{"id":46,"date":"2025-09-19T19:12:06","date_gmt":"2025-09-19T10:12:06","guid":{"rendered":"https:\/\/www.nms.ac.jp\/iams\/?page_id=46"},"modified":"2025-12-15T17:16:57","modified_gmt":"2025-12-15T08:16:57","slug":"cell-biology","status":"publish","type":"page","link":"https:\/\/www.nms.ac.jp\/iams\/cell-biology\/","title":{"rendered":"\u7d30\u80de\u751f\u7269\u5b66\u5206\u91ce \u2013 \u7d30\u80de\u751f\u7269\u5b66\u90e8\u9580 \u2013"},"content":{"rendered":"<div class=\"p-under__mv\">\r\n  <div class=\"l-container\">\r\n    <div class=\"p-under__mv-title\">\r\n      <h1>\u7d30\u80de\u751f\u7269\u5b66<\/h1>\r\n      <p>\u2013 \u7d30\u80de\u751f\u7269\u5b66\u90e8\u9580 \u2013<\/p>\r\n    <\/div>\r\n  <\/div>\r\n<\/div>\r\n<div class=\"p-under__pan\">\r\n  <div class=\"l-container\">\r\n    <ul>\r\n      <li><a href=\"..\/\">TOP<\/a><\/li>\r\n      <li>\u7d30\u80de\u751f\u7269\u5b66<\/li>\r\n    <\/ul>\r\n  <\/div>\r\n<\/div>\r\n<main class=\"l-contents js-contents\">\r\n  <div 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               <\/p>\r\n                <h2 class=\"c-title04 u-mt-80 u-mt-sp-60\">\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\r\n                <ol class=\"c-list03 u-mt-40 u-mt-sp-30\">\r\n                  <li>\u304c\u3093\u514d\u75ab\u7642\u6cd5\u304a\u3088\u3073\u8a3a\u65ad\u6cd5\u306e\u958b\u767a<\/li>\r\n                  <li>\r\n                    \u514d\u75ab\u5fdc\u7b54\u306e\u500b\u4eba\u5dee\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\uff08T\u7d30\u80de\u8a18\u61b6\u304a\u3088\u3073\u30df\u30a8\u30ed\u30a4\u30c9\u30b7\u30d5\u30c8\uff09\r\n                  <\/li>\r\n                  <li>\r\n                    \u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u304a\u3051\u308b\u514d\u75ab-\u795e\u7d4c-\u5185\u5206\u6ccc\u7cfb\u306e\u76f8\u4e92\u4f5c\u7528\r\n                  <\/li>\r\n                <\/ol>\r\n                <h2 class=\"c-title04 u-mt-80 u-mt-sp-60\">\u672c\u7814\u7a76\u5ba4\u95a2\u9023\u30b5\u30a4\u30c8<\/h2>\r\n                <ul class=\"c-list01 u-mt-40 u-mt-sp-30\">\r\n                  <li>\r\n                    \u65e5\u672c\u5185\u79d1\u5b66\u4f1a\u96d1\u8a8c108\u5dfb9\u53f7 p.1766-1771, 2019 (\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u6a5f\u80fd\u3068\u764c\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u2015\u30cb\u30dc\u30eb\u30de\u30d6\u306e\u767a\u660e\u2015)\r\n                    <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/naika\/108\/9\/108_1766\/_pdf\/-char\/ja\" target=\"_blank\">https:\/\/www.jstage.jst.go.jp\/article\/naika\/108\/9\/108_1766\/_pdf\/-char\/ja<\/a>\r\n                  <\/li>\r\n                  <li>\r\n                    \u65e5\u672c\u533b\u79d1\u5927\u5b66\u5e83\u5831\u8a8cOne Health\u3000\u7b2c531\u53f7<br>\r\n                    <a href=\"https:\/\/www.nms.ac.jp\/iams\/assets\/file\/OneHealth531.pdf\" target=\"_blank\">https:\/\/www.nms.ac.jp\/iams\/assets\/file\/OneHealth531.pdf<\/a>\r\n                  <\/li>\r\n                  <li>\r\n                    2018\u5e74\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u533b\u5b66\u8cde\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<br>\r\n                    Press release: The Nobel Prize in Physiology or Medicine 2018<br>\r\n                    <a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2018\/press-release\/\" target=\"_blank\">https:\/\/www.nobelprize.org\/prizes\/medicine\/2018\/press-release\/<\/a>\r\n                    <a href=\"https:\/\/www.nobelprize.org\/uploads\/2018\/10\/press-medicine2018.pdf\" target=\"_blank\" class=\"c-link01 u-mt-10 u-mt-sp-10\">https:\/\/www.nobelprize.org\/uploads\/2018\/10\/press-medicine2018.pdf<\/a>\r\n                  <\/li>\r\n                <\/ul>\r\n\r\n              <\/div>\r\n              <div class=\"content\">\r\n                <h2 class=\"c-title04\">\u4e3b\u306a\u7814\u7a76\u696d\u7e3e<\/h2>\r\n\r\n                <ul class=\"c-list03 u-mt-30 u-mt-sp-20\">\r\n                  <li>\r\n                    Iwai Y, Okazaki T, Nishimura H, Kawasaki A, Yagita H, and Honjo T: Microanatomical localization of PD-1 in human tonsils. Immunol. Lett. 83:215, 2002.<br>\r\n                    \uff1c\u6297\u30d2\u30c8PD-1\u6297\u4f53\uff08\u30cb\u30dc\u30eb\u30de\u30d6\u539f\u578b\uff09\u306e\u4f5c\u88fd\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Freeman GJ\uff0a, Long AJ\uff0a, Iwai Y\uff0a\uff08\uff0a\u306fequal contributor\uff09, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, and Honjo T: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027-1034, 2000.<br>\r\n                    \uff1cPD-L1\u306e\u767a\u898b\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno N, Malenkovich N, Nichimura H, Okazaki T, Honjo T, Sharpe AH and Freeman GJ: PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 3:261-268, 2001.<br>\r\n                    \uff1cPD-L2\u306e\u767a\u898b\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, and Minato N: Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci., USA 99:12293-12297, 2002.<br>\r\n                    \uff1cPD-L1\u6297\u4f53\u306b\u3088\u308b\u6297\u816b\u760d\u52b9\u679c\u3001PD-1\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u304c\u3093\u306e\u514d\u75ab\u9003\u907f\u6a5f\u69cb\u306e\u767a\u898b\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Iwai Y, Terawaki S, and Honjo T: PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int. Immunol. 17:133-144, 2005.<br>\r\n                    \uff1cPD-1\u6297\u4f53\u306b\u3088\u308b\u304c\u3093\u8ee2\u79fb\u306e\u6291\u5236\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Iwai Y, Terawaki S, Ikegawa M, Okazaki T, and Honjo T: PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 198:39-50, 2003.<br>\r\n                    \uff1c\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u304a\u3051\u308bPD-1\u963b\u5bb3\u52b9\u679c\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Iwai Y, Hemmi H, Mizenina O, Kuroda S, Suda, K, and Steinman RM: An IFN-g-IL-18 signaling loop accelerates memory CD8+ T cell proliferation. PLoS ONE, 3:e2404, 2008.<br>\r\n                    \uff1c\u8a18\u61b6T\u7d30\u80de\u8a98\u5c0e\u30e2\u30c7\u30eb\u306e\u958b\u767a\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Kuroda S, Yamazaki M, Abe M, Sakimura K, Takayanagi H, and Iwai Y: Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression. Proc. Natl. Acad. Sci., USA, 108:14885-14889, 2011.<br>\r\n                    \uff1cBatf\u306b\u3088\u308b\u30ad\u30e9\u30fcT\u7d30\u80de\u5206\u5316\u5236\u5fa1\uff1e\r\n                  <\/li>\r\n                  <li>\r\n                    Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T: A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application. Nat Immunol. 14:1212-1218, 2013.<br>\r\n                    \uff1cPD-1\u7814\u7a76(\u57fa\u790e\u7814\u7a76\u304b\u3089\u81e8\u5e8a\u5fdc\u7528)\u306b\u3064\u3044\u3066\u306e\u7dcf\u8aac\uff1e\r\n                  <\/li>\r\n                <\/ul>\r\n                <p class=\"c-txt01-italic u-mt-20 u-mt-sp-10\">\r\n                  2, 5: Key publication from Press release: The Nobel Prize in Physiology or Medicine 2018<br>\r\n                  3, 4: References from Scientific backgrounds: The Nobel Prize in Physiology or Medicine 2018\r\n                <\/p>\r\n                <h4 class=\"c-title06 u-mt-60 u-mt-sp-40\">\r\n                  2018\r\n                <\/h4>\r\n                <ul class=\"c-list01 u-mt-20 u-mt-sp-10\">\r\n                  <li>\r\n                    Takeuchi M, Doi T, Obayashi K, Hirai A, Yoneda K, Tanaka F, Iwai Y: Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer. Immunology Letters. 196:155-160, 2018.\r\n                  <\/li>\r\n                <\/ul>\r\n                <h4 class=\"c-title06 u-mt-40 u-mt-30\">\r\n                  2024\r\n                <\/h4>\r\n                <ul class=\"c-list01 u-mt-20 u-mt-sp-10\">\r\n                  <li>\r\n                    Ando F, Kashiwada T, Kuroda S, Fujii T, Takano R, Miyabe Y, Kunugi S, Sakatani T, Miyanaga A, Asatsuma-Okumur Ta, Hashiguchi M, Kanazawa Y, Ohashi R, Yoshida H, Seike M, Gemma A, and Iwai Y. Combination of plasma MMPs and PD-1-binding soluble PD-L1 predicts recurrence in gastric cancer and the efficacy of immune checkpoint inhibitors in non-small cell lung cancer. Front Pharmacol. 15, 1384731, 2024.\r\n                  <\/li>\r\n                  <li>\r\n                    Kashiwada T, Takano R, Ando F, Kuroda S, Miyabe Y, Owada R, Miyanaga A, Asatsuma-Okumura T, Hashiguchi M, Kanazawa Y, Yoshida H, Seike M, Gemma A, and Iwai Y. Lysosomal degradation of PD-L1 is associated with immune-related adverse events during anti-PD-L1 immunotherapy in NSCLC patients. Front Pharmacol. 15, 1384733, 2024\r\n                  <\/li>\r\n                <\/ul>\r\n              <\/div>\r\n\r\n\r\n\t<div class=\"content\">\r\n\t\t<h2 class=\"c-title04\">\u7814\u7a76\u8005\u4e00\u89a7<\/h2>\r\n\r\n\t\t<!-- \u30b5\u30e0\u30cd\u30a4\u30eb\u3042\u308a -->\r\n\t\t<div class=\"c-box02-wrap\">\r\n\t\t\t\t\t\t\t\t<div class=\"c-box02 u-mt-30 u-mt-sp-20\">\r\n\t\t\t\t\t\t<div class=\"c-box02-img\">\r\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"825\" height=\"1040\" src=\"https:\/\/www.nms.ac.jp\/iams\/msup\/wp-content\/uploads\/2025\/10\/\u753b\u50cf1.jpg\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/>\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div class=\"c-box02-txt\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span>\u5927\u5b66\u9662\u6559\u6388<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3>\u5ca9\u4e95\u3000\u4f73\u5b50<\/h3>\r\n\t\t\t\t\t\t\t<div class=\"c-box02-link\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/researchmap.jp\/3_krtn\" class=\"c-link02\" target=\"_blank\">\r\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.nms.ac.jp\/iams\/assets\/images\/common\/icon05.svg\" alt=\"\">\r\n\t\t\t\t\t\t\t\t\t\t<p>researchmap<\/p>\r\n\t\t\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/iwai.labby.jp\/\" class=\"c-link02\" target=\"_blank\">\r\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.nms.ac.jp\/iams\/assets\/images\/common\/icon05.svg\" alt=\"\">\r\n\t\t\t\t\t\t\t\t\t\t<p>\u7d30\u80de\u751f\u7269\u5b66\u3000\u79c1\u8a2dHP<\/p>\r\n\t\t\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\r\n\t\t<!-- \u30b5\u30e0\u30cd\u30a4\u30eb\u306a\u3057 -->\r\n\t\t<div class=\"c-box03 u-mt-40 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class=\"c-box03-link\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/researchmap.jp\/r-owada\" class=\"c-link02\" target=\"_blank\">\r\n\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.nms.ac.jp\/iams\/assets\/images\/common\/icon05.svg\" alt=\"\">\r\n\t\t\t\t\t\t\t\t\t\t\t<p>researchmap<\/p>\r\n\t\t\t\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t\t\t<li>\r\n\t\t\t\t\t\t\t<span>\u5289\u3000\u7389\u7965<\/span>\r\n\t\t\t\t\t\t\t<p class=\"c-box03-txt\">\u52a9\u6559<\/p>\t\t\t\t\t\t\t<div class=\"c-box03-link-wrap\">\r\n\t\t\t\t\t\t\t\t<div class=\"c-box03-link\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/researchmap.jp\/liuyuxiang\" class=\"c-link02\" target=\"_blank\">\r\n\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.nms.ac.jp\/iams\/assets\/images\/common\/icon05.svg\" alt=\"\">\r\n\t\t\t\t\t\t\t\t\t\t\t<p>researchmap<\/p>\r\n\t\t\t\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t\t\t<li>\r\n\t\t\t\t\t\t\t<span>\u5927\u585a\u3000\u7dbe\u9999<\/span>\r\n\t\t\t\t\t\t\t<p class=\"c-box03-txt\">\u30a2\u30b7\u30b9\u30bf\u30f3\u30c8\u30b5\u30dd\u30fc\u30c8\u30fb\u30b9\u30bf\u30c3\u30d5<\/p>\t\t\t\t\t\t\t<div class=\"c-box03-link-wrap\">\r\n\t\t\t\t\t\t\t\t<div class=\"c-box03-link\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t<\/ul>\r\n\t\t<\/div>\r\n\t<\/div>\r\n\r\n\r\n\r\n\r\n            <\/div>\r\n          <\/div>\r\n        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n  <\/div>\r\n\r\n<\/main>\r\n\r\n","protected":false},"excerpt":{"rendered":"\u7d30\u80de\u751f\u7269\u5b66 \u2013 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