第10巻 2014年2月　第1号

■症例報告

ヒドロキシカルバミドによる下腿潰瘍の1例
田村　奈渚, 上野　孝, 尾見　徳弥, 川名　誠司
日本医科大学皮膚科学

A Case of Leg Ulcers due to Hydroxycarbamide
Nao Tamura, Takashi Ueno, Tokuya Omi and Seiji Kawana
Department of Dermatology, Nippon Medical School

Hydroxycarbamide, also known as hydroxyurea, is a nucleic-acid metabolic antagonist used to treat myeloproliferative disorders, such as chronic myelocytic leukemia, polycythemia vera, and essential thrombocythemia. We present an 85-year-old woman in whom skin ulcers developed on the posterior aspect of the calcaneal region bilaterally after she was treated with hydroxycarbamide for essential thrombocythemia. The ulcers were resistant to conventional therapy but healed 1 month after the discontinuation of hydroxyurea and the application of a steroid ointment. Clinicians should therefore be aware of this potential adverse effect of hydroxycarbamide.

日医大医会誌 2014; 10(1), 13-15

Key words
skin ulcer, hydroxycarbamide, Hydrea, essential thrombocythemia

Correspondence to
Nao Tamura, Department of Dermatology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku Tokyo 113-8603, Japan
E-mail：naotamu70@nms.ac.jp

受付：2013年9月13日　受理：2013年10月28日