第13巻 2017年6月　第3号

■綜説

脳浮腫とフリーラジカル
池田　幸穂
東京医科大学八王子医療センター脳神経外科

Brain Edema and Free Radicals
Yukio Ikeda
Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center

This review outlines the basic concepts and pathophysiological aspects of the chemistry of free radicals in all forms of brain injury and brain edema. Brain edema, defined as an abnormal accumulation of fluid associated with volumetric enlargement of the brain, is complicated and multifactorial, and it is still a serious complication of strokes, brain tumors, brain abscesses and hypoxic injury. Recent experimental studies have demonstrated that free radicals play an important role as chemical mediators in causing brain edema and brain damage. Pharmacological antagonism of free radicals with free radical scavengers shows beneficial therapeutic results. Future research into brain edema and optimal combinations of therapeutic regimens is expected to improve the management of patients with brain edema.

日医大医会誌 2017; 13(3), 120-129

Key words
brain edema, brain injury, free radicals

Correspondence to
Yukio Ikeda, Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachiojishi Tokyo 193-0998, Japan
E-mail：y-ikeda@tokyo-med.ac.jp

受付：2017年2月14日　受理：2017年4月3日