\n                      10.1007\/s00792-004-0401-8.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">10. 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Molecular mechanism and physiological significance of\r\n                      dehydrogenase\/oxidase conversion of mammalian xanthine oxidoreductase. <em><strong>Gout and Uric\r\n                          &amp; Nucleic Acids<\/strong><\/em> 2024;48(1):1-10. doi:\r\n                      https:\/\/doi.org\/10.14867\/gnamtsunyo.48.1_1<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">15. Okamoto K, <span\r\n                        style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Nishino T. Chemical nature\r\n                      and reaction mechanisms of the molybdenum cofactor of xanthine oxidoreductase. <em><strong>Curr\r\n                          Pharm Des<\/strong><\/em>. 2013;19(14):2606-14. doi: 10.2174\/1381612811319140010.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br data-br=\"1\">\r\n                  <\/p>\r\n                  <h3 class=\"c-ttl\">\u52a9\u6559\u3000\u7247\u5c71 \u6620<\/h3>\r\n\r\n                  <p>\r\n                    <span style=\"color: #000000;\">1. Sugita Y, Kuwabara Y,&nbsp;<span\r\n                        style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,&nbsp;Matsuda S, Manabe\r\n                      I, Suzuki S, Oishi Y. 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Immunoproteomic identification of\r\n                      anti-C9 autoimmune antibody in patients with seronegative obstetric antiphospholipid syndrome.\r\n                      <em><strong>PLoS One<\/strong><\/em>. 2018 Jun 12;13(6):e0198472.\r\n                      doi:10.1371\/journal.pone.0198472.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br>\r\n                      6. Aoki M, Kang D,&nbsp;<span style=\"text-decoration: underline;\"><strong>Katayama\r\n                          A<\/strong><\/span>,&nbsp;Kuwahara N. Nagasaka S. Endo Y. Terasaki M. Kunugi S. Terasaki Y.\r\n                      Shimizu A. 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Gonadotropin\r\n                      regulation and role of ovarian osteopontin in the periovulatory period. <em><strong>J\r\n                          Endocrinol<\/strong><\/em>. 2015 Jul;224(1):49\u201359. doi:10.1530\/JOE-14-0203.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br>\r\n                      10. Okudela K,&nbsp;<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>.\r\n                      Woo T, Mitsui H, Suzuki T, Tateishi Y, Umeda S, Tajiri M, Masuda M, Nagahara N, Kitamura H, Ohashi\r\n                      K. 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Luo SS, Ishibashi O, Ishikawa G, Ishikawa T, <span\r\n                        style=\"text-decoration: underline;\"><strong>Katayama A,<\/strong><\/span> Mishima T, Takizawa T.\r\n                      Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal\r\n                      circulation via exosomes. <em><strong>Biol Reprod<\/strong><\/em>. 2009 Oct;81(4):717\u2013729.\r\n                      doi:10.1095\/biolreprod.108.075481<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br>\r\n                      14. 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Nagahara N, <span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>.\r\n                      Post-translational regulation of mercaptopyruvate sulfurtransferase via a low redox potential\r\n                      cysteine-sulfenate in the maintenance of redox homeostasis. <em><strong>J Biol Chem<\/strong><\/em>.\r\n                      2005 Nov 25;280(47):34569\u201334576. doi:10.1074\/jbc.M505643200.<br><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br data-br=\"1\"><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\">16. Kajisa T, Yoshida M, Igarashi K, <span\r\n                        style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>, Nishino T, Samejima M.\r\n                      Characterization and molecular cloning of cellobiose dehydrogenase from the brown-rot fungus\r\n                      Coniophora puteana. <em><strong>J Biosci Bioeng<\/strong><\/em>. 2004 Jul;98(1):57\u201363.\r\n                      doi.org\/10.1016\/S1389-1723(04)70242-X<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br>\r\n                      17. <span style=\"text-decoration: underline;\"><strong>Katayama A,<\/strong><\/span> Tsujii A, Wada\r\n                      A, Nishino T, Ishihama A<sup>.<\/sup> Systematic search for zinc-binding proteins in Escherichia\r\n                      coli. <em><strong>Eur J Biochem<\/strong><\/em>. 2002 May;269(10):2403\u20132413.\r\n                      doi:10.1046\/j.1432-1033.2002.02900.x.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br>\r\n                      18. <span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>, Fujita N,\r\n                      Ishihama A. Mapping of subunit-subunit contact surfaces on the \u03b2\u2032subunit of Escherichia coli RNA\r\n                      polymerase. <em><strong>J Biol Chem<\/strong><\/em>. 2000 Feb 4;275(5):3583\u20133592.\r\n                      doi:10.1074\/jbc.275.5.3583.<br><\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <span style=\"color: #000000;\"><br data-br=\"1\"><\/span>\r\n                  <\/p>\r\n                  <h3 class=\"c-ttl\">\u52a9\u6559\u3000\u677e\u6751 \u667a\u88d5<\/h3>\r\n\r\n                  <p>\r\n                    <span style=\"color: #000000;\">1. Bae SH<sup>*<\/sup>, Ikezono T<sup>*<\/sup>, Park HR, Kim H, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saito S, Maeda Y,\r\n                      Matsuda H, Jung J. Secretion of cochlin-tomoprotein (LCCL) in the middle ear following acute\r\n                      tympanic injury: implications for perilymph fistula diagnosis. <em><strong>Front\r\n                          Neurol<\/strong><\/em>. 2025 Apr 2; 16:1527311. doi: 10.3389\/fneur.2025.1527311.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">2. Sasaki A<sup>*<\/sup>, Ikezono T<sup>*<\/sup>, Matsuda H, Araki R,\r\n                      <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saitoh S, Wasano K,\r\n                      Matsubara A. Prevalence of perilymphatic fistula in patients with sudden-onset sensorineural\r\n                      hearing loss as diagnosed by Cochlin-tomoprotein (CTP) biomarker detection: its association with\r\n                      age, hearing severity, and treatment outcomes. <em><strong>Eur Arch\r\n                          Otorhinolaryngol<\/strong><\/em>. 2024 May;281(5):2373-2381. doi:\r\n                      10.1007\/s00405-023-08368-0.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">3. Noda S, Yamada A, Asawa Y, Nakamura H, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Orimo H, Goseki-Sone M.\r\n                      Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal\r\n                      Alkaline Phosphatase (ALPI) Gene. <em><strong>J Nutr Sci Vitaminol<\/strong><\/em> (Tokyo).\r\n                      2022;68(4):284-293. doi: 10.3177\/jnsv.68.284.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">4. Matsuda H, Tanzawa Y, Sekine T, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saito S, Shindo S,\r\n                      Usami SI, Kase Y, Itoh A, Ikezono T. Congenital Membranous Stapes Footplate Producing Episodic\r\n                      Pressure-Induced Perilymphatic Fistula Symptoms. <em><strong>Front Neurol<\/strong><\/em>. 2020 Nov\r\n                      10; 11:585747. doi: 10.3389\/fneur.2020.585747.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">5. Kusano T, Ehirchiou D, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Chobaz V, Nasi S,\r\n                      Castelblanco M, So A, Lavanchy C, Acha-Orbea H, Nishino T, Okamoto K, Busso N. Targeted knock-in\r\n                      mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.\r\n                      <em><strong>Nat Commun<\/strong><\/em>. 2019 Oct 28;10(1):4904. doi:\r\n                      10.1038\/s41467-019-12565-z.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">6. Uday S, <span style=\"text-decoration: underline;\"><strong>Matsumura\r\n                          T<\/strong><\/span>, Saraff V, Saito S, Orimo H, H\u00f6gler W. Tissue non- specific alkaline\r\n                      phosphatase activity and mineralization capacity of bi-allelic mutations from severe perinatal and\r\n                      asymptomatic hypophosphatasia phenotypes: Results from an in vitro mutagenesis model.\r\n                      <em><strong>Bone<\/strong><\/em>. 2019 Oct; 127:9-16. doi: 10.1016\/j.bone.2019.05.031.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">7. Ikezono T, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Matsuda H, Shikaze S,\r\n                      Saitoh S, Shindo S, Hasegawa S, Oh SH, Hagiwara Y, Ogawa Y, Ogawa H, Sato H, Tono T, Araki R,\r\n                      Maeda Y, Usami SI, Kase Y. The diagnostic performance of a novel ELISA for human CTP\r\n                      (Cochlin-tomoprotein) to detect perilymph leakage. <em><strong>PLoS One<\/strong><\/em>. 2018 Jan\r\n                      29;13(1):e0191498. doi: 10.1371\/journal.pone.0191498.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">8. Sekine K, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span><strong>,<\/strong>\r\n                      Takizawa T, Kimura Y, Saito S, Shiiba K, Shindo S, Okubo K, Ikezono T. Expression Profiling of\r\n                      MicroRNAs in the Inner Ear of Elderly People by Real-Time PCR Quantification. <em><strong>Audiol\r\n                          Neurootol<\/strong><\/em>. 2017;22(3):135-145. doi: 10.1159\/000479724.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">9. Matsuda H, Sakamoto K, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saito S, Shindo S,\r\n                      Fukushima K, Nishio SY, Kitoh R, Shibasaki O, Ito A, Araki R, Usami SI, Suzuki M, Ogawa K,\r\n                      Hasegawa T, Hagiwara Y, Kase Y, Ikezono T. A nationwide multicenter study of the Cochlin\r\n                      tomo-protein detection test: clinical characteristics of perilymphatic fistula cases.\r\n                      <em><strong>Acta Otolaryngol<\/strong><\/em>. 2017;137(sup565): S53-S59. doi:\r\n                      10.1080\/00016489.2017.1300940.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">10. <span style=\"text-decoration: underline;\"><strong>Matsumura\r\n                          T<\/strong><\/span>, Saito S, Orimo H. Immunofluorescence Labeling of a Mutant of Tissue\r\n                      Non-Specific Alkaline Phosphatase Lacking the Glysosylphosphatidylinositol Anchor. <em><strong>J\r\n                          Nippon Med Sch<\/strong><\/em>. 2016;83(4):140-1. doi: 10.1272\/jnms.83.140.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">11. Nishino T, Okamoto K, Kawaguchi Y, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Eger BT, Pai EF,\r\n                      Nishino T. The C-terminal peptide plays a role in the formation of an intermediate form during the\r\n                      transition between xanthine dehydrogenase and xanthine oxidase. <em><strong>FEBS J<\/strong><\/em>.\r\n                      2015 Aug;282(16):3075-90. doi: 10.1111\/febs.13277.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">12. Shiiba K, Shindo S, Ikezono T, Sekine K, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T,<\/strong><\/span> Sekiguchi S, Yagi T,\r\n                      Okubo K. Cochlin expression in the rat perilymph during postnatal development. <em><strong>Acta\r\n                          Otolaryngol<\/strong><\/em>. 2012 Nov;132(11):1134-9. doi: 10.3109\/00016489.2012.687456.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">13. Li L, Ikezono T, Sekine K, Shindo S, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Pawankar R, Ichimiya I,\r\n                      Yagi T. Molecular cloning of the Coch gene of guinea pig inner ear and its expression analysis in\r\n                      cultured fibrocytes of the spiral ligament. <em><strong>Acta Otolaryngol<\/strong><\/em>. 2010\r\n                      Aug;130(8):868-80. doi: 10.3109\/00016480903493766.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">14.&nbsp;Nagahara N, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Okamoto R, Kajihara Y.\r\n                      Protein cysteine modifications: (2) reactivity specificity and topics of medicinal chemistry and\r\n                      protein engineering. <em><strong>Curr Med Chem<\/strong><\/em>. 2009;16(34):4490-501. doi:\r\n                      10.2174\/092986709789760643.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">15. Sekine K, Ikezono T, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Shindo S, Watanabe A,\r\n                      Li L, Pawankar R, Nishino T, Yagi T. Expression of cochlin mRNA splice variants in the inner ear.\r\n                      <em><strong>Audiol Neurootol<\/strong><\/em>. 2010;15(2):88-96. doi: 10.1159\/000231634.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">16. <span style=\"text-decoration: underline;\"><strong>Matsumura\r\n                          T<\/strong><\/span>, Okamoto K, Iwahara SI, Hori H, Takahashi Y, Nishino T, Abe Y.\r\n                      Dimer-oligomer interconversion of wild-type and mutant rat 2-Cys peroxiredoxin: disulfide\r\n                      formation at dimer-dimer interfaces is not essential for decamerization. <em><strong>J Biol\r\n                          Chem<\/strong><\/em>. 2008 Jan 4;283(1):284-293. doi: 10.1074\/jbc.M705753200.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">17. Yamaguchi Y, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Ichida K, Okamoto K,\r\n                      Nishino T. Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon\r\n                      mutation of amino acid residues in the active site: roles of active site residues in binding and\r\n                      activation of purine substrate. <em><strong>J Biochem<\/strong><\/em>. 2007 Apr;141(4):513-24. doi:\r\n                      10.1093\/jb\/mvm053.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">18. Asai R, Nishino T, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Okamoto K, Igarashi K,\r\n                      Pai EF, Nishino T. Two mutations convert mammalian xanthine oxidoreductase to highly\r\n                      superoxide-productive xanthine oxidase. J Biochem. 2007 Apr;141(4):525-34. doi: 10.1093\/jb\/mvm054.\r\n                      <em><strong>Erratum in: J Biochem<\/strong><\/em>. 2008 Nov;144(5):691.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">19. Mine K, Katayama A, <span\r\n                        style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Nishino T, Kuwabara Y,\r\n                      Ishikawa G, Murata T, Sawa R, Otsubo Y, Shin S, Takeshita T. Proteome analysis of human placentae:\r\n                      pre-eclampsia versus normal pregnancy. <em><strong>Placenta<\/strong><\/em>. 2007 Jul;28(7):676-87.\r\n                      doi: 10.1016\/j.placenta.2006.10.005.<\/span>\r\n                  <\/p>\r\n                  <p>\r\n                    <br>\r\n                    <span style=\"color: #000000;\">20. Nagahara N, Yoshii T, Abe Y, <strong><span\r\n                          style=\"text-decoration: underline;\">Matsumura T<\/span><\/strong>. Thioredoxin-dependent\r\n                      enzymatic activation of mercaptopyruvate sulfurtransferase. An intersubunit disulfide bond serves\r\n                      as a redox switch for activation. <em><strong>J Biol Chem<\/strong><\/em>. 2007 Jan\r\n                      19;282(3):1561-9. doi: 10.1074\/jbc.M605931200.<\/span>\r\n                  <\/p>\r\n                <\/div>\r\n              <\/div>\r\n            <\/div>\r\n          <\/div>\r\n        <\/li>\r\n        <li class=\"accordion\">\r\n          <div class=\"acc-header\">\u6559\u5ba4\u30e1\u30f3\u30d0\u30fc<\/div>\r\n          <div class=\"acc-content\">\r\n            <div>\r\n              <h3 class=\"c-ttl\">\u5927\u5b66\u9662\u6559\u6388<\/h3>\r\n              <p>\r\n                \u4f50\u85e4\u3000\u3000\u5353\r\n              <\/p>\r\n            <\/div>\r\n            <div class=\"u-mt-40 u-mt-sp-30\">\r\n              <h3 class=\"c-ttl\">\u8b1b\u5e2b<\/h3>\r\n              <p>\r\n                \u5ca9\u5d0e\u3000\u4fca\u96c4<br>\u65e9\u5ddd\u3000\u6e05\u96c4\r\n              <\/p>\r\n            <\/div>\r\n            <div class=\"u-mt-40 u-mt-sp-30\">\r\n              <h3 class=\"c-ttl\">\u52a9\u6559<\/h3>\r\n              <p>\r\n                \u8349\u91ce\u3000\u8f1d\u7537<br>\u677e\u6751\u3000\u667a\u88d5\uff08URA\uff09<br>\u7247\u5c71\u3000\u3000\u6620\uff08\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u5206\u5b50\u89e3\u6790\u7814\u7a76\u5ba4\uff09\r\n              <\/p>\r\n            <\/div>\r\n            <div class=\"u-mt-40 u-mt-sp-30\">\r\n              <h3 class=\"c-ttl\">\u30c6\u30af\u30cb\u30ab\u30eb\u30fb\u30b5\u30dd\u30fc\u30c8\u30b9\u30bf\u30c3\u30d5<\/h3>\r\n              <p>\r\n                \u5ddd\u53e3\u3000\u88d5\u5b50<br>\u59cb\u95a2\u3000\u7d00\u7ae0 <\/p>\r\n            <\/div>\r\n            <div class=\"u-mt-40 u-mt-sp-30\">\r\n              <h3 class=\"c-ttl\">\u7814\u7a76\u88dc\u52a9\u54e1<\/h3>\r\n              <p>\r\n                \u6df1\u6fa4\u3000\u91cc\u6c99\u5b50\r\n              <\/p>\r\n            <\/div>\r\n            <div class=\"u-mt-40 u-mt-sp-30\">\r\n              <h3 class=\"c-ttl\">\u5927\u5b66\u9662\u751f<\/h3>\r\n              <p>\r\n                \u672c\u7530\u3000\u6893\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u5f62\u6210\u5916\u79d1\uff09\r\n                <br>\u6749\u91ce\u3000\u5065\u592a\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u814e\u81d3\u5185\u79d1\uff09\r\n                <br>\u6749\u7530\u3000\u6d0b\u4f51\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u7523\u5a66\u4eba\u79d1\uff09\r\n                <br>\u677e\u7530\u3000\u3000\u7e41\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u7523\u5a66\u4eba\u79d1\uff09\r\n              <\/p>\r\n            <\/div>\r\n          <\/div>\r\n        <\/li>\r\n\r\n      <\/ul>\r\n    <\/div>\r\n<\/section>","protected":false},"excerpt":{"rendered":"\u79c1\u305f\u3061\u306e\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09\u6559\u5ba4\uff08\u65e7\u751f\u5316\u5b66\u7b2c\u4e00\u8b1b\u5ea7\uff09\u306f\u30011936\u5e74\u306e\u5275\u7acb\u4ee5\u676580\u5e74\u4ee5\u4e0a\u306b\u4e98\u308a\u3001\u591a\u304f\u306e\u6307\u5c0e\u7684\u306a\u751f\u5316\u5b66\u8005\u3092\u8f29\u51fa\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u81e8\u5e8a\u304b\u3089\u5927\u5b66\u9662\u751f\u30fb\u7814\u7a76\u751f\u3092\u53d7\u3051\u5165\u308c\u3001\u512a\u308c\u305f\u81e8\u5e8a\u7814\u7a76 [&hellip;]","protected":false},"author":1,"featured_media":0,"parent":8,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-department.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-111","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/comments?post=111"}],"version-history":[{"count":34,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/111\/revisions"}],"predecessor-version":[{"id":4954,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/111\/revisions\/4954"}],"up":[{"embeddable":true,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/media?parent=111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}