ENGLISH

遺伝子制御学- 遺伝子制御学部門 -

ようこそ遺伝子制御学講座(先端医学研究所 遺伝子制御学部門)へ

私達の研究室は、癌抑制遺伝子産物の機能解析、特にアポトーシスや細胞周期制御の分子機構を解析することで、生体に備わっている癌に対する防御機構を明らかにすることを目的に研究を行っています。

遺伝子制御学講座(先端医学研究所 遺伝子制御学部門)へのお問い合わせ

TEL: 044-733-1860(教授室直通)
FAX: 044-733-1294
E-mail: ig-moloncol@nms.ac.jp

業績

2009年 業績

  • Kawauchi K, Araki K, Tobiume K, Tanaka N. (2009) Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. Proc. Natl. Acad. Sci. USA, 106:3431-3436.

2008年 業績

  • Kawauchi K, Araki K, Tobiume K, Tanaka N. (2008) p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation. Nat. Cell Biol., 10:611-618.
  • Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N., (2008) Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proc. Natl. Acad. Sci. USA, 105:4838-4843.
  • Kawauchi K, Araki K, Tobiume K, Tanaka N. (2008) Activated p53 induces NF-κB DNA binding but suppresses its transcriptional activation. Biochem. Biophys. Res. Commun., 372:137-141.
  • Araki K, Kawauchi K, Tanaka N. (2008) IKK/NF-κB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors. Oncogene. 2008, 25;27(43):5696-705.

その他 代表的論文

  • Shibue T, Takeda K, Oda E, Tanaka H, Murasawa H, Takaoka A, Morishita Y, Akira S, Taniguchi T, Tanaka N. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev., 15: 2233-2238.
  • Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., and Tanaka, N. (2000). Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288, 1053-1058.
  • Takaoka, A., Mitani, Y., Suemori, H., Sato, M., Yokochi, T., Noguchi, S., Tanaka, N., and Taniguchi, T. (2000). Cross talk between interferon-γ and -α/β signaling components in caveolar membrane domains. Science 288, 2357-2360.
  • Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., and Taniguchi, T. (2000). Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction. Immunity 13, 539-548.
  • Nozawa, H., Oda, E., Nakao, K., Ishihara, M., Ueda, S., Yokochi, T., Ogasawara, K., Nakatsuru, Y., Shimizu, S., Ohira, Y., Hioki, K., Aizawa, S., Ishikawa, T., Katsuki, M., Muto, T., Taniguchi, T., and Tanaka, N. (1999). Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. Genes Dev. 13, 1240-1245.
  • Tanaka, N., Ishihara, M., Lamphier, M. S., Nozawa, H., Matsuyama, T., Mak, T. W., Aizawa, S., Tokino, T., Oren, M., and Taniguchi, T. (1996). Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature 382, 816-818.
  • Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., and Taniguchi, T. (1995). An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376, 596-599.
  • Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., and Taniguchi, T. (1994). Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77, 829-839.
  • Kimura, T., Nakayama, K., Penninger, J., Kitagawa, M., Harada, H., Matsuyama, T., Tanaka, N., Kamijo, R., Vilcek, J., Mak, T. W., and Taniguchi, T. (1994). Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264, 1921-1924.
  • Harada, H., Kitagawa, M., Tanaka, N., Yamamoto, H., Harada, K., Ishihara, M., and Taniguchi, T. (1993). Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science 259, 971-974.
  • Willman, C. L., Sever, C. E., Pallavicini, M. G., Harada, H., Tanaka, N., Slovak, M. L., Yamamoto, H., Harada, K., Meeker, T. C., List, A. F., and Taniguchi, T. (1993). Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science 259, 968-971.