{"id":111,"date":"2025-09-26T18:54:41","date_gmt":"2025-09-26T09:54:41","guid":{"rendered":"https:\/\/www.nms.ac.jp\/college\/?page_id=111"},"modified":"2026-06-11T16:02:28","modified_gmt":"2026-06-11T07:02:28","slug":"taisya-eiyougaku","status":"publish","type":"page","link":"https:\/\/www.nms.ac.jp\/college\/department\/kisoigaku\/taisya-eiyougaku\/","title":{"rendered":"\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09"},"content":{"rendered":"<section>\r\n<div class=\"inner\"><!-- <h3 class=\"pagettl u-ta-l\">\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09<\/h3> -->\r\n<div>\r\n<div class=\"prof\">\r\n<p>\u79c1\u305f\u3061\u306e\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09\u6559\u5ba4\uff08\u65e7\u751f\u5316\u5b66\u7b2c\u4e00\u8b1b\u5ea7\uff09\u306f\u30011936\u5e74\u306e\u5275\u7acb\u4ee5\u676580\u5e74\u4ee5\u4e0a\u306b\u4e98\u308a\u3001\u591a\u304f\u306e\u6307\u5c0e\u7684\u306a\u751f\u5316\u5b66\u8005\u3092\u8f29\u51fa\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u81e8\u5e8a\u304b\u3089\u5927\u5b66\u9662\u751f\u30fb\u7814\u7a76\u751f\u3092\u53d7\u3051\u5165\u308c\u3001\u512a\u308c\u305f\u81e8\u5e8a\u7814\u7a76\u8005\u3092\u80b2\u3066\u3066\u304d\u305f\u4f1d\u7d71\u3042\u308b\u6559\u5ba4\u3067\u3059\u3002 <br \/><br \/>\u3053\u306e\u9577\u3044\u6b74\u53f2\u306e\u4e2d\u3067\u3001\u5f53\u6559\u5ba4\u306f\u751f\u5316\u5b66\u9818\u57df\u306b\u304a\u3051\u308b\u57fa\u76e4\u7684\u304b\u3064\u5fdc\u7528\u7684\u306a\u8ab2\u984c\u306b\u53d6\u308a\u7d44\u3080\u3079\u304f\u3001\u4e00\u8cab\u3057\u3066\u86cb\u767d\u8cea\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3001\u86cb\u767d\u8cea\u76f8\u4e92\u4f5c\u7528\u3001\u5148\u5929\u6027\u4ee3\u8b1d\u7570\u5e38\u75c7\u306e\u539f\u56e0\u89e3\u660e\u3092\u8ef8\u306b\u3001\u591a\u304f\u306e\u56fd\u5185\u5916\u5171\u540c\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u5f53\u6559\u5ba4\u304c\u91cd\u70b9\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u305f\u4ee3\u8868\u7684\u7814\u7a76\u3068\u3057\u3066\u3001\uff081\uff09\u5148\u5929\u6027\u9aa8\u7cfb\u7d71\u75be\u60a3\u3067\u3042\u308b\u4f4e\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u75c7\u306b\u304a\u3051\u308b\u9aa8\u77f3\u7070\u5316\u969c\u5bb3\u306e\u5206\u5b50\u57fa\u76e4\u89e3\u660e\u3001\uff082\uff09\u91d1\u5c5e\u9175\u7d20\u304c\u95a2\u308f\u308b\u30ec\u30c9\u30c3\u30af\u30b9\u5fae\u7d30\u69cb\u9020\u6a5f\u80fd\u89e3\u6790\u3068\u5b89\u5b9a\u540c\u4f4d\u4f53\u30a2\u30df\u30ce\u9178\u30e9\u30d9\u30eb\u5c0e\u5165\u7528\u306e\u65b0\u898f\u5927\u8178\u83cc\u767a\u73fe\u5bbf\u4e3b\u682a\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u958b\u767a\u30fb\u516c\u958b\u3001\uff083\uff09\u75db\u98a8\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20\uff08Xanthine Oxidoreductase; XOR\uff09\u306b\u3088\u308b\u89e6\u5a92\u53cd\u5fdc\u30fb\u6d3b\u6027\u9178\u7d20\u7523\u751f\u6a5f\u69cb\u3001\u85ac\u5264\u7d50\u5408\u578b\u69cb\u9020\u306e\u89e3\u660e\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u7279\u306b\u3001XOR\u7814\u7a76\u306f\u6297\u75db\u98a8\u85ac\u3067\u3042\u308b\u30d5\u30a7\u30d6\u30ea\u30af\u3068\u30c8\u30d4\u30ed\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u3063\u305f\u793e\u4f1a\u7684\u306b\u3082\u30a4\u30f3\u30d1\u30af\u30c8\u306e\u5927\u304d\u3044\u7814\u7a76\u3067\u3059\u3002\u3044\u305a\u308c\u306e\u30c6\u30fc\u30de\u3082\u3001\u751f\u547d\u73fe\u8c61\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3001\u57fa\u790e\u751f\u5316\u5b66\u306e\u8996\u70b9\u3092\u8d77\u70b9\u3068\u3057\u3064\u3064\u3001\u30d2\u30c8\u75be\u60a3\u306e\u7406\u89e3\u3084\u3053\u308c\u3089\u306b\u5bfe\u3059\u308b\u6709\u52b9\u306a\u65b0\u898f\u6cbb\u7642\u30fb\u4e88\u9632\u6cd5\u306e\u958b\u767a\u3078\u3068\u3064\u306a\u304c\u308b\u9ad8\u3044\u6ce2\u53ca\u6027\u3092\u6301\u3064\u3082\u306e\u3067\u3059\u30022018\u5e74\u3088\u308a\u3001\u524d\u4efb\u306e\u5927\u77f3\u7531\u7f8e\u5b50\u6559\u6388\u3092\u4e2d\u5fc3\u306b\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u57fa\u76e4\u3092\u7d99\u627f\u30fb\u767a\u5c55\u3055\u305b\u3064\u3064\u3001\u73fe\u4ee3\u533b\u7642\u304c\u76f4\u9762\u3059\u308b\u52a0\u9f62\u95a2\u9023\u75be\u60a3\u3084\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u304c\u5c55\u958b\u3055\u308c\u3001\u9ad8\u5ea6\u30aa\u30df\u30af\u30b9\u89e3\u6790\u3084\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306a\u3069\u306e\u5148\u9032\u6280\u8853\u3092\u7528\u3044\u3001\u4ee3\u8b1d\u6052\u5e38\u6027\u306e\u7834\u7dbb\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u3053\u308c\u3089\u306e\u75be\u60a3\u767a\u75c7\u306b\u7d50\u3073\u3064\u304f\u306e\u304b\u304c\u7814\u7a76\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n<div class=\"prof-info\"><img decoding=\"async\" src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/img_prof.png\" alt=\"\u4f50\u85e4 \u5353\" \/>\r\n<p class=\"txt\">\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66(\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66) \/ <br \/>\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66<br \/>\u5927\u5b66\u9662\u6559\u6388\u3000 <span class=\"name\">\u4f50\u85e4 \u5353<\/span><\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"u-mt-40 u-mt-sp-30\">\r\n<p>2023\u5e7410\u6708\u3088\u308a\u4f50\u85e4\u304c\u5f53\u6559\u5ba4\u306e\u4e3b\u5bb0\u3092\u5f15\u304d\u7d99\u304e\u3001\u65b0\u305f\u306a\u7814\u7a76\u30c6\u30fc\u30de\u3068\u3057\u3066\u3001\u30d2\u30c8\u304c\u3093\u306b\u7279\u5316\u3057\u305f\u7814\u7a76\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002\u304c\u3093\u306f\u8a00\u3046\u307e\u3067\u3082\u306a\u304f\u3001\u73fe\u5728\u306b\u304a\u3044\u3066\u3082\u4e16\u754c\u7684\u306a\u4e3b\u8981\u6b7b\u56e0\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u75c7\u3084\u9032\u5c55\u306b\u95a2\u308f\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u3001\u73fe\u4ee3\u533b\u5b66\u306b\u304a\u3051\u308b\u6700\u91cd\u8981\u8ab2\u984c\u306e\u4e00\u3064\u3067\u3059\u3002\u751f\u5316\u5b66\u306f\u3001\u7d30\u80de\u5185\u3067\u8d77\u3053\u308b\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u73fe\u8c61\u3092\u5bfe\u8c61\u3068\u3059\u308b\u5b66\u554f\u3067\u3042\u308a\u3001\u304c\u3093\u3068\u3044\u3046\u8907\u96d1\u306a\u75c5\u614b\u3092\u6839\u672c\u304b\u3089\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u3001\u4e0d\u53ef\u6b20\u306a\u8996\u70b9\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u7d30\u80de\u5897\u6b96\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3001\u3055\u3089\u306b\u306f\u7d30\u80de\u9593\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u3044\u3063\u305f\u3001\u304c\u3093\u306e\u672c\u8cea\u306b\u95a2\u308f\u308b\u751f\u547d\u73fe\u8c61\u306f\u3001\u751f\u5316\u5b66\u7684\u624b\u6cd5\u306b\u3088\u308b\u89e3\u6790\u306a\u3057\u306b\u306f\u5341\u5206\u306b\u8a9e\u308c\u307e\u305b\u3093\u3002\u3068\u308a\u308f\u3051\u8fd1\u5e74\u3067\u306f\u3001\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3084\u3001\u7279\u5b9a\u306e\u4ee3\u8b1d\u9175\u7d20\u306e\u7570\u5e38\u767a\u73fe\u304c\u304c\u3093\u306e\u60aa\u6027\u5316\u3084\u6cbb\u7642\u62b5\u6297\u6027\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u751f\u5316\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u91cd\u8981\u6027\u306f\u304b\u3064\u3066\u306a\u3044\u307b\u3069\u306b\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002 <br \/><br \/>\u3053\u3046\u3057\u305f\u80cc\u666f\u3092\u8e0f\u307e\u3048\u3001\u5f53\u6559\u5ba4\u3067\u306f\u304c\u3093\u7814\u7a76\u306b\u304a\u3051\u308b\u751f\u5316\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u3055\u3089\u306a\u308b\u6df1\u5316\u3092\u76ee\u6307\u3057\u3001\u30e6\u30cb\u30fc\u30af\u306a\u7814\u7a76\u8cc7\u6e90\u3068\u3057\u3066\u300c\u60a3\u8005\u7531\u6765\u304c\u3093\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u300d\u3092\u6d3b\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5b9f\u969b\u306e\u60a3\u8005\u306e\u816b\u760d\u7d44\u7e54\u304b\u3089\u6a39\u7acb\u3055\u308c\u305f\u4e09\u6b21\u5143\u57f9\u990a\u304c\u3093\u7d30\u80de\u682a\u3067\u3042\u308a\u3001\u5f93\u6765\u306e\u304c\u3093\u7d30\u80de\u682a\u3068\u6bd4\u3079\u3001\u60a3\u8005\u306e\u816b\u760d\u672c\u6765\u306e\u6027\u8cea\u3092\u8a66\u9a13\u7ba1\u5185\u306b\u5fe0\u5b9f\u306b\u518d\u73fe\u3067\u304d\u308b\u70b9\u304c\u5927\u304d\u306a\u7279\u9577\u3067\u3059\u3002\u3053\u3046\u3057\u305f\u7d30\u80de\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u304c\u3093\u306b\u7279\u6709\u306e\u4ee3\u8b1d\u7d4c\u8def\u306e\u7570\u5e38\u3084\u3001\u85ac\u5264\u8010\u6027\u3092\u5f15\u304d\u8d77\u3053\u3059\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306a\u3069\u3001\u5f93\u6765\u306e\u624b\u6cd5\u3067\u306f\u6349\u3048\u304d\u308c\u306a\u304b\u3063\u305f\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001\u60a3\u8005\u7531\u6765\u304c\u3093\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u6211\u3005\u306e\u6700\u65b0\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b\u7279\u5b9a\u306e\u4ee3\u8b1d\u7d4c\u8def\u306e\u5909\u5316\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u3001\u3053\u308c\u304c\u304c\u3093\u306e\u518d\u767a\u3084\u60a3\u8005\u4e88\u5f8c\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\uff08Nakagawa &amp; Sato et al. Commun Biol. 8, 507 (2025), Sase &amp; Sato et al. Dev Cell. 60, 396-413.e6 (2025)\uff09\u3002\u4eca\u5f8c\u3082\u3053\u3046\u3057\u305f\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u7814\u7a76\u3092\u901a\u3058\u3066\u3001\u304c\u3093\u306e\u672c\u8cea\u306b\u8feb\u308b\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u7406\u89e3\u3092\u9032\u3081\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u69cb\u7bc9\u306b\u3064\u306a\u3052\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002 <br \/><br \/>\u672c\u5b66\u306e\u7279\u8272\u306e\u4e00\u3064\u306f\u3001\u81e8\u5e8a\u3068\u57fa\u790e\u7814\u7a76\u3068\u306e\u57a3\u6839\u304c\u4f4e\u304f\u3001\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3068\u306e\u5bc6\u306a\u9023\u643a\u306e\u3082\u3068\u3067\u7814\u7a76\u3092\u9032\u3081\u3089\u308c\u308b\u74b0\u5883\u306b\u3042\u308b\u70b9\u3067\u3059\u3002\u5b9f\u969b\u306e\u81e8\u5e8a\u73fe\u5834\u304b\u3089\u5f97\u3089\u308c\u308b\u77e5\u898b\u3084\u8ab2\u984c\u3092\u7814\u7a76\u306b\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3057\u3001\u57fa\u790e\u306e\u6210\u679c\u3092\u518d\u3073\u81e8\u5e8a\u306b\u9084\u5143\u3059\u308b\u300c\u30d9\u30f3\u30c1\u304b\u3089\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u3078\u3001\u305d\u3057\u3066\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u304b\u3089\u518d\u3073\u30d9\u30f3\u30c1\u3078\u300d\u3068\u3044\u3046\u53cc\u65b9\u5411\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u672c\u5b66\u306a\u3089\u3067\u306f\u306e\u5f37\u307f\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u74b0\u5883\u3067\u884c\u3046\u751f\u5316\u5b66\u7814\u7a76\u306f\u3001\u5358\u306a\u308b\u57fa\u790e\u7684\u77e5\u898b\u306e\u84c4\u7a4d\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u5b9f\u969b\u306e\u304c\u3093\u8a3a\u7642\u306b\u76f4\u7d50\u3059\u308b\u6210\u679c\u3092\u751f\u307f\u51fa\u3059\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002 <br \/><br \/>\u6211\u3005\u306f\u4eca\u5f8c\u3082\u3001\u751f\u5316\u5b66\u306e\u8996\u70b9\u304b\u3089\u69d8\u3005\u306a\u75be\u60a3\u306e\u672c\u8cea\u306b\u8feb\u308b\u7814\u7a76\u3092\u3055\u3089\u306b\u63a8\u9032\u3057\u3001\u65b0\u305f\u306a\u8a3a\u65ad\u30fb\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u3068\u3068\u3082\u306b\u3001\u6b21\u4e16\u4ee3\u306e\u7814\u7a76\u8005\u30fb\u533b\u7642\u4eba\u6750\u306e\u80b2\u6210\u306b\u3082\u7a4d\u6975\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u304d\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<div class=\"u-mt-80 u-mt-sp-60\">\r\n<ul class=\"acc-list\">\r\n<li class=\"accordion\">\r\n<div class=\"acc-header\">\u4e3b\u306a\u7814\u7a76\u5185\u5bb9<\/div>\r\n<div class=\"acc-content\">\r\n<div id=\"sec01\" class=\"sec_base\">\r\n<h3 class=\"c-ttl\">1. \u60a3\u8005\u7531\u6765\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3067\u6311\u3080\u3000\u30d2\u30c8\u304c\u3093\u306e\u89e3\u660e\u3068\u518d\u767a\u5236\u5fa1<\/h3>\r\n<p style=\"text-align: right;\"><span class=\"color\"><strong>\uff08\u5927\u5b66\u9662\u6559\u6388\u3000\u4f50\u85e4\u3000\u5353\uff09<\/strong><\/span><\/p>\r\n<p style=\"text-align: center;\"><\/p>\r\n<p>\u304c\u3093\u6cbb\u7642\u3067\u306f\u96c6\u5b66\u7684\u6cbb\u7642\u306b\u3088\u308a\u816b\u760d\u91cf\u3092\u4e00\u6642\u7684\u306b\u6291\u3048\u3089\u308c\u3066\u3082\u3001\u751f\u304d\u6b8b\u3063\u305f\u6cbb\u7642\u8010\u6027\u304c\u3093\u7d30\u80de\u304c\u518d\u767a\u306e\u539f\u56e0\u3068\u306a\u308a\u3001\u6cbb\u7642\u6210\u7e3e\u5411\u4e0a\u306e\u5927\u304d\u306a\u969c\u58c1\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3092\u793a\u3059\u7d30\u80de\u96c6\u56e3\u306e\u540c\u5b9a\u3068\u5236\u5fa1\u306f\u3001\u304c\u3093\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u4e3b\u8981\u56e0\u3067\u3042\u308b\u518d\u767a\u306e\u514b\u670d\u306b\u3064\u306a\u304c\u308a\u3001\u591a\u304f\u306e\u60a3\u8005\u306e\u9577\u671f\u4e88\u5f8c\u6539\u5584\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u52a0\u3048\u3066\u3001\u518d\u767a\u6291\u5236\u306b\u3088\u308b\u533b\u7642\u8cbb\u306e\u524a\u6e1b\u3001\u9577\u671f\u5165\u9662\u3084\u6cbb\u7642\u306b\u3088\u308b\u52b4\u50cd\u751f\u7523\u6027\u306e\u4f4e\u4e0b\u9632\u6b62\u3001\u50cd\u304d\u76db\u308a\u4e16\u4ee3\u306e\u793e\u4f1a\u5fa9\u5e30\u306e\u4fc3\u9032\u306a\u3069\u3001\u793e\u4f1a\u7d4c\u6e08\u7684\u306a\u6ce2\u53ca\u52b9\u679c\u3082\u6975\u3081\u3066\u5927\u304d\u3044\u3068\u3044\u3048\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u518d\u767a\u306e\u8d77\u70b9\u3068\u306a\u308b\u5fae\u5c0f\u907a\u6b8b\u816b\u760d\u306f\u3001\u3054\u304f\u5c11\u6570\u306e\u7d30\u80de\u3067\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u73fe\u5728\u306e\u753b\u50cf\u8a3a\u65ad\u6280\u8853\u3084\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u3067\u306f\u305d\u306e\u5b58\u5728\u3092\u6349\u3048\u308b\u3053\u3068\u306f\u3082\u3068\u3088\u308a\u3001\u305d\u306e\u6027\u8cea\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u3082\u6975\u3081\u3066\u56f0\u96e3\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u3053\u306e\u8ab2\u984c\u306b\u5bfe\u3057\u3001\u81e8\u5e8a\u533b\u3068\u9023\u643a\u3057\u3066\u60a3\u8005\u816b\u760d\u304b\u3089\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u69cb\u7bc9\u3057\u3001\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u3084\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\u3068\u3044\u3063\u305f\u5148\u9032\u7684\u306a\u6280\u8853\u3092\u99c6\u4f7f\u3059\u308b\u3053\u3068\u3067\u3001\u518d\u767a\u3092\u5f15\u304d\u8d77\u3053\u3059\u672c\u8cea\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u5f97\u3089\u308c\u305f\u77e5\u898b\u306b\u57fa\u3065\u3044\u3066\u3001\u304c\u3093\u518d\u767a\u3092\u4e88\u9632\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u5275\u51fa\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\r\n<p>&nbsp;<\/p>\r\n<p><img decoding=\"async\" class=\"gazou-max\" src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Sato_Figure_PNG.png\" alt=\"Sato_Figure_PNG\" \/><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u53c2\u8003\u8ad6\u6587<\/p>\r\n<p>1) Nakagawa S*, Sato T<sup>*#<\/sup> et al. Commun Biol. 8, 507. (2025) (<sup>*<\/sup>:equal contribution, <sup>#<\/sup>: co-corresponding)<br \/>2) Sase M<sup>*<\/sup>, Sato T<sup>*<\/sup> et al. Dev Cell. 60, 396-413.e6. (2025) (<sup>*<\/sup>:equal contribution)<br \/>3) Sato T et al. Nat Cell Biol. 22, 919-926. (2020)<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">2. \u91d1\u5c5e\u9175\u7d20\u306e\u69cb\u9020\u6a5f\u80fd\u89e3\u6790\u3068\u5927\u8178\u83cc\u30a2\u30df\u30ce\u9178\u8981\u6c42\u6027\u767a\u73fe\u5bbf\u4e3b\u682a\u958b\u767a<\/h3>\r\n<p style=\"text-align: right;\"><span class=\"color\"><strong>\uff08\u8b1b\u5e2b\u3000\u5ca9\u5d0e \u4fca\u96c4\uff09<\/strong><\/span><\/p>\r\n<p>\u7814\u7a76\u5185\u5bb9\u30fb\u696d\u7e3e\u7b49\u306e\u59d4\u7d30\u306b\u3064\u3044\u3066\u306f\u3001\u30ea\u30f3\u30af\u5148\u306e\u7814\u7a76\u30db\u30fc\u30e0\u30da\u30fc\u30b8<br \/><a href=\"http:\/\/fesworld.jp\/\" class=\"txtlink\" target=\"_blank\" rel=\"noopener\">https:\/\/fesworld.jp\/<\/a> \u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u53c2\u8003\u8ad6\u6587<br \/>1) Iwasaki T et al. J. Am. Chem. Soc. 131, 13659-13667. (2009)<br \/>2) Iwasaki T et al. J. Am. Chem. Soc. 134, 19731-19738. (2012)<br \/>3) Iwasaki T et al. J. Biochem. (Review) 169, 387-394. (2021)<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">3. \u98df\u54c1\u56e0\u5b50\u304c\u95a2\u308f\u308b\u300c\u81ea\u7136\u514d\u75ab\u30b7\u30b0\u30ca\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u300d\u306e\u3057\u304f\u307f\u3092\u89e3\u304d<\/h3>\r\n<p><span class=\"color\"><strong>\u660e\u304b\u3059 \uff5e\u611f\u67d3\u75c7\u30fb\u304c\u3093\u30fb\u708e\u75c7\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4f53\u306e\u9632\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63a2\u308b\uff5e<\/strong><\/span><\/p>\r\n<p style=\"text-align: right;\"><span class=\"color\"><strong><span style=\"font-size: 14pt;\">\uff08\u8b1b\u5e2b\u3000\u65e9\u5ddd \u6e05\u96c4\uff09<\/span><\/strong><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u79c1\u305f\u3061\u306e\u4f53\u306b\u306f\u3001\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u3001\u304c\u3093\u7d30\u80de\u306a\u3069\u306e\u201c\u5916\u6575\u201d\u304b\u3089\u8eab\u3092\u5b88\u308b\u305f\u3081\u306e\u4ed5\u7d44\u307f\u304c\u5099\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001\u6700\u524d\u7dda\u3067\u50cd\u304f\u306e\u304c\u300c\u81ea\u7136\u514d\u75ab\uff08\u3057\u305c\u3093\u3081\u3093\u3048\u304d\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002<br \/>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u98df\u54c1\u56e0\u5b50\u304c\u3001\u81ea\u7136\u514d\u75ab\u306e\u50cd\u304d\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3059\u308b\u306e\u304b\u3092\u3001\u7d30\u80de\u306e\u60c5\u5831\u4f1d\u9054\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08\uff1d\u30b7\u30b0\u30ca\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff09\u306b\u7740\u76ee\u3057\u3066\u3001\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\u81ea\u7136\u514d\u75ab\u306f\u3001\u611f\u67d3\u75c7\u3001\u304c\u3093\u3001\u6162\u6027\u708e\u75c7\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u75c5\u6c17\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u3082\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u98df\u54c1\u56e0\u5b50\u304c\u81ea\u7136\u514d\u75ab\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u5c06\u6765\u7684\u306a\u75c5\u6c17\u306e\u4e88\u9632\u3084\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p>&nbsp;<\/p>\r\n<p><img decoding=\"async\" class=\"gazou-max\" src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Hayakawa_Figure_small.png\" alt=\"Hayakawa_Figure_small\" title=\"\" \/><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u53c2\u8003\u8ad6\u6587<br \/>1) Hayakawa S et al. JCI Insight. 7, e138539. (2022)<br \/>2) Hayakawa S*, Shiratori S* et al. Nat. Immunol. 12, 37-44. (2011) (*:equal contribution)<br \/>3) Takaoka A, Hayakawa S et al. Nature. 424, 516-523. (2003)<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">4. \u54fa\u4e73\u985e\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20<\/h3>\r\n<p><span class=\"color\">\u8131\u6c34\u7d20\u9175\u7d20 \/ \u9178\u5316\u9175\u7d20\u5909\u63db\u306e\u5206\u5b50\u6a5f\u69cb\u3068\u751f\u7406\u7684\u610f\u7fa9<\/span><\/p>\r\n<p style=\"text-align: right;\"><span class=\"color\"><strong>\uff08\u52a9\u6559\u3000\u8349\u91ce \u8f1d\u7537\uff09<\/strong><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20\uff08XOR\uff09\u306f\u5206\u5b50\u5185\u306b\u30e2\u30ea\u30d6\u30c9\u30d7\u30c6\u30ea\u30f3\u3001\u9244\u786b\u9ec4\u4e2d\u5fc3\u3001FAD\u3092\u542b\u3080\u91d1\u5c5e\u30d5\u30e9\u30d3\u30f3\u9175\u7d20\u3067\u3059\u3002\u751f\u4f53\u5185\u3067\u306f\u30d2\u30c8\u306e\u30d7\u30ea\u30f3\u4ee3\u8b1d\u306e\u6700\u7d42\u30b9\u30c6\u30c3\u30d7\u3092\u89e6\u5a92\u3059\u308b\u5c3f\u9178\u7523\u751f\u9175\u7d20\u3068\u3057\u3066\u50cd\u304d\u3001\u75db\u98a8\u6cbb\u7642\u85ac\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u751f\u4f53\u5185\u3067\u6d3b\u6027\u9178\u7d20\u3092\u7523\u751f\u3059\u308b\u5206\u5b50\u3068\u3057\u3066\u3001\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u591a\u304f\u306e\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u3001\u81e8\u5e8a\u533b\u5b66\u7684\u306b\u3082\u91cd\u8981\u3067\u3059<sup>1)<\/sup>\u3002\u54fa\u4e73\u985e XOR \u306e\u7279\u5fb4\u3068\u3057\u3066\u6d3b\u6027\u5909\u63db\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002XOR\u306f\u901a\u5e38\u306f\u8131\u6c34\u7d20\u9175\u7d20\u6d3b\u6027\u3092\u793a\u3057\u3001\u5c3f\u9178\u751f\u6210\u306b\u3068\u3082\u306a\u3044 NADH \u3092\u7523\u751f\u3057\u307e\u3059\u304c\u3001\u69cb\u9020\u5909\u5316\u3092\u304a\u3053\u3057\u9178\u5316\u9175\u7d20\u578b\u306b\u5909\u63db\u3055\u308c\u308b\u3068\u6d3b\u6027\u9178\u7d20\u3092\u7523\u751f\u3057\u307e\u3059\u3002\u3053\u306e\u6d3b\u6027\u5909\u63db\u306f\u3001\u5f93\u6765\u306f\u708e\u75c7\u3084\u969c\u5bb3\u3055\u308c\u305f\u7d44\u7e54\u306a\u3069\u306b\u8d77\u3053\u308b\u75c5\u7406\u7684\u306a\u73fe\u8c61\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u6700\u8fd1\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u4e73\u6c41\u3084\u53e3\u8154\u7c98\u819c\u3067\u306f\u4ed6\u306e\u5206\u5b50\u3068\u5354\u8abf\u3057\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5c40\u6240\u514d\u75ab\u306e\u4e00\u74b0\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f3\uff09<sup>2)<\/sup>\u3002\u3053\u306e\u81ea\u7136\u514d\u75ab\u6a5f\u69cb\u306f XOR \u306e\u6d3b\u6027\u5909\u63db\u3092\u30c8\u30ea\u30ac\u30fc\u3068\u3057\u3066\u304a\u308a\u3001\u75db\u98a8\u6cbb\u7642\u85ac\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u3066\u3044\u308b XOR \u963b\u5bb3\u5264\u3067\u6297\u83cc\u4f5c\u7528\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u305f\u3081\u3001\u73fe\u5728\u306f\u81e8\u5e8a\u5fdc\u7528\u306b\u3064\u306a\u3052\u308b\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\r\n<p>&nbsp;<\/p>\r\n<p><img decoding=\"async\" class=\"gazou-max\" src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Kusano_Figure_small.png\" alt=\"Kusano_Figure_small\" title=\"\" \/><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u53c2\u8003\u6587\u732e<br \/>1) Kusano T et al. Redox Biol. 59, 102573.(2023)<br \/>2) Kusano T et al. Nat Commun. 10, 4904. (2019)<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">5.\u00a0\u30cd\u30aa\u30fb\u30bb\u30eb\u30d5\u6297\u4f53\u7523\u751f\u306b\u3088\u308b\u81ea\u5df1\u6297\u4f53\u306e\u63a2\u7d22\u3068\u3001\u9838\u7ba1\u719f\u5316\u6a5f\u69cb\u306e\u89e3\u660e<\/h3>\r\n<p style=\"text-align: right;\"><span class=\"color\"><strong>\uff08\u52a9\u6559\u3000\u7247\u5c71 \u6620\uff09<\/strong><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u30fb\u6d41\u7523\u30fb\u6b7b\u7523\u3092\u53cd\u5fa9\u3059\u308b\u4e0d\u80b2\u75c7\u60a3\u8005\u306e\u3046\u3061\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u75c7\u72b6\u3092\u793a\u3059\u304c\u3001\u75c5\u56e0\u304c\u4e0d\u660e\u306a\u60a3\u8005\u304c\u5b58\u5728\u3059\u308b\u3002\u975e\u514d\u75ab\u7d30\u80de\u7531\u6765\u306e\u30cd\u30aa\u30fb\u30bb\u30eb\u30d5\u6297\u539f\uff0d\u6297\u4f53\u306f\u3001\u53e4\u5178\u7684\u306a\u9069\u5fdc\u514d\u75ab\u306e\u958b\u59cb\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u306f\u7570\u306a\u308b\u7523\u751f\u6a5f\u69cb\u3067\u767a\u73fe\u3057\u3001\u305d\u306e\u4e00\u90e8\u306f\u4e0d\u80b2\u75c7\u306e\u75c5\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u3001\u672a\u77e5\u306e\u81ea\u5df1\u6297\u539f\u306e\u63a2\u7d22\u3068\u3057\u3066\u3001iPS\u7d30\u80de\u3084\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u306b\u3088\u308b\u30cd\u30aa\u30fb\u30bb\u30eb\u30d5\u6297\u4f53\u7523\u751f\u6a5f\u69cb\u306b\u57fa\u3065\u3044\u305f\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u308b(\u56f31)\u3002\u73fe\u5728\u3001\u708e\u75c7\u523a\u6fc0\u306b\u3088\u308a\u3001\u7d30\u80de\u8868\u9762\u306b\u63d0\u793a\u308c\u305fMHC\u30af\u30e9\u30b92\u8907\u5408\u4f53\u306b\u542b\u307e\u308c\u308b\u6297\u539f\u5019\u88dc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u540c\u5b9a\u6cd5\u3092\u78ba\u7acb\u3057\u3001\u3055\u3089\u306b\u60a3\u8005\u691c\u4f53\u3078\u306e\u9069\u5fdc\u3092\u9032\u3081\u3066\u3044\u308b\u3002<\/p>\r\n<p>\u30fb\u598a\u5a20\u4e2d\u671f\u3088\u308a\u9838\u7ba1\u719f\u5316\u304c\u9032\u307f\u65e9\u7523\u3068\u306a\u308b\u75c5\u614b\u306f\u3001\u598a\u5a20\u306e\u7dad\u6301\u306b\u95a2\u308f\u308b\u30db\u30eb\u30e2\u30f3\u306e\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3(P4)\u306e\u611f\u53d7\u6027\u304c\u8981\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u308b\u3002\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u9838\u7ba1\u3092\u69cb\u6210\u3059\u308b\u4e3b\u8981\u306a\u7d30\u80de\u3067\u3001P4\u53d7\u5bb9\u4f53\u306b\u3088\u308b\u8ee2\u5199\u8abf\u7bc0\u6a5f\u69cb\u306b\u3088\u308a\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30af\u30b9\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3002\u65e9\u7523\u6642\u306e\u9838\u7ba1\u719f\u5316\u306e\u5206\u5b50\u6a5f\u69cb\u306b\u3064\u3044\u3066\u3001\u60a3\u8005\u691c\u4f53\u7531\u6765\u306e\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u305f\u89e3\u660e\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\r\n<p>&nbsp;<\/p>\r\n<p><img decoding=\"async\" class=\"gazou-max\" src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Katayama_Figure.jpg\" alt=\"Katayama_Figure\" title=\"\" \/><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u53c2\u8003\u6587\u732e<br \/>1) Kuwabara Y, Katayama A, et al. PLOS one. 13, e0198472. (2018)<br \/>2) Kuwabara Y, Katayama A, et al. Am J Reprod Immunol. 78 (2017)<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">6.\u00a0\u907a\u4f1d\u6027\u75be\u60a3\u306b\u95a2\u308f\u308b\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u3092\u3082\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020<span style=\"font-size: 12pt;\">\u30fb<\/span>\u6a5f\u80fd\u89e3\u6790<\/h3>\r\n<p style=\"text-align: right;\"><span class=\"color\"><strong>\uff08\u52a9\u6559\u3000\u677e\u6751 \u667a\u88d5\uff09<\/strong><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7acb\u4f53\u69cb\u9020\u304c\u6b63\u3057\u304f\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3067\u7279\u5b9a\u306e\u6a5f\u80fd\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9ad8\u6b21\u69cb\u9020\uff08\u4e09\u6b21\u3001\u56db\u6b21\u69cb\u9020\uff09\u3092\u69cb\u6210\u3059\u308b\u91cd\u8981\u306a\u5316\u5b66\u7d50\u5408\u306b\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\uff08S-S \u7d50\u5408\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u5206\u5b50\u5185\uff08\u4e09\u6b21\u69cb\u9020\uff09\u3042\u308b\u3044\u306f\u5206\u5b50\u9593\uff08\u56db\u6b21\u69cb\u9020\uff09\u306eS-S \u7d50\u5408\u304c\u53ef\u9006\u7684\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u3067\u6a5f\u80fd\u304c\u5909\u5316\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7740\u76ee\u3057\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\u7814\u7a76\u3092\u59cb\u3081\u308b\u304d\u3063\u304b\u3051\u3068\u306a\u3063\u305fXanthine Oxidoreductase (XOR)\u306f\u3001\u5206\u5b50\u5185S-S \u7d50\u5408\u306e\u6709\u7121\u3067\u9178\u5316\u9175\u7d20\u304b\u3089\u8131\u6c34\u7d20\u9175\u7d20\u3078\u3068\u53ef\u9006\u7684\u306b\u5909\u63db\u3055\u308c\u308b\u3053\u3068\u304c\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305fPeroxiredoxin I (Prx I)\u306f\u3001\u4e8c\u91cf\u4f53\u3068\u5341\u91cf\u4f53\u306e2\u3064\u306e\u69cb\u9020\u306b\u3088\u3063\u3066\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u6d3b\u6027\u304c\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u3001\u5206\u5b50\u9593\u306eS-S \u7d50\u5408\u306b\u95a2\u308f\u308bCys\u6b8b\u57fa\u306e\u5909\u7570\u4f53\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306b\u3064\u3044\u3066\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306eX\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u306b\u3082\u6210\u529f\u3057\u3066\u3044\u307e\u3059(1, 2)\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u6027\u75be\u60a3\u306b\u95a2\u308f\u308b\u30a2\u30eb\u30ab\u30ea\u30d5\u30a9\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\uff08ALP\uff09\u3068\u30b3\u30af\u30ea\u30f3\uff08Cochlin\uff09\u306b\u7740\u76ee\u3057\u3066\u69cb\u9020\u30fb\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7d44\u7e54\u975e\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308bALP\u306f\u5206\u5b50\u5185S-S \u7d50\u5408\u304c1\u30ab\u6240\u5b58\u5728\u3057\u3001\u3053\u306eCys\u6b8b\u57fa\u304c\u5909\u7570\u3059\u308b\u3068\u6d3b\u6027\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u3066\u4f4e\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u75c7\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30b3\u30af\u30ea\u30f3\u306f\u5185\u8033\u306b\u7279\u306b\u591a\u304f\u767a\u73fe\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u907a\u4f1d\u6027\u96e3\u8074DFNA9\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002N-\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u304c\u5207\u65ad\u3055\u308c\u305fCochlin tomo-protein (CTP)\u306f\u5185\u8033\u306e\u5916\u30ea\u30f3\u30d1\u306b\u7279\u306b\u591a\u304f\u5206\u6ccc\u3055\u308c\u3066\u3044\u307e\u3059(3)\u3002CTP\u306f\u5916\u30ea\u30f3\u30d1\u763b\u75be\u60a3\u3092\u9451\u5225\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f53\u5916\u8a3a\u65ad\u85ac\u304c\u958b\u767a\u3055\u308c2022\u5e74\u306b\u4fdd\u967a\u53ce\u8f09\u3055\u308c\u307e\u3057\u305f\u3002CTP\u306b\u306f\u4fdd\u5b58\u6027\u306e\u9ad8\u30444\u3064\u306eCys\u6b8b\u57fa\u304c\u5b58\u5728\u3057\u3001\u5206\u5b50\u5185\u30672\u7d44\u306eS-S \u7d50\u5408\u304c\u5f62\u6210\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u308c\u3089ALP\u3084CTP\u306b\u3064\u3044\u3066\u3001\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305fin vitro\u30ea\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u624b\u6cd5\u3092\u4e00\u3064\u306e\u8db3\u304c\u304b\u308a\u3068\u3057\u3066\u3001S-S \u7d50\u5408\u304c\u6301\u3064\u91cd\u8981\u306a\u6a5f\u80fd\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p>&nbsp;<\/p>\r\n<p><img decoding=\"async\" class=\"gazou-max\" src=\"..\/..\/..\/assets\/images\/classroom\/kisoigaku\/taisya-eiyougaku\/Matsumura_Figure.png\" alt=\"Matsumura_Figure\" title=\"\" \/><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u53c2\u8003\u6587\u732e<\/p>\r\n<p>1) Yamaguchi Y, Matsumura T, et al. J. Biochem. 141, 513-24. (2007).<br \/>2) Matsumura T, et al. J. Biol. Chem. 283, 284-93. (2008).<br \/>3) Ikezono T, Matsumura T, et al. PLoS One. 13, e0191498. (2018)<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/li>\r\n<li class=\"accordion\">\r\n<div class=\"acc-header\">\u4e3b\u306a\u767a\u8868\u8ad6\u6587<\/div>\r\n<div class=\"acc-content\">\r\n<div>\r\n<div class=\"sec_base\">\r\n<div>\r\n<h3 class=\"c-ttl\">\u5927\u5b66\u9662\u6559\u6388\u3000\u4f50\u85e4 \u5353<\/h3>\r\n<p><span style=\"color: #000000;\">1. <strong><span style=\"text-decoration: underline;\">Sato T<\/span><\/strong>. Role of Patient-Derived Tumor Organoids in Advanced Cancer Research. J Nippon Med Sch. 2025;92(3):234-241. doi: 10.1272\/jnms.JNMS.2025_92-310. (Review)<\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\">2. Nakagawa S*, <strong><span style=\"text-decoration: underline;\">Sato T<sup>*<\/sup><\/span><\/strong>, Ohashi E*, Kajita M*, Miya F, Yamamoto K, Yotsumata H, Yamaguchi K, Nakajima Y, Miura A, Kinugasa Y, Ohteki T. An organoid library of human esophageal squamous cell carcinomas (ESCCs) uncovers the chemotherapy-resistant ESCC features. <em><strong>Commun Biol.<\/strong><\/em> 2025 Apr 1;8(1):507. doi: 10.1038\/s42003-025-07869-4. (*: equal contribution, #: Co-corresponding author)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>3. Sase M*, <span style=\"text-decoration: underline;\"><strong>Sato T<sup>*<\/sup><\/strong><\/span>, Sato H, Miya F, Zhang S, Haeno H, Kajita M, Noguchi T, Mori Y, Ohteki T. Comparative analysis of tongue cancer organoids among patients identifies the heritable nature of minimal residual disease. <em><strong>Dev Cell.<\/strong><\/em> 2025 Feb 3;60(3):396-413.e6. doi: 10.1016\/j.devcel.2024.10.007. (*: equal contribution)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>4. Kanayama M, Izumi Y, Akiyama M, Hayashi T, Atarashi K, Roers A, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ohteki T. Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. <em><strong>J Exp Med<\/strong><strong>.<\/strong><\/em> 2023 Apr 3;220(4):e20221221. doi: 10.1084\/jem.20221221.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>5. Minamide K*, <span style=\"text-decoration: underline;\"><strong>Sato T<sup>*<\/sup><\/strong><\/span>, Nakanishi Y, Ohno H, Kato T, Asano J, Ohteki T. IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. <em><strong>Sci Rep.<\/strong><\/em> 2020 Sep 8;10(1):14639. doi: 10.1038\/s41598-020-71633-3. (*: equal contribution)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>6. <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T. Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. <em><strong>Nat Cell Biol.<\/strong><\/em> 2020 Aug;22(8):919-926. doi: 10.1038\/s41556-020-0545-5.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>7. <span style=\"text-decoration: underline;\"><strong>Sato T<sup>*<\/sup><\/strong><\/span>, Sase M*, Ishikawa S, Kajita M, Asano J, Sato T, Mori Y, Ohteki T. Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. <em><strong>Sci Rep.<\/strong><\/em> 2020 May 22;10(1):8308. doi: 10.1038\/s41598-020-64987-1. (*: equal contribution)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>8. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Kajita M, Ohteki T. CD86-based analysis enables observation of bona fide hematopoietic responses. <em><strong>Blood.<\/strong><\/em> 2020 Sep 3;136(10):1144-1154. doi: 10.1182\/blood.2020004923.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>9. Nakanishi Y, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Takahashi K, Ohteki T. IFN-\u03b3-dependent epigenetic regulation instructs colitogenic monocyte\/macrophage lineage differentiation in vivo. <em><strong>Mucosal Immunol.<\/strong><\/em> 2018 May;11(3):871-880. doi: 10.1038\/mi.2017.104.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>10. Kawamura S, Onai N, Miya F, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Tsunoda T, Kurabayashi K, Yotsumoto S, Kuroda S, Takenaka K, Akashi K, Ohteki T. Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. <em><strong>Immunity.<\/strong><\/em> 2017 May 16;46(5):835-848.e4. doi: 10.1016\/j.immuni.2017.04.019.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>11. Asano J, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ichinose S, Kajita M, Onai N, Shimizu S, Ohteki T. Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. <em><strong>Cell Rep.<\/strong><\/em> 2017 Aug 1;20(5):1050-1060. doi: 10.1016\/j.celrep.2017.07.019.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>12. Yokoi T, Yokoi K, Akiyama K, Higuchi T, Shimada Y, Kobayashi H, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ohteki T, Otsu M, Nakauchi H, Ida H, Ohashi T. Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II. <em><strong>Mol Genet Metab.<\/strong><\/em> 2016 Nov;119(3):232-238. doi: 10.1016\/j.ymgme.2016.08.003.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>13. Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, Takubo K. Bacterial c-di-GMP affects hematopoietic stem\/progenitors and their niches through STING. <em><strong>Cell Rep.<\/strong><\/em> 2015 Apr 7;11(1):71-84. doi: 10.1016\/j.celrep.2015.02.066.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>14. Nakanishi Y, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ohteki T. Commensal Gram-positive bacteria initiates colitis by inducing monocyte\/macrophage mobilization. <em><strong>Mucosal Immunol.<\/strong><\/em> 2015 Jan;8(1):152-60. doi: 10.1038\/mi.2014.53.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>15. <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Ikeda M, Yotsumoto S, Shimada Y, Higuchi T, Kobayashi H, Fukuda T, Ohashi T, Suda T, Ohteki T. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. <em><strong>Blood.<\/strong><\/em> 2013 Apr 18;121(16):3267-73. doi: 10.1182\/blood-2012-07-443713.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>16. Ohyagi H, Onai N, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, M\u00fcller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, Ohteki T. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. <em><strong>Immunity.<\/strong><\/em> 2013 Sep 19;39(3):584-98. doi: 10.1016\/j.immuni.2013.06.019.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>17. Mashima H, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Horie Y, Nakagawa Y, Kojima I, Ohteki T, Ohnishi H. Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. <em><strong>Gastroenterology.<\/strong><\/em> 2011 Sep;141(3):1102-1113.e1-8. doi: 10.1053\/j.gastro.2011.05.051.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>18. Tezuka H, Abe Y, Asano J, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Liu J, Iwata M, Ohteki T. Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. <em><strong>Immunity.<\/strong><\/em> 2011 Feb 25;34(2):247-57. doi: 10.1016\/j.immuni.2011.02.002.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>19. Asano J, Tada H, Onai N, <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Horie Y, Fujimoto Y, Fukase K, Suzuki A, Mak TW, Ohteki T. Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. <em><strong>J Immunol.<\/strong><\/em> 2010 Jan 15;184(2):736-45. doi: 10.4049\/jimmunol.0900726. Epub 2009 Dec 11.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>20. <span style=\"text-decoration: underline;\"><strong>Sato T<\/strong><\/span>, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. <em><strong>Nat Med.<\/strong><\/em> 2009 Jun;15(6):696-700. doi: 10.1038\/nm.1973.<\/span><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">\u8b1b\u5e2b\u3000\u5ca9\u5d0e \u4fca\u96c4<\/h3>\r\n<p><span style=\"color: #000000;\">1. Boos JR,\u00a0Jandrain HN, Hagiuda E, Taguchi AT, Hasegawa K, Fedun BL, Taylor SJ, Elad SM, Faber SE, Kumasaka T, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Geldenhuys WJ. Structure and biological evaluation of Caenorhabditis elegansCISD-1\/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response. <em><strong>Adv Redox Res.<\/strong><\/em> 2022 Dec;6:100048. doi: 10.1016\/j.arres.2022.100048. (Co-corresponding author)<\/span><\/p>\r\n<p><span style=\"color: #000000;\">\u00a0<\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\">2. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,\u00a0Miyajima-Nakano Y, Fukazawa R, Lin MT, Matsushita SI, Hagiuda E, Taguchi AT, Dikanov SA, Oishi Y, Gennis RB. Escherichia coli amino acid auxotrophic expression host strains for investigating protein structure-function relationships. <em><strong>J Biochem.<\/strong><\/em> 2021 Apr 29;169(4):387-394. doi: 10.1093\/jb\/mvaa140. (Corresponding author)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>3. Geldenhuys WJ,\u00a0Long TE, Saralkar P, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Nu\u00f1ez RAA, Nair RR, Konkle ME, Menze MA, Pinti MV, Hollander JM, Hazlehurst LA, Robart AR. Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand. <em><strong>Commun Chem.<\/strong><\/em> 2019;2:77. doi: 10.1038\/s42004-019-0172-x.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>4. Taguchi AT,\u00a0Ohmori D, Dikanov SA, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>. g-Tensor Directions in the Protein Structural Frame of Hyperthermophilic Archaeal Reduced Rieske-Type Ferredoxin Explored by 13C Pulsed Electron Paramagnetic Resonance. <em><strong>Biochemistry.<\/strong><\/em> 2018 Jul 17;57(28):4074-4082. doi: 10.1021\/acs.biochem.8b00438. (Co-corresponding author)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>5. Taguchi AT, Miyajima-Nakano Y, Fukazawa R, Lin MT, Baldansuren A, Gennis RB, Hasegawa K, Kumasaka T, Dikanov SA,<\/span><\/span> <span color=\"#000000\"><span style=\"font-size: 13.3333px;\"><span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>.<\/span><\/span>\u00a0<span style=\"color: #000000;\">Unpaired Electron Spin Density Distribution across Reduced [2Fe-2S] Cluster Ligands by 13Cb-Cysteine Labeling. <strong><em>Inorg Chem.<\/em><\/strong> 2018 Jan 16;57(2):741-746. doi: 10.1021\/acs.inorgchem.7b02676. (Co-corresponding author)<\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>6. Lin MT, Fukazawa R, Miyajima-Nakano Y, Matsushita S, Choi SK, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,\u00a0Gennis RB. Escherichia coli auxotroph host strains for amino acid-selective isotope labeling of recombinant proteins. <em><strong>Methods Enzymol.<\/strong><\/em> 2015;565:45-66. doi: 10.1016\/bs.mie.2015.05.012. (Co-corresponding author)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>7. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Fukazawa R, Miyajima-Nakano Y, Baldansuren A, Matsushita S, Lin MT, Gennis RB, Hasegawa K, Kumasaka T, Dikanov SA. Dissection of hydrogen bond interaction network around an iron-sulfur cluster by site-specific isotope labeling of hyperthermophilic archaeal Rieske-type ferredoxin. <em><strong>J Am Chem Soc.<\/strong><\/em> 2012 Dec 5;134(48):19731-8. doi: 10.1021\/ja308049u. (Co-corresponding author)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>8. Lin MT, Sperling LJ, Frericks Schmidt HL, Tang M, Samoilova RI, Kumasaka T, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,\u00a0Dikanov SA, Rienstra CM, Gennis RB. A rapid and robust method for selective isotope labeling of proteins. <em><strong>Methods.<\/strong><\/em> 2011 Dec;55(4):370-8. doi: 10.1016\/j.ymeth.2011.08.019.<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>9. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>,\u00a0Kappl R, Bracic G, Shimizu N, Ohmori D, Kumasaka T. ISC-like [2Fe-2S] ferredoxin (FdxB) dimer from Pseudomonas putida JCM 20004: structural and electron-nuclear double resonance characterization. <em><strong>J Biol Inorg Chem.<\/strong><\/em> 2011 Aug;16(6):923-35. doi: 10.1007\/s00775-011-0793-8. (Co-corresponding author)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>10. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>.\u00a0Iron-sulfur world in aerobic and hyperthermoacidophilic archaea Sulfolobus. <em><strong>Archaea.<\/strong><\/em> 2010 Sep 19;2010:842639. doi: 10.1155\/2010\/842639. (Corresponding author)<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>11. Kounosu A, Hasegawa K, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of hyperthermophilic archaeal Rieske-type ferredoxin (ARF) from Sulfolobus solfataricus P1. <em><strong>Acta Crystallogr Sect F Struct Biol Cryst Commun<\/strong><\/em>. 2010 Jul 1;66(Pt 7):842-5. doi: 10.1107\/S1744309110019263. Epub 2010 Jun 24. PMID: 20606288; PMCID: PMC2898476.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>12. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Samoilova RI, Kounosu A, Ohmori D, Dikanov SA. Continuous-wave and pulsed EPR characterization of the [2Fe-2S](Cys)3(His)1 cluster in rat MitoNEET. <em><strong>J Am Chem Soc.<\/strong><\/em> 2009 Sep 30;131(38):13659-67. doi: 10.1021\/ja903228w. PMID: 19736979; PMCID: PMC2756718.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>13. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Samoilova RI, Kounosu A, Dikanov SA. Two-dimensional pulsed electron spin resonance characterization of 15N-labeled archaeal Rieske-type ferredoxin. <em><strong>FEBS Lett.<\/strong><\/em> 2009 Nov 3;583(21):3467-72. doi: 10.1016\/j.febslet.2009.09.050. Epub 2009 Oct 3. PMID: 19804777; PMCID: PMC2783746.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>14. Kounosu A, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Baba S, Hayashi-Iwasaki Y, Oshima T, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of the prototypal homologue of mitoNEET (Tth-NEET0026) from the extreme thermophile Thermus thermophilus HB8. <em><strong>Acta Crystallogr Sect F Struct Biol Cryst Commun<\/strong><\/em>. 2008 Dec 1;64(Pt 12):1146-8. doi: 10.1107\/S1744309108035975. Epub 2008 Nov 28. PMID: 19052371; PMCID: PMC2593688.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>15. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Ohmori D, Shimizu N, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of the ISC-like [2Fe-2S] ferredoxin (FdxB) from Pseudomonas putida JCM 20004. <em><strong>Acta Crystallogr Sect F Struct Biol Cryst Commun.<\/strong><\/em> 2007 Dec 1;63(Pt 12):1014-6. doi: 10.1107\/S1744309107045757. Epub 2007 Nov 21. PMID: 18084081; PMCID: PMC2344098.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>16. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A, Ohmori D, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of a hyperthermophilic Rieske protein variant (SDX-triple) with an engineered rubredoxin-like mononuclear iron site. A<em><strong>cta Crystallogr Sect F Struct Biol Cryst Commun<\/strong><\/em>. 2006 Oct 1;62(Pt 10):993-5. doi: 10.1107\/S1744309106034476. Epub 2006 Sep 30. PMID: 17012793; PMCID: PMC2225183.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>17. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A, Kolling DR, Lhee S, Crofts AR, Dikanov SA, Uchiyama T, Kumasaka T, Ishikawa H, Kono M, Imai T, Urushiyama A. Resonance Raman characterization of archaeal and bacterial Rieske protein variants with modified hydrogen bond network around the [2Fe-2S] center. <em><strong>Protein Sci<\/strong><\/em>. 2006 Aug;15(8):2019-24. doi: 10.1110\/ps.052035406. PMID: 16877714; PMCID: PMC2242589.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>18. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A, Samoilova RI, Dikanov SA. 15N HYSCORE characterization of the fully deprotonated, reduced form of the archaeal Rieske [2Fe-2S] center. <em><strong>J Am Chem Soc<\/strong><\/em>. 2006 Feb 22;128(7):2170-1. doi: 10.1021\/ja0562393. PMID: 16478144.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>19. <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kounosu A, Tao Y, Li Z, Shokes JE, Cosper NJ, Imai T, Urushiyama A, Scott RA. Rational design of a mononuclear metal site into the archaeal Rieske-type protein scaffold. <em><strong>J Biol Chem<\/strong><\/em>. 2005 Mar 11;280(10):9129-34. doi: 10.1074\/jbc.M414051200. Epub 2005 Jan 4. PMID: 15632131.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\"><br \/>20. Uchiyama T, Kounosu A, Sato T, Tanaka N, <span style=\"text-decoration: underline;\"><strong>Iwasaki T<\/strong><\/span>, Kumasaka T. Crystallization and preliminary X-ray diffraction studies of the hyperthermophilic archaeal sulredoxin having the unique Rieske [2Fe-2S] cluster environment. <em><strong>Acta Crystallogr D Biol Crystallogr.<\/strong><\/em> 2004 Aug;60(Pt 8):1487-9. doi: 10.1107\/S0907444904014295. Epub 2004 Jul 21. PMID: 15272185.<span>(Co-corresponding author)<\/span><\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\">\u00a0<\/span><\/span><\/p>\r\n<p><span color=\"#000000\" style=\"color: #000000;\"><span style=\"font-size: 13.3333px;\">\u00a0<\/span><\/span><\/p>\r\n<h3 class=\"c-ttl\">\u8b1b\u5e2b\u3000\u65e9\u5ddd \u6e05\u96c4<\/h3>\r\n<p><span style=\"color: #000000;\">1. Honda A, Koike H, Dohi T, Toyohara E, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Tobe K, Manabe I, Ogawa R, Oishi Y. CD206+ macrophages facilitate wound healing through interactions with Gpnmbhi fibroblasts. <em><strong>EMBO Rep<\/strong><\/em>. 2025 Jun 10. doi: 10.1038\/s44319-025-00496-4.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">2. Narai-Kanayama A*, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<sup>*<\/sup><\/strong><\/span>, Yoshino T, Honda F, Matsuda H, Oishi Y. Differential effects of theasinensins and epigallocatechin-3-O-gallate on phospholipid bilayer structure and liposomal aggregation. <em><strong>Biochim Biophys Acta Biomembr<\/strong><\/em>. 2024 Jun;1866(5):184312. doi: 10.1016\/j.bbamem.2024.184312. (*: equal contribution)<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">3. Kato M, Yamaguchi M, Ooka A, Takahashi R, Suzuki T, Onoda K, Yoshikawa Y, Tsunematsu Y, Sato M, Yoshioka Y, Igarashi M, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Shoji K, Shoji Y, Ishikawa T, Watanabe K, Miyoshi N. Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice. <em><strong>Sci Rep<\/strong><\/em>. 2023 Jun 1;13(1):8924. doi: 10.1038\/s41598-023-36091-7.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">4. Cheng Y, Manabe I, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Endo Y, Oishi Y. Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages. <strong><em>Front Immunol<\/em><\/strong>. 2023 Jan 27;14:1009973. doi: 10.3389\/fimmu.2023.1009973.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">5. <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko TV, Orekhov AN, Yui N, Manabe I, Oishi Y. Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling. <em><strong>JCI Insight<\/strong><\/em>. 2022 Nov 22;7(22):e138539. doi: 10.1172\/jci.insight.138539.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">6. Nakagawa A*, <span style=\"text-decoration: underline;\"><strong>Hayakawsa S<sup>*<\/sup><\/strong><\/span>, Cheng Y, Honda A, Yuzawa R, Ogawa R, Oishi Y. Cyclic stretch regulates immune responses via tank-binding kinase 1 expression in macrophages. <em><strong>FEBS Open Bio<\/strong><\/em>. 2023 Jan;13(1):185-194. doi: 10.1002\/2211-5463.13526. (*: equal contribution, Co-corresponding author)<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">7. <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Ohishi T, Oishi Y, Isemura M, Miyoshi N. Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol. <em><strong>Antioxidants<\/strong><\/em> (Basel). 2022 Nov 28;11(12):2352. doi: 10.3390\/antiox11122352.\u00a0<span>(Co-corresponding author)<\/span><\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">8. Yamaguchi F*, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<sup>*<\/sup><\/strong><\/span>, Kawashima S, Asakura T, Oishi Y. Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGF binding protein. <em><strong>Int J Oncol<\/strong><\/em>. 2022 Jul;61(1):80. doi: 10.3892\/ijo.2022.5370. (*: equal contribution)<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">9. Ohishi T, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Miyoshi N. Involvement of microRNA modifications in anticancer effects of major polyphenols from green tea, coffee, wine, and curry. <em><strong>Crit Rev Food Sci Nutr<\/strong><\/em>. 2023;63(24):7148-7179. doi: 10.1080\/10408398.2022.2038540.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">10. <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Ohishi T, Miyoshi N, Oishi Y, Nakamura Y, Isemura M. Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid. <em><strong>Molecules<\/strong><\/em>. 2020 Oct 5;25(19):4553. doi: 10.3390\/molecules25194553. (#: Corresponding author)<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">11. Saeki K, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Nakano S, Ito S, Oishi Y, Suzuki Y, Isemura M. In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea. <em><strong>Molecules<\/strong><\/em>. 2018 May 28;23(6):1295. doi: 10.3390\/molecules23061295.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">12. Yamada T, Horimoto H, Kameyama T, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Yamato H, Dazai M, Takada A, Kida H, Bott D, Zhou AC, Hutin D, Watts TH, Asaka M, Matthews J, Takaoka A. Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense. <em><strong>Nat Immunol<\/strong><\/em>. 2016 Jun;17(6):687-94. doi: 10.1038\/ni.3422.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">13. <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Saito K, Miyoshi N, Ohishi T, Oishi Y, Miyoshi M, Nakamura Y. Anti-Cancer Effects of Green Tea by Either Anti- or Pro- Oxidative Mechanisms. <em><strong>Asian Pac J Cancer Prev<\/strong><\/em>. 2016;17(4):1649-54. doi: 10.7314\/apjcp.2016.17.4.1649. (<sup>#<\/sup>: Corresponding author)<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">14. Kawata K, Iwai A, Muramatsu D, Aoki S, Uchiyama H, Okabe M, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Takaoka A, Miyazaki T. Stimulation of macrophages with the \u03b2-glucan produced by aureobasidium pullulans promotes the secretion of tumor necrosis factor-related apoptosis inducing ligand (TRAIL). <em><strong>PLoS<\/strong> <strong>One<\/strong><\/em>. 2015 Apr 13;10(4):e0124809. doi: 10.1371\/journal.pone.0124809.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">15. Tabuchi M*, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<sup>*<\/sup><\/strong><\/span>, Honda E, Ooshima K, Itoh T, Yoshida K, Park AM, Higashino H, Isemura M, Munakata H. Epigallocatechin-3-gallate suppresses transforming growth factor-beta signaling by interacting with the transforming growth factor-beta type II receptor. <em><strong>World J Exp Med<\/strong><\/em> 2013; 3(4): 100-107 doi: 10.5493\/wjem.v3.i4.100. (*: equal contribution)<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">16. Park AM, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Honda E, Mine Y, Yoshida K, Munakata H. Conditioned media from lung cancer cell line A549 and PC9 inactivate pulmonary fibroblasts by regulating protein phosphorylation. <em><strong>Arch Biochem Biophys<\/strong><\/em>. 2012 Feb 15;518(2):133-41. doi: 10.1016\/j.abb.2011.12.012.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">17. <span style=\"text-decoration: underline;\"><strong>Hayakawa S<sup>*<\/sup><\/strong><\/span>, Shiratori S*, Yamato H<sup>*<\/sup>, Kameyama T, Kitatsuji C, Kashigi F, Goto S, Kameoka S, Fujikura D, Yamada T, Mizutani T, Kazumata M, Sato M, Tanaka J, Asaka M, Ohba Y, Miyazaki T, Imamura M, Takaoka A. ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. <em><strong>Nat Immunol<\/strong><\/em>. 2011 Jan;12(1):37-44. doi: 10.1038\/ni.1963. (*: equal contribution)<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">18. Sato M, Amemiya K, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Munakata H. Subcellular localization of human heparanase and its alternative splice variant in COS-7 cells. <em><strong>Cell Biochem Funct<\/strong><\/em>. 2008 Aug;26(6):676-83. doi: 10.1002\/cbf.1492.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">19. Isogai N, Nakagawa Y, Suzuki K, Yamada R, Asamura S, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Munakata H. Cytokine-rich autologous serum system for cartilaginous tissue engineering. <em><strong>Ann Plast Surg<\/strong><\/em>. 2008 Jun;60(6):703-9. doi: 10.1097\/SAP.0b013e31814b2cb5.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">20. Hagiwara S, Kudo M, Nakatani T, Sakaguchi Y, Nagashima M, Fukuta N, Kimura M, <span style=\"text-decoration: underline;\"><strong>Hayakawa S<\/strong><\/span>, Munakata H. Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53. <em><strong>Br J Cancer<\/strong>.<\/em> 2007 Dec 3;97(11):1532-7. doi: 10.1038\/sj.bjc.6604058. Epub 2007 Oct 30.<\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">\u52a9\u6559\u3000\u8349\u91ce \u8f1d\u7537<\/h3>\r\n<p><span style=\"color: #000000;\">1. Sato N, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Nagata K, Okamoto K<sup>#<\/sup>. A non-purine inhibitor of xanthine oxidoreductase mitigates adenosine triphosphate degradation under hypoxic conditions in mouse brain. Brain Res. 2025 Feb 15;1849:149444. doi: 10.1016\/j.brainres.2025.149444.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">2. <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Nishino T, Okamoto K, Hille R, Nishino T. The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells. <em><strong>Redox Biol<\/strong><\/em>. 2023 Feb;59:102573. doi: 10.1016\/j.redox.2022.102573.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">3. Nasi S, Castelblanco M, Chobaz V, Ehirchiou D, So A, Bernabei I, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Nishino T, Okamoto K, Busso N. Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage. <em><strong>Front Cell Dev Biol<\/strong><\/em>. 2021 Feb 9;9:612440. doi: 10.3389\/fcell.2021.612440.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">4. <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Ehirchiou D, Matsumura T, Chobaz V, Nasi S, Castelblanco M, So A, Lavanchy C, Acha-Orbea H, Nishino T, Okamoto K#, Busso N. Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth. <em><strong>Nat Commun<\/strong><\/em>. 2019 Oct 28;10(1):4904. doi: 10.1038\/s41467-019-12565-z.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">5. Kato S, Kato M, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Nishino T. New Strategy That Delays Progression of Amyotrophic Lateral Sclerosis in G1H-G93A Transgenic Mice: Oral Administration of Xanthine Oxidoreductase Inhibitors That Are Not Substrates for the Purine Salvage Pathway. <em><strong>J Neuropathol Exp Neurol<\/strong><\/em>. 2016 Dec 1;75(12):1124-1144. doi: 10.1093\/jnen\/nlw088.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">6. Yamaguchi M, Okamoto K, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Matsuda Y, Suzuki G, Fuse A, Yokota H. The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL\/6 Mice. <em><strong>PLoS One<\/strong><\/em>. 2015 Jul 31;10(7):e0133980. doi: 10.1371\/journal.pone.0133980.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">7. Suzuki G, Okamoto K, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Matsuda Y, Fuse A, Yokota H. Evaluation of neuronal protective effects of xanthine oxidoreductase inhibitors on severe whole-brain ischemia in mouse model and analysis of xanthine oxidoreductase activity in the mouse brain. <em><strong>Neurol Med Chir<\/strong><\/em> (Tokyo). 2015;55(1):77-85. doi: 10.2176\/nmc.oa.2013-0307.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">8. Matsuda Y, Suzuki G, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Kawamoto Y, Yoshimura H, Fuse A, Yokota H, Naito Z, Ishiwata T. Phosphorylation of Thr(1495) of nestin in a mouse model of cerebral ischemia and reperfusion damage. <em><strong>Pathol Int<\/strong><\/em>. 2013 Sep;63(9):448-56. doi: 10.1111\/pin.12092.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">9. Kiran MD, Prakash JS, Annapoorni S, Dube S, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Okuyama H, Murata N, Shivaji S. Psychrophilic Pseudomonas syringae requires trans-monounsaturated fatty acid for growth at higher temperature. <em><strong>Extremophiles<\/strong><\/em>. 2004 Oct;8(5):401-10. doi: 10.1007\/s00792-004-0401-8.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">10. Yumoto I, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Shingyo T, Nodasaka Y, Matsuyama H, Okuyama H. Assignment of Pseudomonas sp. strain E-3 to Pseudomonas psychrophila sp. nov., a new facultatively psychrophilic bacterium. <em><strong>Extremophiles<\/strong><\/em>. 2001 Oct;5(5):343-9. doi: 10.1007\/s007920100199.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">11. Okuyama H, Ueno A, Enari D, Morita N, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>. Purification and characterization of 9-hexadecenoic acid cis-trans isomerase from Pseudomonas sp. strain E-3. <em><strong>Arch Microbiol.<\/strong><\/em> 1998 Jan;169(1):29-35. doi: 10.1007\/s002030050537.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">12. Uchida A, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Mogi T, Anraku Y, Sone N. Expression of the Escherichia coli bo-type ubiquinol oxidase with a chimeric subunit II having the CuA-cytochrome c domain from the thermophilic Bacillus caa3-type cytochrome c oxidase. <em><strong>J Biochem<\/strong><\/em>. 1997 Nov;122(5):1004-9. doi: 10.1093\/oxfordjournals.jbchem.a021839.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">13. <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Kuge S, Sakamoto J, Noguchi S, Sone N. Nucleotide and amino acid sequences for cytochrome caa3-type oxidase of Bacillus stearothermophilus K1041 and non-Michaelis-type kinetics with cytochrome c. <em><strong>Biochim Biophys Acta<\/strong><\/em>. 1996 Feb 15;1273(2):129-38. doi: 10.1016\/0005-2728(95)00126-3.<\/span><br \/><br \/><span style=\"color: #000000;\"><strong>\u7dcf\u8aac\uff08\u82f1\u6587\uff09<\/strong><\/span><br \/><span style=\"color: #000000;\">14. <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Okamoto K. Molecular mechanism and physiological significance of dehydrogenase\/oxidase conversion of mammalian xanthine oxidoreductase. <em><strong>Gout and Uric &amp; Nucleic Acids<\/strong><\/em> 2024;48(1):1-10. doi: https:\/\/doi.org\/10.14867\/gnamtsunyo.48.1_1<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">15. Okamoto K, <span style=\"text-decoration: underline;\"><strong>Kusano T<\/strong><\/span>, Nishino T. Chemical nature and reaction mechanisms of the molybdenum cofactor of xanthine oxidoreductase. <em><strong>Curr Pharm Des<\/strong><\/em>. 2013;19(14):2606-14. doi: 10.2174\/1381612811319140010.<\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<h3 class=\"c-ttl\">\u52a9\u6559\u3000\u7247\u5c71 \u6620<\/h3>\r\n<p><span style=\"color: #000000;\">1. Sugita Y, Kuwabara Y,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,\u00a0Matsuda S, Manabe I, Suzuki S, Oishi Y. Characteristic impairment of progesterone response in cultured cervical fibroblasts obtained from patients with refractory cervical insufficiency. <em><strong>Sci Rep<\/strong><\/em>. 2023 Jul 20;13(1): doi:10.1038\/s41598-023-37732-7<br \/><\/span><\/p>\r\n<p><span style=\"color: #000000;\">\u00a0<\/span><\/p>\r\n<p><span style=\"color: #000000;\">2. Ishiguro A,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,\u00a0Ishihama A. Different recognition modes of G-quadruplex RNA between two ALS\/FTLD-linked proteins TDP-43 and FUS. <em><strong>FEBS Lett<\/strong><\/em>. 2021 Feb;595(3):310\u2013323. doi:10.1002\/1873-3468.14013<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>3. Kuwabara Y, Ono S,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,\u00a0Kurihara S, Oishi Y, Takeshita T. Plasma and follicular fluid osteopontin levels during ovarian cycle and their correlation with follicular fluid vascular endothelial growth factor levels. <em><strong>Sci Rep<\/strong><\/em>. 2021 Jan 15;11:286. doi:10.1038\/s41598-020-79453-1<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>4. Tani T,\u00a0Okamoto K, Fujiwara M,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,\u00a0Tsuruoka S. Metabolomics analysis elucidates unique influences on purine\/pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury. <em><strong>Mol Med<\/strong><\/em>. 2019 Aug 22;25(1):40. doi:10.1186\/s10020-019-0109-y.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>5. Kuwabara Y,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A,<\/strong><\/span>\u00a0Kurihara S, Orimo H, Takeshita T. Immunoproteomic identification of anti-C9 autoimmune antibody in patients with seronegative obstetric antiphospholipid syndrome. <em><strong>PLoS One<\/strong><\/em>. 2018 Jun 12;13(6):e0198472. doi:10.1371\/journal.pone.0198472.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>6. Aoki M, Kang D,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,\u00a0Kuwahara N. Nagasaka S. Endo Y. Terasaki M. Kunugi S. Terasaki Y. Shimizu A. Optimal conditions and the advantages of using laser microdissection and liquid chromatography tandem mass spectrometry for diagnosing renal amyloidosis. <em><strong>Clin Exp Nephrol<\/strong><\/em>. 2018 Jan 25. doi:10.1007\/s10157-018-1533-y.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>7. Kuwabara Y,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A,<\/strong><\/span>\u00a0Kurihara S, Ito M, Yonezawa M, Ouchi N, Kurashina R, Ichikawa T, Sawa R, Nakai A, Orimo H, Takeshita T. Diversity of progesterone action on lipopolysaccharide-induced expression changes in cultured human cervical fibroblasts according to inflammation and treatment timing. <em><strong>Am J Reprod Immunol<\/strong><\/em>. 2017 Nov;78(5): doi:10.1111\/aji.12731<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>8. Nakayama A,\u00a0Kubota R, Sakatsume M, Suzuki H,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A,<\/strong><\/span>\u00a0Kanamori K, Shiba K, Iijima S. Cellulose acetate membrane electrophoresis-based urinary proteomics for the identification of characteristic proteins. <em><strong>J Clin Lab Anal<\/strong><\/em>. 2016 Sep;30(5):359\u2013367. doi:10.1002\/jcla.21863<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>9. Kuwabara Y,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>. Tomiyama R, Piao H, Kurihara S, Ono S, Mine K. Akira S, Orimo H, Takeshita T. Gonadotropin regulation and role of ovarian osteopontin in the periovulatory period. <em><strong>J Endocrinol<\/strong><\/em>. 2015 Jul;224(1):49\u201359. doi:10.1530\/JOE-14-0203.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>10. Okudela K,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>. Woo T, Mitsui H, Suzuki T, Tateishi Y, Umeda S, Tajiri M, Masuda M, Nagahara N, Kitamura H, Ohashi K. Proteome analysis for downstream targets of oncogenic KRAS \u2013 the potential participation of CLIC4 in carcinogenesis in the lung. <em><strong>PLoS One<\/strong><\/em>. 2014 Feb 5;9(2):e87193. doi:10.1371\/journal.pone.0087193.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>11. Kurata T,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,\u00a0Hiramatsu M, Kiguchi Y, Takeuchi M, Watanabe T, Ogasawara H. Ishihama A, Yamamoto K. Identification of the set of genes, including nonannotated morA, under the direct control of ModE in Escherichia coli. <em><strong>J Bacteriol.<\/strong><\/em> 2013 Oct;195(19):4496\u20134505. doi:10.1128\/jb.00304-13<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>12. Hori C, Igarashi K,\u00a0<span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>,\u00a0Samejima M. Effects of xylan and starch on secretome of the basidiomycete Phanerochaete chrysosporium grown on cellulose. <em><strong>FEMS Microbiol Lett<\/strong><\/em>. 2011;321(1):14-23. doi:10.1111\/j.1574-6968.2011.02307.x.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>13. Luo SS, Ishibashi O, Ishikawa G, Ishikawa T, <span style=\"text-decoration: underline;\"><strong>Katayama A,<\/strong><\/span> Mishima T, Takizawa T. Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes. <em><strong>Biol Reprod<\/strong><\/em>. 2009 Oct;81(4):717\u2013729. doi:10.1095\/biolreprod.108.075481<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>14. Mine K, <span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>, Matsumura T, Nishino T, Kuwabara Y, Ishikawa G, Murata T, Sawa R, Otsubo Y, Shin S, Takeshita T. Proteome analysis of human placentae: pre-eclampsia versus normal pregnancy. <em><strong>Placenta<\/strong><\/em>. 2007 Jul;28(7):676\u2013687. doi:10.1016\/j.placenta.2006.10.005.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>15. Nagahara N, <span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>. Post-translational regulation of mercaptopyruvate sulfurtransferase via a low redox potential cysteine-sulfenate in the maintenance of redox homeostasis. <em><strong>J Biol Chem<\/strong><\/em>. 2005 Nov 25;280(47):34569\u201334576. doi:10.1074\/jbc.M505643200.<br \/><\/span><\/p>\r\n<p><span style=\"color: #000000;\">\u00a0<\/span><\/p>\r\n<p><span style=\"color: #000000;\">16. Kajisa T, Yoshida M, Igarashi K, <span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>, Nishino T, Samejima M. Characterization and molecular cloning of cellobiose dehydrogenase from the brown-rot fungus Coniophora puteana. <em><strong>J Biosci Bioeng<\/strong><\/em>. 2004 Jul;98(1):57\u201363. doi.org\/10.1016\/S1389-1723(04)70242-X<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>17. <span style=\"text-decoration: underline;\"><strong>Katayama A,<\/strong><\/span> Tsujii A, Wada A, Nishino T, Ishihama A<sup>.<\/sup> Systematic search for zinc-binding proteins in Escherichia coli. <em><strong>Eur J Biochem<\/strong><\/em>. 2002 May;269(10):2403\u20132413. doi:10.1046\/j.1432-1033.2002.02900.x.<\/span><\/p>\r\n<p><span style=\"color: #000000;\"><br \/>18. <span style=\"text-decoration: underline;\"><strong>Katayama A<\/strong><\/span>, Fujita N, Ishihama A. Mapping of subunit-subunit contact surfaces on the \u03b2\u2032subunit of Escherichia coli RNA polymerase. <em><strong>J Biol Chem<\/strong><\/em>. 2000 Feb 4;275(5):3583\u20133592. doi:10.1074\/jbc.275.5.3583.<br \/><\/span><\/p>\r\n<p><span style=\"color: #000000;\">\u00a0<\/span><\/p>\r\n<h3 class=\"c-ttl\">\u52a9\u6559\u3000\u677e\u6751 \u667a\u88d5<\/h3>\r\n<p><span style=\"color: #000000;\">1. Bae SH<sup>*<\/sup>, Ikezono T<sup>*<\/sup>, Park HR, Kim H, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saito S, Maeda Y, Matsuda H, Jung J. Secretion of cochlin-tomoprotein (LCCL) in the middle ear following acute tympanic injury: implications for perilymph fistula diagnosis. <em><strong>Front Neurol<\/strong><\/em>. 2025 Apr 2; 16:1527311. doi: 10.3389\/fneur.2025.1527311.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">2. Sasaki A<sup>*<\/sup>, Ikezono T<sup>*<\/sup>, Matsuda H, Araki R, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saitoh S, Wasano K, Matsubara A. Prevalence of perilymphatic fistula in patients with sudden-onset sensorineural hearing loss as diagnosed by Cochlin-tomoprotein (CTP) biomarker detection: its association with age, hearing severity, and treatment outcomes. <em><strong>Eur Arch Otorhinolaryngol<\/strong><\/em>. 2024 May;281(5):2373-2381. doi: 10.1007\/s00405-023-08368-0.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">3. Noda S, Yamada A, Asawa Y, Nakamura H, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Orimo H, Goseki-Sone M. Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene. <em><strong>J Nutr Sci Vitaminol<\/strong><\/em> (Tokyo). 2022;68(4):284-293. doi: 10.3177\/jnsv.68.284.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">4. Matsuda H, Tanzawa Y, Sekine T, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saito S, Shindo S, Usami SI, Kase Y, Itoh A, Ikezono T. Congenital Membranous Stapes Footplate Producing Episodic Pressure-Induced Perilymphatic Fistula Symptoms. <em><strong>Front Neurol<\/strong><\/em>. 2020 Nov 10; 11:585747. doi: 10.3389\/fneur.2020.585747.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">5. Kusano T, Ehirchiou D, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Chobaz V, Nasi S, Castelblanco M, So A, Lavanchy C, Acha-Orbea H, Nishino T, Okamoto K, Busso N. Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth. <em><strong>Nat Commun<\/strong><\/em>. 2019 Oct 28;10(1):4904. doi: 10.1038\/s41467-019-12565-z.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">6. Uday S, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saraff V, Saito S, Orimo H, H\u00f6gler W. Tissue non- specific alkaline phosphatase activity and mineralization capacity of bi-allelic mutations from severe perinatal and asymptomatic hypophosphatasia phenotypes: Results from an in vitro mutagenesis model. <em><strong>Bone<\/strong><\/em>. 2019 Oct; 127:9-16. doi: 10.1016\/j.bone.2019.05.031.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">7. Ikezono T, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Matsuda H, Shikaze S, Saitoh S, Shindo S, Hasegawa S, Oh SH, Hagiwara Y, Ogawa Y, Ogawa H, Sato H, Tono T, Araki R, Maeda Y, Usami SI, Kase Y. The diagnostic performance of a novel ELISA for human CTP (Cochlin-tomoprotein) to detect perilymph leakage. <em><strong>PLoS One<\/strong><\/em>. 2018 Jan 29;13(1):e0191498. doi: 10.1371\/journal.pone.0191498.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">8. Sekine K, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span><strong>,<\/strong> Takizawa T, Kimura Y, Saito S, Shiiba K, Shindo S, Okubo K, Ikezono T. Expression Profiling of MicroRNAs in the Inner Ear of Elderly People by Real-Time PCR Quantification. <em><strong>Audiol Neurootol<\/strong><\/em>. 2017;22(3):135-145. doi: 10.1159\/000479724.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">9. Matsuda H, Sakamoto K, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saito S, Shindo S, Fukushima K, Nishio SY, Kitoh R, Shibasaki O, Ito A, Araki R, Usami SI, Suzuki M, Ogawa K, Hasegawa T, Hagiwara Y, Kase Y, Ikezono T. A nationwide multicenter study of the Cochlin tomo-protein detection test: clinical characteristics of perilymphatic fistula cases. <em><strong>Acta Otolaryngol<\/strong><\/em>. 2017;137(sup565): S53-S59. doi: 10.1080\/00016489.2017.1300940.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">10. <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Saito S, Orimo H. Immunofluorescence Labeling of a Mutant of Tissue Non-Specific Alkaline Phosphatase Lacking the Glysosylphosphatidylinositol Anchor. <em><strong>J Nippon Med Sch<\/strong><\/em>. 2016;83(4):140-1. doi: 10.1272\/jnms.83.140.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">11. Nishino T, Okamoto K, Kawaguchi Y, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Eger BT, Pai EF, Nishino T. The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase. <em><strong>FEBS J<\/strong><\/em>. 2015 Aug;282(16):3075-90. doi: 10.1111\/febs.13277.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">12. Shiiba K, Shindo S, Ikezono T, Sekine K, <span style=\"text-decoration: underline;\"><strong>Matsumura T,<\/strong><\/span> Sekiguchi S, Yagi T, Okubo K. Cochlin expression in the rat perilymph during postnatal development. <em><strong>Acta Otolaryngol<\/strong><\/em>. 2012 Nov;132(11):1134-9. doi: 10.3109\/00016489.2012.687456.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">13. Li L, Ikezono T, Sekine K, Shindo S, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Pawankar R, Ichimiya I, Yagi T. Molecular cloning of the Coch gene of guinea pig inner ear and its expression analysis in cultured fibrocytes of the spiral ligament. <em><strong>Acta Otolaryngol<\/strong><\/em>. 2010 Aug;130(8):868-80. doi: 10.3109\/00016480903493766.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">14.\u00a0Nagahara N, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Okamoto R, Kajihara Y. Protein cysteine modifications: (2) reactivity specificity and topics of medicinal chemistry and protein engineering. <em><strong>Curr Med Chem<\/strong><\/em>. 2009;16(34):4490-501. doi: 10.2174\/092986709789760643.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">15. Sekine K, Ikezono T, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Shindo S, Watanabe A, Li L, Pawankar R, Nishino T, Yagi T. Expression of cochlin mRNA splice variants in the inner ear. <em><strong>Audiol Neurootol<\/strong><\/em>. 2010;15(2):88-96. doi: 10.1159\/000231634.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">16. <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Okamoto K, Iwahara SI, Hori H, Takahashi Y, Nishino T, Abe Y. Dimer-oligomer interconversion of wild-type and mutant rat 2-Cys peroxiredoxin: disulfide formation at dimer-dimer interfaces is not essential for decamerization. <em><strong>J Biol Chem<\/strong><\/em>. 2008 Jan 4;283(1):284-293. doi: 10.1074\/jbc.M705753200.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">17. Yamaguchi Y, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Ichida K, Okamoto K, Nishino T. Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate. <em><strong>J Biochem<\/strong><\/em>. 2007 Apr;141(4):513-24. doi: 10.1093\/jb\/mvm053.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">18. Asai R, Nishino T, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Okamoto K, Igarashi K, Pai EF, Nishino T. Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase. J Biochem. 2007 Apr;141(4):525-34. doi: 10.1093\/jb\/mvm054. <em><strong>Erratum in: J Biochem<\/strong><\/em>. 2008 Nov;144(5):691.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">19. Mine K, Katayama A, <span style=\"text-decoration: underline;\"><strong>Matsumura T<\/strong><\/span>, Nishino T, Kuwabara Y, Ishikawa G, Murata T, Sawa R, Otsubo Y, Shin S, Takeshita T. Proteome analysis of human placentae: pre-eclampsia versus normal pregnancy. <em><strong>Placenta<\/strong><\/em>. 2007 Jul;28(7):676-87. doi: 10.1016\/j.placenta.2006.10.005.<\/span><\/p>\r\n<p><br \/><span style=\"color: #000000;\">20. Nagahara N, Yoshii T, Abe Y, <strong><span style=\"text-decoration: underline;\">Matsumura T<\/span><\/strong>. Thioredoxin-dependent enzymatic activation of mercaptopyruvate sulfurtransferase. An intersubunit disulfide bond serves as a redox switch for activation. <em><strong>J Biol Chem<\/strong><\/em>. 2007 Jan 19;282(3):1561-9. doi: 10.1074\/jbc.M605931200.<\/span><\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/li>\r\n<li class=\"accordion\">\r\n<div class=\"acc-header\">\u6559\u5ba4\u30e1\u30f3\u30d0\u30fc<\/div>\r\n<div class=\"acc-content\">\r\n<div>\r\n<h3 class=\"c-ttl\">\u5927\u5b66\u9662\u6559\u6388<\/h3>\r\n<p>\u4f50\u85e4\u3000\u3000\u5353<\/p>\r\n<\/div>\r\n<div class=\"u-mt-40 u-mt-sp-30\">\r\n<h3 class=\"c-ttl\">\u8b1b\u5e2b<\/h3>\r\n<p>\u5ca9\u5d0e\u3000\u4fca\u96c4<br \/>\u65e9\u5ddd\u3000\u6e05\u96c4<\/p>\r\n<\/div>\r\n<div class=\"u-mt-40 u-mt-sp-30\">\r\n<h3 class=\"c-ttl\">\u52a9\u6559<\/h3>\r\n<p>\u8349\u91ce\u3000\u8f1d\u7537<br \/>\u677e\u6751\u3000\u667a\u88d5\uff08URA\uff09<br \/>\u7247\u5c71\u3000\u3000\u6620\uff08\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u5206\u5b50\u89e3\u6790\u7814\u7a76\u5ba4\uff09<\/p>\r\n<\/div>\r\n<div class=\"u-mt-40 u-mt-sp-30\">\r\n<h3 class=\"c-ttl\">\u30c6\u30af\u30cb\u30ab\u30eb\u30fb\u30b5\u30dd\u30fc\u30c8\u30b9\u30bf\u30c3\u30d5<\/h3>\r\n<p>\u5ddd\u53e3\u3000\u88d5\u5b50<br \/>\u59cb\u95a2\u3000\u7d00\u7ae0<\/p>\r\n<\/div>\r\n<div class=\"u-mt-40 u-mt-sp-30\">\r\n<h3 class=\"c-ttl\">\u7814\u7a76\u88dc\u52a9\u54e1<\/h3>\r\n<p>\u6df1\u6fa4\u3000\u91cc\u6c99\u5b50<\/p>\r\n<\/div>\r\n<div class=\"u-mt-40 u-mt-sp-30\">\r\n<h3 class=\"c-ttl\">\u5927\u5b66\u9662\u751f<\/h3>\r\n<p>\u672c\u7530\u3000\u6893\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u5f62\u6210\u5916\u79d1\uff09 <br \/>\u6749\u91ce\u3000\u5065\u592a\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u814e\u81d3\u5185\u79d1\uff09 <br \/>\u6749\u7530\u3000\u6d0b\u4f51\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u7523\u5a66\u4eba\u79d1\uff09 <br \/>\u677e\u7530\u3000\u3000\u7e41\uff08\u65e5\u672c\u533b\u79d1\u5927\u5b66\u7523\u5a66\u4eba\u79d1\uff09<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/section>","protected":false},"excerpt":{"rendered":"\u79c1\u305f\u3061\u306e\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\uff08\u4ee3\u8b1d\u30fb\u6804\u990a\u5b66\uff09\u6559\u5ba4\uff08\u65e7\u751f\u5316\u5b66\u7b2c\u4e00\u8b1b\u5ea7\uff09\u306f\u30011936\u5e74\u306e\u5275\u7acb\u4ee5\u676580\u5e74\u4ee5\u4e0a\u306b\u4e98\u308a\u3001\u591a\u304f\u306e\u6307\u5c0e\u7684\u306a\u751f\u5316\u5b66\u8005\u3092\u8f29\u51fa\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u81e8\u5e8a\u304b\u3089\u5927\u5b66\u9662\u751f\u30fb\u7814\u7a76\u751f\u3092\u53d7\u3051\u5165\u308c\u3001\u512a\u308c\u305f\u81e8\u5e8a\u7814\u7a76 [&hellip;]","protected":false},"author":1,"featured_media":0,"parent":8,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-department.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-111","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/comments?post=111"}],"version-history":[{"count":35,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/111\/revisions"}],"predecessor-version":[{"id":5854,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/111\/revisions\/5854"}],"up":[{"embeddable":true,"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/www.nms.ac.jp\/college\/wp-json\/wp\/v2\/media?parent=111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}