■基礎科学から医学・医療を見る
活性酸素と抗酸化物質の化学
中村 成夫
日本医科大学基礎科学化学
Chemistry of Reactive Oxygen Species and Antioxidants
Shigeo Nakamura
Department of Chemistry, Nippon Medical School
Reactive oxygen species (ROS) are produced from molecular oxygen. ROS are the reduced forms of molecular oxygen and have high reactivity to biological components e.g. lipid, protein, and nucleic acid. ROS are considered to cause various diseases e.g. arteriosclerosis, myocardial infarction, cancer, and so on. A living body protects against ROS by antioxidant enzymes e.g. superoxide dismutase (SOD) and catalase. Natural antioxidants e.g. ascorbic acid (vitamin C) and α-tocopherol (vitamin E) also scavenge ROS. Recently, some novel artificial antioxidants are synthesized and are expected to a lead compound for drugs.
日医大医会誌 2013; 9(3), 164-169
Key words
reactive oxygen species, free radical, oxidative stress, antioxidant, radical scavenger
Correspondence to
Shigeo Nakamura, Department of Chemistry, Nippon Medical School, 2-297-2 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-0063, Japan
E-mail：shigeo-nakamura@nms.ac.jp
受付：2013年2月19日 受理：2013年3月5日 |
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