Journal of Nippon Medical School: Vol.66 No.3 page.181

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ArticleTitle The relationship between p53 protein and c-erb B-2 expression and apoptosis in colorectal cancer

AuthorList Qun He^{1, 4)} , Yoshiharu Ohaki¹⁾ , Noritake Tanaka²⁾ , Goro Asano³⁾

Affiliation ¹⁾ Department of Pathology, ²⁾ Department of Surgery, Nippon Medical School, Chiba Hokusou Hospital ³⁾ Department of Pathology, Nippon Medical School ⁴⁾ Department of Pathology, Beijing Medical University, First Teaching Hospital

Language JA

Volume 66

Issue 3

Year 1999

Page 181-187

Received January 29, 1999

Accepted March 18, 1999

Keywords invasive forefront of colorectal carcinoma, p53, c-erb B-2, apoptosis, inflammatory cell infiltration

Abstract In order to elucidate the relationship between tumor growth and various kinds of gene expression and the occurrence of apoptosis in the front portion of neoplastic invasion, 57 advanced colorectal cancers were studied by immunohistochemical staining of p53, c-erb B-2, the TUNEL method and electron microscopy. Light microscopically, the columnar epithelial cells of adenocarcinoma frequently showed a decrease in high and a fall off into the lumen in tumor invasive forefront. Immunohistochemically the positive rate of p53 and c-erb B-2 in tumors with high vascular invasion were higher (p< 0.05) than in those with low vascular invasion. There was a close correlation between the vascular or lymphatic invasion and positive immunoreactivity of p53 and c-erb B-2. The apoptosis index was demonstrated to be related to vessel invasion, over expression of p53 and inflammatory cell infiltration around the front portion of the tumor invasion. These results suggested that p53, c-erb B-2 and the apoptosis index should be evaluated in conjunction with the prognostic factors in colorectal cancer. The infiltrative inflammatory cells may induce apoptosis of the tumor cells.

Correspondence to Qun He, Department of Pathology, Nippon Medical School, Chiba Hokusou Hospital, 1715 Kamakari Inba-mura, Inba-gun, Chiba 270-1694, Japan

ArticleTitle	The relationship between p53 protein and c-erb B-2 expression and apoptosis in colorectal cancer
AuthorList	Qun He^{1, 4)} , Yoshiharu Ohaki¹⁾ , Noritake Tanaka²⁾ , Goro Asano³⁾
Affiliation	¹⁾ Department of Pathology, ²⁾ Department of Surgery, Nippon Medical School, Chiba Hokusou Hospital ³⁾ Department of Pathology, Nippon Medical School ⁴⁾ Department of Pathology, Beijing Medical University, First Teaching Hospital
Language	JA
Volume	66
Issue	3
Year	1999
Page	181-187
Received	January 29, 1999
Accepted	March 18, 1999
Keywords	invasive forefront of colorectal carcinoma, p53, c-erb B-2, apoptosis, inflammatory cell infiltration
Abstract	In order to elucidate the relationship between tumor growth and various kinds of gene expression and the occurrence of apoptosis in the front portion of neoplastic invasion, 57 advanced colorectal cancers were studied by immunohistochemical staining of p53, c-erb B-2, the TUNEL method and electron microscopy. Light microscopically, the columnar epithelial cells of adenocarcinoma frequently showed a decrease in high and a fall off into the lumen in tumor invasive forefront. Immunohistochemically the positive rate of p53 and c-erb B-2 in tumors with high vascular invasion were higher (p< 0.05) than in those with low vascular invasion. There was a close correlation between the vascular or lymphatic invasion and positive immunoreactivity of p53 and c-erb B-2. The apoptosis index was demonstrated to be related to vessel invasion, over expression of p53 and inflammatory cell infiltration around the front portion of the tumor invasion. These results suggested that p53, c-erb B-2 and the apoptosis index should be evaluated in conjunction with the prognostic factors in colorectal cancer. The infiltrative inflammatory cells may induce apoptosis of the tumor cells.
Correspondence to	Qun He, Department of Pathology, Nippon Medical School, Chiba Hokusou Hospital, 1715 Kamakari Inba-mura, Inba-gun, Chiba 270-1694, Japan