Journal of Nippon Medical School: Vol.66 No.1 page.033

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ArticleTitle Effect of age on urinary excretion of N-acetyl-β-D-glucosaminidase

AuthorList Kenzo Oba, Masaaki Hirai, Yumiko Ajiro, Kyoji Okazaki, Shuzo Sato, Keiko Sasai, Tatsuya Suzuki, Hiroshi Nakano and Shohei Metori

Affiliation The Division of Geriatric Medicine, Nippon Medical School

Language EN

Volume 66

Issue 1

Year 1999

Page 33-36

Received October 19, 1998

Accepted December 4, 1998

Keywords N-acetyl-β-D-glucosaminidase, aging, blood pressure

Abstract To examine the relationship between the concentrations of urinary NAG and age, we measured ratios of urinary N-acetyl-β-D-glucosaminidase (NAG) to urinary creatinine (NAG index) in 137 healthy subjects, aged from 19 to 88 years. The study is also designed to evaluate the relationship between urinary NAG and blood pressure. The subjects were divided into 7 subgroups, according to their age (< 30, 30-39, 40-49, 50-59, 60-69, 70-79, 80 or more years). There was a positive correlation between NAG index and age (r=0.36; P< 0.001). The regression equation relating NAG index (y) to age (x) was y=0.065x+0.97. The mean NAG indexes for the 7 subgroups divided by age were significantly different (P< 0.01). There was a positive correlation between NAG index and systolic blood pressure (r=0.18; P< 0.05), but was not between diastolic blood pressure and NAG index. In multiple regression analysis, age and BUN significantly correlated with NAG index (r=0.32; P< 0.01, r=3.3; P=0.07, respectively), although there was no correlation between systolic blood pressure and NAG index. This cross-sectional study showed a clear elevation in NAG index with age. The rate of elevation was 0.65 per decade. Urinary excretion of NAG may be unrelated to blood pressure.

Correspondence to Kenzo Oba MD, The Division of Geriatric Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan

ArticleTitle	Effect of age on urinary excretion of N-acetyl-β-D-glucosaminidase
AuthorList	Kenzo Oba, Masaaki Hirai, Yumiko Ajiro, Kyoji Okazaki, Shuzo Sato, Keiko Sasai, Tatsuya Suzuki, Hiroshi Nakano and Shohei Metori
Affiliation	The Division of Geriatric Medicine, Nippon Medical School
Language	EN
Volume	66
Issue	1
Year	1999
Page	33-36
Received	October 19, 1998
Accepted	December 4, 1998
Keywords	N-acetyl-β-D-glucosaminidase, aging, blood pressure
Abstract	To examine the relationship between the concentrations of urinary NAG and age, we measured ratios of urinary N-acetyl-β-D-glucosaminidase (NAG) to urinary creatinine (NAG index) in 137 healthy subjects, aged from 19 to 88 years. The study is also designed to evaluate the relationship between urinary NAG and blood pressure. The subjects were divided into 7 subgroups, according to their age (< 30, 30-39, 40-49, 50-59, 60-69, 70-79, 80 or more years). There was a positive correlation between NAG index and age (r=0.36; P< 0.001). The regression equation relating NAG index (y) to age (x) was y=0.065x+0.97. The mean NAG indexes for the 7 subgroups divided by age were significantly different (P< 0.01). There was a positive correlation between NAG index and systolic blood pressure (r=0.18; P< 0.05), but was not between diastolic blood pressure and NAG index. In multiple regression analysis, age and BUN significantly correlated with NAG index (r=0.32; P< 0.01, r=3.3; P=0.07, respectively), although there was no correlation between systolic blood pressure and NAG index. This cross-sectional study showed a clear elevation in NAG index with age. The rate of elevation was 0.65 per decade. Urinary excretion of NAG may be unrelated to blood pressure.
Correspondence to	Kenzo Oba MD, The Division of Geriatric Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan