Journal of Nippon Medical School: Vol.66 No.3 page.176

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ArticleTitle The influence of hypothyroidism on wound healing An experimental study

AuthorList Joji Natori, Kazuo Shimizu, Mitsuji Nagahama, and Shigeo Tanaka

Affiliation Department of Surgery II, Nippon Medical School

Language EN

Volume 66

Issue 3

Year 1999

Page 176-180

Received June 19, 1998

Accepted March 11, 1999

Keywords hypothyroidism, wound healing, hydroxyproline, collagen

Abstract An expe rimental study was performed to investigate the influence of hypothyroidism on wound healing. A state of severe hypothyroidism was induced initially by performing a total thyroidectomy on rat models; subsequently wounds were made by making long midline abdominal incisions and then suturing them. The parameters used to evaluate the process of wound healing of these incisions were the assay of type-I collagen, type-III collagen (procollagen peptide PIPC and P III P, each being the precursor of collagen), type-IV collagen, and hydroxyproline. The assays were repeated at specific times and compared to assays of similar parameters taken from a control group. In the state of hypothyroidism, a decrease was observed in type-IV collagen and hydroxyproline during the proliferative phase of wound healing. This indicated that the state of hypothyroidism constitutes an important factor in delaying wound healing.

Correspondence to Dr. Kazuo Shimizu, Department of Surgery II, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

ArticleTitle	The influence of hypothyroidism on wound healing An experimental study
AuthorList	Joji Natori, Kazuo Shimizu, Mitsuji Nagahama, and Shigeo Tanaka
Affiliation	Department of Surgery II, Nippon Medical School
Language	EN
Volume	66
Issue	3
Year	1999
Page	176-180
Received	June 19, 1998
Accepted	March 11, 1999
Keywords	hypothyroidism, wound healing, hydroxyproline, collagen
Abstract	An expe rimental study was performed to investigate the influence of hypothyroidism on wound healing. A state of severe hypothyroidism was induced initially by performing a total thyroidectomy on rat models; subsequently wounds were made by making long midline abdominal incisions and then suturing them. The parameters used to evaluate the process of wound healing of these incisions were the assay of type-I collagen, type-III collagen (procollagen peptide PIPC and P III P, each being the precursor of collagen), type-IV collagen, and hydroxyproline. The assays were repeated at specific times and compared to assays of similar parameters taken from a control group. In the state of hypothyroidism, a decrease was observed in type-IV collagen and hydroxyproline during the proliferative phase of wound healing. This indicated that the state of hypothyroidism constitutes an important factor in delaying wound healing.
Correspondence to	Dr. Kazuo Shimizu, Department of Surgery II, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan