■基礎研究から学ぶ
3.遺伝子導入と発現シリーズ ウイルスベクターによる遺伝子導入と発現（5）
三宅 弘一, 島田 隆
日本医科大学生化学・分子生物学（分子遺伝学）
3. Gene Delivery and Expression Series Viral Vector Mediated Gene Delivery and Expression (5)
Koichi Miyake and Takashi Shimada
Department of Biochemistry and Molecular Biology, Nippon Medical School
Most of the candidate tissues for in vivo gene transfer are made of quiescent cells, such as from the brain, liver, and muscle. Thus, the optimal vector should infect non-dividing cells. Recently, many type of adeno-associated virus (AAV) vectors have been developed and used in vivo gene transfer. This technical note focuses on the in vivo gene transfer using AAV vectors. We discuss about how to choose the appropriate viral vector to transduce target organs in vivo.
日医大医会誌 2012; 8(3), 216-221
Key words
in vivo gene transfer, lentiviral vector, adenoviral vector, adeno-associated viral vector
Correspondence to
Koichi Miyake, Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
E-mail：kmiyake@nms.ac.jp
受付：2012年5月14日 受理：2012年6月13日 |
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