Regulation of Ca2+ Channels in Immature Cardiomyocytes and Developmental Changes
Department of Pediatrics, Musashikosugi Hospital, Nippon Medical School
The electrophysiology of the heart changes dramatically during development. These changes in electrical properties are caused by changes in the number (density) and types of ion channels, with resultant changes in the magnitude and kinetic properties of the various types of ionic currents. The alterations in the ion channels are resposible for the changes in the resting potential and characteristics of the action potentials. In this review, we focused on the developmental changes of the L-type Ca2+ channel (especially its regulation via β-adrenoceptor, and muscarinic acetylcholine agonsist, tyrosine kinase) and the T-type Ca2+ channel. As mentioned in this review, the immature heart differs from the adult heart in both size and function. Therefore, we have to pay attention to the characteristics of the immature heart when we treat neonates and children.
ϊγεγο 2006; 2(2), 96-102
ion channel, Ca2+ channel, development, immature heart, patch-clamp
Yasuhiro Katsube, Department of Pediatrics, Musashikosugi Hospital, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan