第2巻 2006年4月　第2号

■綜説

未熟心筋Ca^2＋電流の調節とその発達に伴う変化
勝部　康弘
日本医科大学武蔵小杉病院小児科

Regulation of Ca²⁺ Channels in Immature Cardiomyocytes and Developmental Changes
Yasuhiro Katsube
Department of Pediatrics, Musashikosugi Hospital, Nippon Medical School

The electrophysiology of the heart changes dramatically during development. These changes in electrical properties are caused by changes in the number (density) and types of ion channels, with resultant changes in the magnitude and kinetic properties of the various types of ionic currents. The alterations in the ion channels are resposible for the changes in the resting potential and characteristics of the action potentials. In this review, we focused on the developmental changes of the L-type Ca²⁺ channel (especially its regulation via β-adrenoceptor, and muscarinic acetylcholine agonsist, tyrosine kinase) and the T-type Ca²⁺ channel. As mentioned in this review, the immature heart differs from the adult heart in both size and function. Therefore, we have to pay attention to the characteristics of the immature heart when we treat neonates and children.

日医大医会誌 2006; 2(2), 96-102

Key words
ion channel, Ca²⁺ channel, development, immature heart, patch-clamp

Correspondence to
Yasuhiro Katsube, Department of Pediatrics, Musashikosugi Hospital, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan
E-mail：katsube@nms.ac.jp

受付：2005年10月4日　受理：2005年11月29日