Journal of Nippon Medical School: Vol.66 No.4 page.262

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ArticleTitle Repeated propofol anesthesia for a patient with a history of neuroleptic malignant syndrome

AuthorList Atsuhiro Sakamoto¹⁾ , Takeshi Hoshino¹⁾ , Hiroko Suzuki²⁾ , Mahito Kimura²⁾ and Ryo Ogawa¹⁾

Affiliation ¹⁾ Department of Anesthesiology and ²⁾ Department of Neuropsychiatry, Nippon Medical School

Language EN

Volume 66

Issue 4

Year 1999

Page 262-265

Received March 23, 1999

Accepted April 14, 1999

Keywords propofol, neuroleptic malignant syndrome, malignant hyperthermia

Abstract Neuroleptic malignant syndrome (NMS) is the most serious side effect produced by the administration of antipsychotic drugs. NMS shares many clinical similarities with malignant hyperthermia (MH), but the etiology of NMS and the relation between NMS and MH remain unknown. Anesthetic regimens for patients with NMS are not well established. We gave repeated anesthesia to a patient with a history of NMS undergoing electroconvulsive therapy for the treatment of depression. Propofol and vecuronium were used in twelve consecutive ECT sessions without complications. In this case report, we describe the safe and satisfactory repeated use of propofol in a patient with a history of NMS, and outline NMS and its questionable relation to MH.

Correspondence to Atsuhiro Sakamoto, Department of Anesthesiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

ArticleTitle	Repeated propofol anesthesia for a patient with a history of neuroleptic malignant syndrome
AuthorList	Atsuhiro Sakamoto¹⁾ , Takeshi Hoshino¹⁾ , Hiroko Suzuki²⁾ , Mahito Kimura²⁾ and Ryo Ogawa¹⁾
Affiliation	¹⁾ Department of Anesthesiology and ²⁾ Department of Neuropsychiatry, Nippon Medical School
Language	EN
Volume	66
Issue	4
Year	1999
Page	262-265
Received	March 23, 1999
Accepted	April 14, 1999
Keywords	propofol, neuroleptic malignant syndrome, malignant hyperthermia
Abstract	Neuroleptic malignant syndrome (NMS) is the most serious side effect produced by the administration of antipsychotic drugs. NMS shares many clinical similarities with malignant hyperthermia (MH), but the etiology of NMS and the relation between NMS and MH remain unknown. Anesthetic regimens for patients with NMS are not well established. We gave repeated anesthesia to a patient with a history of NMS undergoing electroconvulsive therapy for the treatment of depression. Propofol and vecuronium were used in twelve consecutive ECT sessions without complications. In this case report, we describe the safe and satisfactory repeated use of propofol in a patient with a history of NMS, and outline NMS and its questionable relation to MH.
Correspondence to	Atsuhiro Sakamoto, Department of Anesthesiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan