■症例報告
水腎は増悪するが閉塞性腎障害が進行しない巨大水腎症の2例
竹下 絵理1, 高橋 翼2, 柳原 剛1
1日本医科大学武蔵小杉病院小児科
2日本医科大学武蔵小杉病院小児外科
Two cases with severe hydronephrosis not developing obstructive nephropathy
Eri Takeshita1, Tsubasa Takahashi2 and Takeshi Yanagihara1
1)Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital
2)Department of Pediatric Surgery, Nippon Medical School Musashi Kosugi Hospital
Congenital ureteropelvic junction obstruction (UPJO) is one of the most common causes of hydronephrosis in children. We report on 2 patients with severe hydronephrosis detected prenatally who did not develop obstructive nephropathy after birth. The pathogenesis of the dilation in both patients was UPJO. Although much controversy still surrounds the clinical significance of antenatal hydronephrosis and the management of patients, our follow-up for these 2 patients consisted just of serial blood tests, urine tests and technetium-99m-labeled dimercaptosuccinic acid renal scintigraphy (DMSA). Patient 1 had bilateral hydronephrosis, and the renal uptake of DMSA in the right kidney was severely decreased. Therefore, we performed a right percutaneous nephrostomy and observed the left kidney conservatively. By the time the patient was 18 months old, the hydronephrosis of the left kidney had developed considerably, with the kidney reaching into the pelvic cavity; however, there was no decrease in the renal uptake of the kidney. Hydronephrosis was also detected prenatally in the right kidney of Patient 2, but the left kidney was morphologically and functionally normal. At the age of 8 months, the patient developed acute focal bacterial nephritis (FBN) in the right kidney, with decreased renal uptake. There was no subsequent decrease in renal uptake, but the hydronephrosis worsened, and the kidney increased drastically in size. Some researchers recommend early surgical intervention in cases of severe UPJO to achieve early relief from obstruction. However, as shown in this report, some patients show no degeneration of kidney function in spite of worsening hydronephrosis. Careful consideration of the risks associated with general anesthesia and surgery are needed before deciding on treatment.
日医大医会誌 2017; 13(3), 136-139
Key words
prenatal hydronephrosis, ureteropelvic junction obstruction, conservative therapy, surgery, dimercaptosuccinic acid
Correspondence to
Takeshi Yanagihara, Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki Kanagawa 211-8533, Japan
E-mail：yagi@nms.ac.jp
受付：2017年2月17日 受理：2017年4月5日 |
全文PDF