第16巻 2020年2月　第1号

■綜説

ケロイドの病態と治療
土佐　眞美子, 小川　令
日本医科大学付属病院形成外科・再建外科・美容外科

Pathogenesis and Treatment of Keloids
Mamiko Tosa and Rei Ogawa
Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School

Keloids are chronic inflammatory fibrous tumors that cause excessive production of such extracellular macromolecules as collagen, due to the overexpression of various growth factors and cytokines. The etiology of keloids is unknown. They cause pain and itching, which together with the red mass leads to physical and mental stress in patients. No definitive treatment for keloids has been established, although various treatment methods have been reported, and the current consensus is that the recurrence of keloids cannot be completely suppressed. Elucidation is awaited of the pathologic mechanism of keloid development and identification of signal transduction pathways that will help establish a molecular targeted therapy for keloids.

日医大医会誌 2020; 16(1), 8-17

Key words
keloids, pathogenesis, treatment

Correspondence to
Mamiko Tosa, Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
E-mail：tosa-m@nms.ac.jp

受付：2019年12月5日　受理：2019年12月19日