■綜説
結晶構造からみた尿酸生成抑制剤の阻害機構
岡本 研
日本医科大学生化学第一
Inhibition Mechanisms of Xanthine Oxidoreductase Inhibitors
Ken Okamoto
Department of Biochemistry and Molecular Biology, Nippon Medical School
Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR block conversion of the oxypurines (hypoxanthine and xanthine) to uric acid, thus decreasing serum concentration of uric acid. Crystal structures of XOR- ibnhibitor complexes reveal that each inhibitor has different inhibition mechanisms, utilizing the enzyme structure and the reaction mechanism. Such variation of the inhibition mechanism affects in vivo hypouricemic effects of the inhibitors.
日医大医会誌 2007; 3(2), 83-88
Key words
xanthine oxidoreductase, inhibitor, gout drug
Correspondence to
Ken Okamoto, Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
E-mail：okamoto@nms.ac.jp
受付：2007年1月12日 受理：2007年2月21日 |
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