第4巻 2008年2月　第1号

■綜説

眼内炎症反応の成立と抗原提示過程
山木　邦比古
日本医科大学大学院医学研究科感覚器視覚機能医学
日本医科大学千葉北総病院眼科

Intraocular Inflammation and Antigen Presentation
Kunihiko Yamaki
Department of Vision and Ophthalmology, Graduate School of Medicine, Nippon Medical School
Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital

Intraocular space is thought to be an immune privileged site. One of the most well known facts is that the corneal plantation is successful even if the donor's MHC molecules doesn't match with the recipient's. However, still this doesn't mean that the immune reaction is completely inhibited in the intraocular tissue, since the intraocular herpes infection develops fulminate immune inflammation known as acute retinal necrosis.
For explaining these complicated intraocular immune responses, in which some immune reactions are inhibited while others develop immuneinflammation, it is required to study the antigen presenting process in the intraocular tissue. And since there isn't much reports about whether the antigen presentation process in the intraocular tissue takes place or not in this paper we show preliminary results indicating the existence of potential cells able to present antigens. We also review recent literature reporting the immune reactions in intraocular tissue and central nervous systems.

日医大医会誌 2008; 4(1), 8-14

Key words
antigen presentation, intraocular tissue, antigen uptake, antigen presenting cells

Correspondence to
Kunihiko Yamaki, Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari Inba-mura, Inba-gun, Chiba, 270-1694, Japan
E-mail：kyamaki@nms.ac.jp

受付：2007年9月5日　受理：2007年10月17日