■臨床医のために
骨粗鬆症の診断と治療
河路 秀巳, 伊藤 博元
日本医科大学大学院医学研究科感覚運動機能再建学
Diagnosis and Treatment of Osteoporosis
Hidemi Kawaji and Hiromoto Ito
Division for Restorative medicine of neuro-muscuroskeletal system, Graduate School of Medicine, Nippon Medical School
In Japan, since the number of patients with osteoporosis totals more than 10 million, we have numerous chances to examine such patients.
In this review, I would like to describe the diagnosis and treatment of osteoporosis based on up-to-date knowledge.
Patients with osteoporosis usually complain of chronic back or lower back pain.
Pain in patients with osteoporosis is brought about by fractures due to osteoporotic (fragile) bone. Common fractures seen in osteoporosis are those of the proximal femur, proximal humerus, vertebral body, and distal end of the radius.
Diagnosis should be established based on the findings of X-ray images of the lumbar spine or proximal femur and bone mineral density (BMD) in accordance with the diagnostic criteria proposed in 2000 by the Japanese Society for Bone and Mineral Research.
The aim of osteoporosis treatment is to prevent fractures complicated with compromised bone strength. Preventing the loss of activities in daily life, the quality of life of patients with osteoporosis must be maintained.
Now, we are able to prescribe two kinds of drug to increase the BMD and prevent fractures: bisphosphonates and SERM (selective estrogen receptor modulator). Sufficient evidence for the efficacy of both drugs has been accumulated, and they are strongly recommended.
日医大医会誌 2009; 5(1), 41-46
Key words
osteoporosis, fracture, bisphosphonate, SERM
Correspondence to
Hidemi Kawaji, Department of Orthopaedic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
E-mail：nyao@nms.ac.jp
受付：2008年12月15日 受理：2009年1月9日 |
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