■基礎科学から医学・医療を見る
薬物代謝の化学反応―シトクロムP450反応を中心として
中村 成夫
日本医科大学基礎科学化学
Chemical Reaction of Drug Metabolism: Reactivity of cytochrome P450
Shigeo Nakamura
Department of Chemistry, Nippon Medical School
Drug metabolism involves chemical reactions modifying pharmaceutical substances. Lipophilic chemical compounds are converted to hydrophilic compounds by enzymes related to drug metabolism. Some drugs are activated after drug metabolism; on the other hand, some xenobiotic compounds become toxic through these enzymes. Cytochrome P450 is an enzyme that plays a major role in drug metabolism. Metabolites produced by cytochrome P450 from one drug are predictable from the viewpoint of chemical reactivity. Novel metabolites from nonylphenol and bisphenol A are discovered considering the ipso-position metabolic reaction of cytochrome P450.
日医大医会誌 2013; 9(1), 25-30
Key words
cytochrome P450, drug metabolism, endocrine disruptor, ipso-addition, ipso-substitution
Correspondence to
Shigeo Nakamura, Department of Chemistry, Nippon Medical School, 2-297-2 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-0063, Japan
E-mail：shigeo-nakamura@nms.ac.jp
受付：2012年10月31日 受理：2012年12月13日 |
全文PDF