■特集〔動脈硬化症 基礎から臨床へ〕
高血糖と動脈硬化〜マウスを用いた動物実験の成績から〜
浅井 明1, 2
1日本医科大学大学院医学研究科内分泌糖尿病代謝内科学分野
2東北大学大学院農学研究科食の健康科学ユニット
Hyperglycemia and Atherosclerosis: Experimental Results in Mice
Akira Asai1, 2
1)Department of Endocrinology, Diabetes and Metabolism, Nippon Medical School Graduate School of Medicine
2)Food and Health Science Research Unit, Tohoku University Graduate School of Agricultural Science
Epidemiological evidence indicates that patients with diabetes mellitus are at increased risk for atherosclerotic cardiovascular and cerebrovascular diseases. Furthermore, recent reports have demonstrated that the risk for atherosclerotic events is increased even in individuals in a pre-diabetic state, for example in those with impaired glucose tolerance. Although a number of studies have investigated the molecular mechanisms underlying the causal role of hyperglycemia (both chronic and transient) in the pathogenesis of atherosclerosis, little compelling evidence has been found in vivo. This article summarizes the potentials and pitfalls of using mouse models to study hyperglycemia-induced atherosclerosis in the hope of elucidating its complicated molecular mechanisms.
日医大医会誌 2017; 13(4), 194-198
Key words
atherosclerosis, diabetes mellitus, impaired glucose tolerance, hyperglycemia, mouse models
Correspondence to
Akira Asai, Food and Health Science Research Unit, Tohoku University Graduate School of Agricultural Science, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-0845, Japan
E-mail：akira.asai.b3@tohoku.ac.jp
受付：2017年7月31日 受理：2017年8月9日 |
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