{"id":179,"date":"2025-09-30T13:06:39","date_gmt":"2025-09-30T04:06:39","guid":{"rendered":"https:\/\/www.nms.ac.jp\/college\/?page_id=179"},"modified":"2026-03-06T19:09:57","modified_gmt":"2026-03-06T10:09:57","slug":"seibutsugaku","status":"publish","type":"page","link":"https:\/\/www.nms.ac.jp\/college\/department\/kisokagaku\/seibutsugaku\/","title":{"rendered":"\u751f\u7269\u5b66"},"content":{"rendered":"
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\r\n \u5352\u524d\u6559\u80b2\r\n <\/h3>
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\u7b2c2\u5b66\u5e74\u3067\u306f\u4e3b\u3068\u3057\u3066\u300c\u7d44\u7e54\u30fb\u81d3\u5668\u306e\u767a\u751f\u3001\u69cb\u9020\u3068\u6a5f\u80fd2\u300d\u3092\u62c5\u5f53\u3057\u3066\u3044\u307e\u3059\u3002\u4eba\u4f53\u767a\u751f\u306e\u57fa\u790e\u3068\u3057\u3066\u3001\u7b2c1\u5b66\u5e74\u306b\u3064\u3065\u3044\u3066\u5148\u5929\u7570\u5e38\u306b\u3064\u3044\u3066\u5b66\u3073\u3001\u518d\u751f\u533b\u5b66\u3068\u95a2\u9023\u3065\u3051\u3066\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3057\u3066\u3044\u307e\u3059\u3002
\u3053\u306e\u4ed6\u3001\u7b2c3\u5b66\u5e74\u306e\u300c\u79d1\u5b66\u7684\u63a2\u7a763\u300d\u3067\u306f\u3001\u5206\u5b50\u751f\u7269\u5b66\u3084\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u306a\u3069\u306e\u624b\u6cd5\u3092\u4f7f\u3063\u3066\u52d5\u7269\u5b9f\u9a13\u3092\u884c\u3044\u3001\u7814\u7a76\u306e\u9b45\u529b\u3084\u79d1\u5b66\u7684\u8003\u5bdf\u306e\u9762\u767d\u3055\u3092\u4f53\u9a13\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n

\r\n \"\u9577\u8c37\u90e8\r\n

\r\n \u6559\u6388\u3000\u9577\u8c37\u90e8\u3000\u5b5d<\/span>\r\n \r\n <\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n

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\r\n \u4e3b\u306a\u7814\u7a76\u5185\u5bb9\r\n <\/h3>\r\n

\u5f53\u6559\u5ba4\u3067\u306f\u3001\u6d88\u5316\u7ba1\u5e79\u7d30\u80de\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u5206\u5b50\u767a\u751f\u751f\u7269\u5b66\u7684\u306a\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306b\u3088\u3063\u3066\u5e79\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u3092\u5b9f\u9a13\u30e2\u30c7\u30eb\u3068\u3057\u3001\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u3084\u30b2\u30ce\u30e0\u7de8\u96c6\u3001\u5668\u5b98\u57f9\u990a\u3001\u30ec\u30dd\u30fc\u30bf\u30fc\u30a2\u30c3\u30bb\u30a4\u3001in situ hybridization chain reaction (HCR)\u3001\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u306a\u3069\u306e\u624b\u6cd5\u3092\u99c6\u4f7f\u3057\u3066\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u306e\u89e3\u660e\u3092\u9032\u3081\u3001\u6d88\u5316\u5668\u7cfb\u306e\u518d\u751f\u533b\u5b66\u306e\u767a\u5c55\u306b\u5bc4\u4e0e\u3067\u304d\u308b\u57fa\u790e\u7814\u7a76\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\r\n <\/p>\r\n <\/div>\r\n

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    \u7814\u7a76\u696d\u7e3e<\/div>\r\n
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    2024\u5e74<\/h3>\r\n

    Suzuki M, Okumura A, Chihara A, Shibata Y, Endo T, Teramoto M, Agata K, Bronner ME, Suzuki KT. Fgf10 mutant newts regenerate normal hindlimbs despite severe developmental defects. Proc Natl Acad Sci 121: 2314911121, 2024\r\n

    Hibino M, Aoki R, Ha DA, Sano H, Yamashita S, Ogasawara H, Nishio K, Kotake K, Mamun MU, Okada R, Shibata Y, Suzuki M. Ontogenetic expression of aquaporins in the kidney and urinary bladder of the Japanese tree frog, Dryophytes japonicus. Zoolog Sci 41: 124-131, 2024\r\n

    Fu L, Wang S, Liu L, Shibata Y, Okada M, Nga L, Shi Y-B. Simplifying genotyping of mutants from genome editing with a parallel qPCR-based iGenotype index. Cells 13: 247, 2024\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2023\u5e74<\/h3>\r\n

    \r\n Fujimoto K, Shibata Y, Hasebe T. Thyroid hormone-activated signaling pathways are essential for development of intestinal stem cells. J Nippon Med Sch 90: 246-52, 2023\r\n

    Hasebe T, Fujimoto K, Ishizuya-Oka A. Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the amphibian intestine during metamorphosis. Vitam Horm 122: 1-22, 2023\r\n

    Shibata Y, Okumura A., Mochii M, Suzuki KT. Protocols for transgenesis at a safe harbor site in the Xenopus laevis genome using CRISPR-Cas9. STAR Protoc 4: 102382, 2023\r\n

    Tanizaki Y, Wang S, Zhang H, Shibata Y, Shi Y-B. Liver development during Xenopus tropicalis metamorphosis is controlled by T3-activation of WNT signaling. iScience 26: 106301, 2023\r\n

    Tanizaki Y, Shibata Y, Na W, Shi Y-B. Cell cycle activation in thyroid hormone-induced apoptosis and stem cell development during Xenopus intestinal metamorphosis. Front Endocrinol 14: 1184013, 2023\r\n

    Tanizaki Y, Hongen Zhang, Shibata Y, Shi Y-B. Organ-specific effects on target binding due to knocking out thyroid hormone receptor alpha during Xenopus metamorphosis. Dev Growth Differ 65: 23-28, 2023\r\n

    Fu L, Ma E, Okada, M, Shibata Y, Shi Y-B. Competitive PCR with dual fluorescent primers enhances the specificity and reproducibility of genotyping animals generated from genome editing. Cell Biosci 13: 83, 2023\r\n

    Wang S, Shibata Y, Fu L, Tanizaki Y, Luu N, Bao L, Peng Z, Shi Y-B. Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax. Cell Biosci 13: 40, 2023\r\n

    Wang S, Shibata Y, Tanizaki Y, Zhang H, Yan W, Fu L, Shi Y-B. Comparative analysis of transcriptome profiles reveals distinct and organ-dependent genomic and nongenomic actions of thyroid hormone in Xenopus tropicalis tadpoles. Thyroid 33: 511-522, 2023\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2022\u5e74<\/h3>\r\n

    \r\n Hasebe T, Fujimoto K, Ishizuya-Oka A. Essential roles of YAP-TEAD complex in adult stem cell development during thyroid hormone-induced intestinal remodeling of Xenopus laevis. Cell Tissue Res 388: 313-29, 2022\r\n

    Tanizaki Y, Shibata Y, Hongen Zhang, Shi Y-B. Thyroid hormone receptor alpha controls the hindlimb metamorphosis by regulating cell proliferation pathways and WNT signaling in Xenopus tropicalis. Int J Mol Sci 23(3): 1223, 2022\r\n

    Shibata Y, Suzuki M, Hirose N, Takayama A, Sanbo C, Inoue T, Umesono Y, Agata K, Ueno N, Suzuki KT, Mochii M. CRISPR\/Cas9-based simple transgenesis in Xenopus laevis. Dev Biol 489: 76-83, 2022\r\n

    Tanizaki Y, Zhang H, Shibata Y, Shi Y-B. Thyroid hormone receptor alpha controls larval intestinal epithelial cell death by regulating the CDK1 pathway. Commun Biol 5: 112, 2022\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2020\u5e74<\/h3>\r\n

    \r\n Hasebe T, Fujimoto K, Ishizuya-Oka A. Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling. Sci Rep 10: 20715, 2020\r\n

    Hasebe T, Fujimoto K, Buchholz DR, Ishizuya-Oka A. Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the Xenopus metamorphosing intestine. Gen Comp Endocrinol 292: 113441, 2020\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2018\u5e74<\/h3>\r\n

    \r\n Fujimoto K, Hasebe T, Kajita M, Ishizuya-Oka A. Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis. Dev Genes Evol 228: 267-273, 2018\r\n

    Sakane Y, Iida M, Hasebe T, Fujii S, Buchholz DR, Ishizuya-Oka A, Yamamoto T, Suzuki KT. Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas. Biol Open 7 pii: bio030338, 2018\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2017\u5e74<\/h3>\r\n

    \r\n Hasebe T, Fujimoto K, Kajita M, Ishizuya-Oka A. Essential roles of thyroid hormone-regulated hyaluronan\/CD44 signaling in adult stem cell development during Xenopus laevis intestinal remodeling. Stem Cells 35: 2175-2183, 2017\r\n

    Hasebe T, Fujimoto K, Kajita M, Fu L, Shi Y-B, Ishizuya-Oka A. Thyroid hormone-induced activation of Notch signaling is required for adult intestinal stem cell development during Xenopus laevis metamorphosis. Stem Cells 35: 1028-1039, 2017\r\n

    Luu N, Fu L, Fujimoto K, Shi Y-B. Direct regulation of histidine ammonia-lyase 2 gene by thyroid hormone in the developing adult intestinal stem cells. Endocrinology 158: 1022-1033, 2017\r\n

    Choi J, Ishizuya-Oka A, Buchholz DR. Growth, development, and intestinal remodeling occurs in the absence of thyroid hormone receptor \u03b1 in tadpoles of Xenopus tropicalis. Endocrinology 158: 1623-1633, 2017\r\n

    Fu L, Das B, Matsuura K, Fujimoto K, Heimeier RA, Shi Y-B. Genome-wide identification of thyroid hormone receptor targets in the remodeling intestine during Xenopus tropicalis metamorphosis. Sci Rep 25: 6414, 2017\r\n

    Ishizuya-Oka A. How thyroid hormone regulates transformation of larval epithelial cells into adult stem cells in the amphibian intestine. Mol Cell Endocrinol 459: 98-103, 2017\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2016\u5e74<\/h3>\r\n

    \r\n Hasebe T, Fujimoto K, Kajita M, Ishizuya-Oka A. Thyroid hormone activates Wnt\/beta-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis. Cell Tissue Res 365: 309-318, 2016

    Araki Y, Tsuzuki-Wada T, Aizaki Y, Sato K, Yokota K, Fujimoto K, Kim Y, Oda H, Kurokawa R, Mimura T. Histone methylation and STAT-3 differentially regulate interleukin- 6-induced matrix metalloproteinase gene activation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheumatol 68: 1111-1123, 2016\r\n

    Kato S, Takaichi S, Ishikawa T, Asahina M, Takahashi S, Shinomura T. Identification and functional analysis of geranylgeranyl pyrophosphate synthase gene(crtE) and phytoene synthase gene(crtB) for carotenoid biosynthesis in Euglena gracilis. BMC Plant Biol 6:e4, 2016\r\n

    Nuyanzina-Boldareva E, Akimov V, Takaichi S, Gorlenko V. New strains of an aerobic anoxygenic phototrophic bacterium Porphyrobacter donghaensis isolated from a Siberian thermal spring and a weakly mineralized lake. Microbiology 85: 77-86, 2016\r\n

    Tanaka K, Iida S, Takaichi S, Mimuro M, Murakami A, Akimoto S. Excitation relaxation dynamics and energy transfer in pigment-protein complexes of a dinoflagellate, revealed by ultrafast fluorescence spectroscopy. Photosynth Res 130: 183-191, 2016\r\n

    Takaichi S, Yokoyama A, Mochimau M, Uchida H, Murakami A. Carotenogenesis diversification in phylogenetic lines of Rhodophyta. J Phycol 52: 329-338, 2016\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2015\u5e74<\/h3>\r\n

    \r\n Wen L, Hasebe T, Miller TC, Ishizuya-Oka A, Shi Y-B. A requirement for hedgehog signaling in thyroid hormone-induced postembryonic intestinal remodeling. Cell Biosci 5: 13, 2015\r\n

    Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S. Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica. J Bacterol 197: 1614-1623, 2015\r\n

    Kusama Y, Inoue S, Jimbo H, Takaichi S, Sonoike K, Hihara Y, Nishiyama Y. Zeaxanthin and echinenone protect the repair of photosystem II from inhibition by singlet oxygen in Synechocystis sp. PCC 6803. Plant Cell Physiol 56: 906-916, 2015\r\n

    Furubayashi M, Ikezumi M, Takaichi S, Maoka T, Hemmi H, Ogawa T, Saito K, Tobias A, Umeno D. A highly selective biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes. Nature Commun 6: e7534-, 2015\r\n

    Nupur P, Tanuku N, Takaichi S, Pinnaka A. Phaeobacterium nitratireducens gen. nov., sp. nov., a phototrophic gammaproteobacterium isolated from a mangrove forest sediment sample. Int J Syst Evol Microbiol 65: 2357-2364, 2015\r\n

    Takaichi S, Maoka T. Identification and spectroscopic characterization of neurosporene. Biotechnol Lett 37: 2027-2031, 2015\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2014\u5e74<\/h3>\r\n

    \r\n Ishizuya-Oka A, Kajita M, Hasebe T. Thyroid hormone-regulated Wnt5a\/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine. PLoS One 9: e107611, 2014\r\n

    Fujii J, Kodama M, Oike A, Matsuo Y, Min MS, Hasebe T, Ishizyya-Oka A, Kawakami K, Nakaura M. Involvement of androgen receptor in sex determination in an amphibian species. PLoS One 9: e93655, 2014\r\n

    Takaichi S: General methods for identification of carotenoids. Biotechnol Lett 36: 1127-1128, 2014\r\n

    Yatsunami R, Ando A, Yang Y, Takaichi S, Kohno M, Matsumura Y, Ikeda H, Fukui T, Nakasone K, Fujita N, Sekine M, Takashina T, Nakamura S. Identification of carotenoids from the extremely halophilic archaeon Haloarcula japonica. Front Microbiol: Extreme Microbiol 5: 100, 2014\r\n

    Nupur P, Srinivas TNR, Takichi S, Anil Kumar P. Rhodovulum mangrovi sp. nov., a phototrophic alphaproteobacterium isolated from a mangrove for- est sediment sample. Int J Syst Evol Microbiol 64: 3168-3173, 2014\r\n

    Tamiru M, Abe A, Yoshida K, Takagi H, Takagi H, Fujisaki K, Undan J, Rakshit S, Takaichi S, Jikumaru Y, Yokota T, Terry M, Terauchi R. The tillering phenotype of the rice plastid terminal oxidase\uff08PTOX\uff09loss-of-function mutant is associated with strigolactone deficiency. New Phytologist\u3000204: 116-131, 2014\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2013\u5e74<\/h3>\r\n

    \r\n Sun G, Heimeier RA, Fu L, Hasebe T, Das B, Ishizuya-Oka A, Shi Y-B. Expression profiling of intestinal tissues implicates tissue-specific genes and pathways essential for thyroid hormone-induced adult stem cell development. Endocrinology 154:4396-4407, 2013\r\n

    Miller TC, Sun G, Hasebe T, Fu L, Heimeier RA, Das B, Ishizuya-Oka A, Shi Y-B. Tissue-specific upregulation of MDS\/EVI gene transcripts in the intestine by thyroid hormone during Xenopus metamorphosis. PLoS One 8: e55585, 2013\r\n

    Hasebe T, Fu L, Miller TC, Zhang Y,Shi Y-B, Ishizuya-Oka A. Thyroid hormone-induced cell-cell interactions are required for the development of adult intestinal stem cells. Cell Biosci. 3: 18, 2013\r\n

    Ishizuya-Oka A, Hasebe T. Establishment of intestinal stem cell niche during amphibian metamorphosis. Curr Top Dev Biol 103: 305-327, 2013\r\n

    Kim Y, Kim S, Um J, Kim K, Choi S, Um B, Kang S, Kim J, Takaichi S, Song S, Lee C, Kim H, Kim K, Nam K, Lee S, et al. Functional implication of \u03b2-carotene hydroxylase in soybean nodulation.\u3000Plant Physiol 162: 1420-1433, 2013\r\n <\/p>\r\n <\/div>\r\n

    \r\n

    2012\u5e74\u4ee5\u524d<\/h3>\r\n

    \r\n Hasebe T, Kajita M, Fu L, Shi Y-B, Ishizuya-Oka A.Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis. Dev Dyn 241, 403-414, 2012\r\n

    Takaichi S, Murakami A, Mochimaru M, Yokoyama A. \u03b1-Carotene and its derivatives have a sole chirality in phototrophic organisms?. Acta Biochimi Polon 59: 159-161, 2012\r\n

    Takaichi S, Sasikala HC, Ramana HC, Okamura K, Hiraishi A. Carotenoids in Rhodoplanes species: variation of compositions and substrate specificity of predicted carotenogenesis enzymes. Curr Microbiol 65: 150-155, 2012\r\n

    Asao M, Takaichi S, Madigan M. Amino acid-assimilating phototrophic heliobacteria from soda lake environments: Heliorestis acidaminivorans, sp. nov. and \u2018Candidatus Heliomonas lunata\u2019. Extremophiles 16:585-595, 2012\r\n

    Takaichi S, Mochimaru M, Uchida H, Murakami A, Hirose E, Maoka T, Tsuchiya T, Mimuro M. Opposite chilarity of \u03b1-carotene in un- usual cyanobacteria with unique chlorophylls, Acaryochloris and Prochlorococcus. Plant Cell Physiol 53: 1881-1888, 2012\r\n

    Wakahama T, Lazxa-Martinez A, Taha A, Okuyama H, Yoshida, Kogame K, Awai K, Kawachi M, Moka T, Takaichi S. Structural confirmation of a unique carotenoid lactoside, P457, in Symbiodinium sp. strain NBRC 104787 isolated from sea anemone and its distribution in dinoflagellates and various marine organisms. J Phycol 48: 1392-1402, 2012\r\n

    Wakahama T, Okuyama H, Maoka T, Takaichi S. Unique carotenoid lactoside, P457, in Symbiodinium sp. of dinoflagellate. Acta Biochimi Polon 59: 155-157, 2012\r\n

    Arima H, Horiguchi N, Takaichi S, Kofuji R, Ishida K, Wada K, Sakamoto T. Molecular genetic and chemotaxonomic characterization of the terrestrial cyanobacterium Nostoc commune and its neighboring species. FEMS Microbiol Ecol 79: 34-45, 2012\r\n

    Yoshii H, Yoshii Y, Asai T, Furukawa T, Takaichi S, Fujibayashi Y. Photo-excitation of carotenoids causes cytotoxicity via singlet oxygen production. Biochem Biophys Res Commu 412: 640-645, 2012\r\n

    Hasebe T, Buchholz DR, Shi YB, Ishizuya-Oka A. Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine. Stem Cells 29: 154-161, 2011\r\n

    Motoi N, Hasebe T, Suzuki K, Ishizuya-Oka A. Spatiotemporal expression profile of no29\/nucleophosmin3 in the intestine of Xenopus laevis during metamorphosis. Cell Tissue Res 344: 445-453, 2011\r\n

    Hasebe T, Kajita M, Iwabuchi M, Ohsumi K, Ishizuya-Oka A. Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis. Dev Genes Evol 221: 199-208, 2011\r\n

    Fujiwara M, Hasebe T, Kajita M, Ishizuya-Oka A, Ghazizadeh M, Kawanami O. RCAN1 regulates vascular branching during Xenopus laevis angiogenesis. J Vasc Res 48: 104-118, 2011\r\n

    Shi Y-B, Hasebe T, Fu L, Fujimoto K, Ishizuya-Oka A. The development of the adult intestinal stem cells: Insights from studies on thyroid hormone-dependent amphibian metamorphosis. Cell Biosci 1: 30-e9, 2011\r\n

    Takaichi S, Maoka T, Sasikala C, Ramana C, Shimada K. Genus specific unusual carotenoids in purple bacteria, Phaeospirillum and Roseospira: structures and biosynthesis. Curr Microbiol 63: 75-80, 2011\r\n

    Lakshmi K, Sasikala C, Takaichi S, Ramana C. Phaeospirillum oryzae sp. nov., a spheroplast-forming, phototrophic alphaproteobacterium from a paddy soil. Int J Syst Evol Microbiol 61: 1656-1661, 2011\r\n

    Ichinomiya M, Yoshikawa S, Kamiya M, Ohki K, Takaichi S, Kuwata A. Isolation and characterization of Parmales (Heterokonta\/ Heterokontophyta\/ Stramenopiles) from the Oyashio region, Western North Pacific. J Phycol 47: 144-151, 2011\r\n

    Sun G, Hasebe T, Fujimoto K, Lu R, Fu L, Matsuda H, Kajita M, Ishizuya-Oka A, Shi Y-B. Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone- dependent metamorphosis in Xenopus laevis. PLoS One 5: e13605, 2010\r\n

    Ishizuya-Oka A, Hasebe T, Shi Y-B. Apoptosis in amphibian organs during metamorphosis. Apoptosis 15: 350-364, 2010\r\n

    Mathew S, Fu L, Hasebe T, Ishizuya-Oka A, Shi Y-B. Tissue-dependent in- duction of apoptosis by matrix metalloproteinase stromelysin-3 during amphibian metamorphosis. Birth Defects Res C Embryo Today 90: 55-66, 2010\r\n

    Fujisawa T, Narikawa R, Okamoto S, Ehira S, Yoshimura H, Suzuki I, Masuda T, Mochimaru M, Takaichi S, Awai K, Sekine M, Horikawa H, Yashio I, Omata S, Takarada H, et al. Genomic structure of an economically important cyanobacterium, Arthrospira (Spirulina) platensis NIES-39. DNA Res 17: 85-103, 2010\r\n

    Sucharita K, Shiva Kumar E, Sasikala C, Panda B, Takaichi S, Ramana C. Marichromatium fluminis sp. nov., a slightly alkaliphilic, phototrophic gammaproteobacterium isolated from river sediment. Int J Syst Evol Microbiol 60: 1103-1107, 2010\r\n

    Venkata Ramana V, Sasikala C, Takaichi S, Ramana C. Roseomonas aestuarii sp. nov., a bacteriochlorophyll-a containing alphaproteobacterium isolated from an estuarine habitat of India. Syst Appl Microbiol 33: 198- 203, 2010\r\n

    Girija K, Sasikala C, Ramana C, Sproer C, Takaichi S, Thiel V, Imhoff J. Rhodobacter johrii sp. nov., an endospore-producing cryptic species isolated from semi-arid tropical soils. Int J Syst Evol Microbiol 60: 2099-2107, 2010\r\n

    Ishizuya-Oka A, Hasebe T, Buchholz DR, Kajita M, Fu L, Shi Y-B. The origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis. FASEB J 23: 2568-2575, 2009\r\n

    Matsuda H, Paul BD, Choi CY, Hasebe T, Shi Y-B. Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamor phic rate in Xenopus laevis. Mol Cell Biol 29: 745-757, 2009\r\n

    Rankin S, Hasebe T, Zorn A, Buchholz D. Improved Cre reporter transgenic Xenopus. Dev Dyn 238: 2401-2408, 2009\r\n

    Wang Y, Mukhopadhyay D, Mathew S, Hasebe T, Heimeier R, Azuma Y, Kolli N, Shi Y-B, Wilkinson K, Dasso M. Identification and developmental expression of Xenopus laevis SUMO proteases. PLoS One 4: e8462, 2009\r\n

    Anil Kumar P, Srinivas T, Takaichi S, Maoka T, Sasikala C, Ramana C. Phaeospirillum chandramohanii sp. nov., a phototrophic alphaproteobacterium with carotenoid glycosides. Int J Syst Evol Microbiol 59: 2089-2093, 2009\r\n

    Kusaba M, Maoka T, Morita R, Takaichi S. A novel carotenoid derivative,lutein3-acetate, accumulatesinsenescentleavesofrice. Plant Cell Physiol 50: 1573- 1577, 2009\r\n

    Takaichi S, Maoka T, Akimoto N, Takasaki K, Hanada S. Carotenoids of Gemmatimonas aurantiaca (Gemmatimonadetes): identification of a novel carotenoid, deoxyoscillol 2-rhamnoside, and proposed biosynthetic pathway of oscillol 2,2 \u2019-dirhamnoside. Microbiology 156: 757-763, 2009\r\n

    Takaichi S, Maoka T, Mochimaru M. Unique carotenoids in the terrestrial cyanobacterium Nostoc commune NIES-24: 2-hydroxymyxol 2 \u2019-fucoside, nostoxanthin and canthaxanthin. Curr Microbiol 59: 413-419, 2009\r\n

    Hasebe T, Kajita M, Shi Y-B, Ishizuya-Oka A. Thyroid hormone-upregulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis. Dev Dyn 237: 3006-3015, 2008\r\n

    Ishizuya-Oka A, Hasebe T. Sonic hedgehog and bone morphogenetic protein-4 signaling pathway involved in epithelial cell renewal along the radial axis of the intestine. Digestion 77(suppl.1): 42-47, 2008\r\n

    Ishizuya-Oka A, Shi Y-B. Thyroid-hormone regulation of stem cell development during intestinal remodeling. Mol Cell Endocrinol 288: 71-78, 2008\r\n

    Takaichi S, Maoka T, Akimoto N, Carmona LM, Yamaoka Y. Carotenoids in a Corynebacterineae, Gordonia terrae AIST-1: carotenoid glucosyl mycoloyl esters. Biochem Biosci Biotechnol 72: 2615-2622, 2008\r\n

    Akimoto S, Yokono M, Higuchi M, Tomo T, Takaichi S, Murakami A, Mimuro M. Solvent effects on excitation relaxation dynamics of a keto-carotenoid, siphonaxanthin. Photochem Photobiol Sci 7: 1206-1209, 2008\r\n

    Mochimaru M, Masukawa H, Maoka T, Mohamed EH, Vermaas JW, Takaichi S. Substrate specificities and availability of fucosyltransferase and \u03b2-carotene hydroxylase for myxol 2\u2032-fucoside synthesis in Anabaena sp. strain PCC 7120 compared with Synechocystis sp. strain PCC 6803. J Bacteriol 190: 6726-6733, 2008\r\n

    Iwai M, Maoka T, Ikeuchi M, Takaichi S. 2,2\u2019-\u03b2-Hydroxylase (CrtG) is involved in carotenogenesis of both nostoxanthin and 2-hydroxymyxol 2\u2019-fucoside in Thermosynechococcus elongatus strain BP-1. Plant Cell Physiol 49: 1678-1687, 2008\r\n

    Sandmann G, Takaichi S, Fraser DP. C35- apocarotenoids in the yellow mutant Neurospora crassa YLO. Phytochemistry 69: 2886- 2890, 2008\r\n

    Makino T, Harada H, Ikenaga H, Matsuda S, Takaichi S, Shindo K, Sandmann G, Ogata T, Misawa N. Characterization of cyanobacterial carotenoid ketolase CrtW and hydroxylase CrtR by complementation analysis in Escherichia coli. Plant Cell Physiol 49: 1867-1878, 2008\r\n

    Herbert RA, Gall A, Maoka T, Cogdell RJ, Robert B, Takaichi S, Schwabe S. Phototrophic purple sulfur bacteria as heat engines in the South Andros Black Hole. Phytosynth Res 95:261-268, 2008\r\n

    Khan ST, Takaichi S, Harayama S. Paracoccus marinus sp. nov., an adonixanthin diglucoside-producing bacterium isolated from costal seawater in Tokyo Bay. Int J System Evol Microbiol 58: 383-386, 2008\r\n

    Ishizuya-Oka A, Shi Y-B. Regulation of adult intestinal epithelial Stem cell development by thyroid hormone during Xenopus laevis metamorphosis. Dev Dyn 236: 3358-3368, 2007\r\n

    Hasebe T, Kajita M, Fujimoto K, Yaoita Y, Ishizuya-Oka A. Expression profiles of the duplicated matrix metalloproteinase-9 genes suggest their different roles in apoptosis of larval intestinal epithelial cells during Xenopus laevis metamorphosis. Dev Dyn 236: 2338-2345, 2007\r\n

    Shi Y-B, Fu L, Hasebe T, Ishizuya-Oka A. Regulation of ECM remodeling and cell fate determination by matrix metalloproteinase strmoelysin-3 during thyroid hormone-dependent postembryonic development. Pharmacol & Ther 116: 391-400, 2007\r\n

    Fu L, Hasebe T, Ishizuya-Oka A, Shi Y-B. Roles of matrix metalloproteinases and ECM remodeling during thyroid hormone-dependent intestinal metamorphosis in Xenopus laevis. Organogenesis 3: 14-19, 2007\r\n

    Ishizuya-Oka A. Regeneration of the amphibian intestinal epithelium under the control of stem cell niche. Dev Growth Differ 49: 99-107, 2007\r\n

    Shindo K, Kikuta K, Suzuki A, Katsuta A, Kasai H, Misawa N, Takaichi S. (3R)-Saproxanthin, (3R,2\u2032S)-myxol, and (3R,3\u2032R)-zeaxanthin from three novel marine bacteria (Flavobacteriaceae), and their antioxidant activities. Appl Microbiol Biotechnol 74: 1350-1357, 2007\r\n

    Suzuki H, Hirano Y, Kumura Y, Takaichi S, Kobayashi M, Miki K, Wang Z-Y. Purification, characterization and crystallization of the core complex from thermophilic purple sulfur bacterium Thermochromatium tepidum. Biochim Biophys Acta 1767: 1057-1063, 2007\r\n

    Yoshida K, Yoshioka D, Inoue K, Takaichi S, Maeda I. Evaluation of colors in green mutants isolated from purple bacteria as a host for colorimetric whole-cell biosensors. Appl Microbiol Biotechnol 76: 1043-1050, 2007\r\n

    Asao M, Takaichi S, Madigan M T. Thiocapsa imhoffii, sp. nov., an alkaliphilic purple sulfur bacterium of the family Chromatiaceae from Soap Lake, Washington (USA). Arch Microbiol 188: 665-675, 2007\r\n

    Okada M, Taniuchi Y, Murakami A, Takaichi S, Ohtake S, Ohki K. Abundance of picophytoplankton in the halocline of meromictic lake, Lake Suigetsu, Japan. Limnology 8: 271-280, 2007\r\n

    Shindo K, Mikami K, Tamesada E, Takaichi S, Adachi K, Misawa N, Maoka T. Diapolycopenedioic acid xylosyl ester, a novel glyco-C30-carotenoic acid produced by a new marine bacterium Rubritalea squalenifaciens. Tetrahedron Lett 48: 2725-2727, 2007\r\n

    Sorokin DY, van Pelt S, Tourova TP, Takaichi S, Muyzer G. Acetonitrile degradation under haloalkaline conditions by Natronocella acetinitrilica gen. nov., sp. nov. Microbiology 153: 1157-1164, 2007\r\n

    Ishizuya-Oka A, Hasebe T, Shimizu K, Suzuki K, Ueda S. Shh\/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling. Dev Dyn 235: 3240-3249, 2006\r\n

    Takaichi S, Mochimaru M, Maoka T. Presence of free myxol and 4-hydroxymyxol and absence of myxol glycosides in Anabaena variabilis ATCC 29413, and proposal of biosynthetic pathway of carotenoids. Plant Cell Physiol 47: 211-216, 2006\r\n

    Takaichi S, Maoka T, Akimoto N, Khan ST, Harayama S. Major carotenoid isolated from Paracoccus schoinia NBRC 100637T is adonixanthin diglucoside. J Nat Prod 69: 1823-1825, 2006\r\n

    Ikuzawa M, Shimizu K, Yasumasu S, Iuchi I, Shi Y-B, Ishizuya-Oka A. Thyroid hormone-induced expression of a bZip-containing transcription factor activates epithelial cell proliferation during Xenopus larval-to-adult intestinal remodeling. Dev Genes Evol 216:109-118, 2005\r\n

    Fu L, Ishizuya-Oka A, Buchholz DR, Amano T, Shi Y-B. A causative role of stromelysin-3 in ECM remodeling and epithelial apoptosis during intestinal metamorphosis in Xenopus laevis. J Biol Chem 280: 27856-27865, 2005\r\n

    Ishizuya-Oka A, Shi Y-B. Molecular mechanisms for thyroid hormone-induced remodeling in the amphibian digestive tract: a model for studying organ regeneration. Dev Growth Differ 47: 601-607, 2005\r\n

    Banciu H, Sorokin DY, Rijpstra WIC, Damste JSS, Galinski EA, Takaichi S, Muyzer G, Kuenen JG. Fatty acid, compatible solute and pigment composition of obligately chemolithoautotrophic alkaliphilic sulfur-oxidizing bacteria from soda lakes. FEMS Microbiol Lett 243: 181-187, 2005\r\n

    Takaichi S, Mochimaru M, Maoka T, Katoh H. Myxol and 4-ketomyxol 2\uff0c-fucosides, not rhamnosides, from Anabaena sp. PCC 7120 and Nostoc punctiforme PCC 73102, and proposal for the biosynthetic pathway of carotenoids. Plant Cell Physiol 46: 497-504, 2005\r\n

    Tsuchiya T, Takaichi S, Misawa N, Maoka T, Miyashita H, Mimuro M. The cyanobacterium Gloeobacter violaceus PCC 7421 uses bacterial-type phytoene desaturase in carotenoid biosynthesis. FEBS Lett 579: 2125-2129, 2005.\r\n

    Gall A, Henry S, Takaichi S, Robert B, Cogdell Rj. Preferential incorporation of coloured-carotenoids occurs in the LH2 complexes from non-sulphur purple bacteria under carotenoid-limiting conditions. Photosynth Res 86: 25-35, 2005\r\n

    Maeda I, Yamashiro H, Yoshioka D, Onodera M, Ueda S, Miyasaka H, Umeda F, Kawase M, Takaichi S, Yagi K. Unusual accumulation of demethylspheroidene in anaerobic-phototrophic growth of crtA-deleted mutants of Rhodovulum sulfidophilum. Current Microbiol 51: 193-197, 2005\r\n

    Yoshii Y, Takaichi S, Maoka T, Suda S, Sekiguchi H, Nakayama T, Inouye I. Variation of siphonaxanthin series among the genus Nephroselmis (Prasinophyceae, Chlorophyta), including a novel primary methoxy carotenoid. J Phycol 41: 827-834, 2005\r\n

    Mochimaru M, Masukawa H, Takaichi S. The cyanobacterium Anabaena sp. PCC 7120 has two distinct b-carotene ketolases: CrtO for echinenone and CrtW for ketomyxol synthesis. FEBS Lett 579: 6111-6114, 2005\r\n

    Tojo M, Nishitani S. The effects of the smut fungus Microbotryum bistortarum on survival and growth of Polygonum viviparum in Svalbard, Norway. Can J Bot 83: 1513-1517, 2005\r\n

    Buchholz DR, Ishizuya-Oka A, Shi Y-B. Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis. Gene Express Patt 4: 321-328, 2004\r\n

    Akimoto S, Yamazaki I, Murakami A, Takaichi S, Mimuro M. Ultrafast excitation relaxation dynamics and energy transfer in the siphonaxanthin- containing green alga Codium fragile. Chem Phys Lett 390: 45-49, 2004\r\n

    Jung DO, Achenbach LA, Kar EA, Takaichi S, Madigan MT. A gas vesiculate planktonic strain of the purple-nonsulfur bacterium Rhodoferax antarcticus isolated from Lake Fryxell, Dry Valleys, Antarctica. Arch Microbiol 182: 236-243, 2004\r\n

    Takaichi S, Maoka T, Akimoto N, Sorokin D, Banciu H, Kuenen JG. Two novel yellow pigments natronochrome and chloronatronochrome from the natrono(alkali)philic sulfur-oxidizing bacterium Thialkalivibrio versutus strain ALJ 15. Tetrahedron Lett 45: 8303-8305, 2004\r\n

    Yatsunami R, Takaichi S, Nakamura S. Isolation of crtI homolog from extremely halophilic archaeon Haloarcula japonica strain TR-1. Nucleic Acids Symposium Series 48: 193-194, 2004\r\n <\/p>\r\n <\/div>\r\n <\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n

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