■綜説
アトピー性皮膚炎病因論における諸問題
幸野 健
日本医科大学大学院医学研究科皮膚粘膜病態学
Recent Issues in the Etiology of Atopic Dermatitis
Takeshi Kono
Department of Cutaneous and Mucosal Pathophysiology, Graduate School of Medicine, Nippon Medical School
Despite extensive investigation of genes related to atopic dermatitis, the etiology of the disease has not been clarified. The results of epidemiological studies of atopic dermatitis suggest that it should be viewed as a multidimensional phenomenon and that various pathogenetic hypotheses should be evaluated. In this article, several noteworthy topics in the pathogenesis of atopic dermatitis are reviewed, namely, international epidemiological studies, migration studies, and family size or socioeconomic research. The so-called "old mother hypothesis" and the fetal programming theory are also discussed.
日医大医会誌 2011; 7(2), 83-87
Key words
atopic dermatitis, etiology, pathogenesis, epidemiology, migration study
Correspondence to
Takeshi Kono, Department of Cutaneous and Mucosal Pathophysiology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku Tokyo 113-8603, Japan
E-mail：konotks@nms.ac.jp
受付：2011年1月20日 受理：2011年2月1日 |
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