Journal of Nippon Medical School: Vol.66 No.5 page.308

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ArticleTitle Elimination of non-ionic contrast medium by hemodialysis in patients with impaired renal function

AuthorList Kazutaka Horiuchi¹⁾ , Kazuhiro Yoshida¹⁾ , Narumi Tsuboi¹⁾ , Masao Akimoto¹⁾ , Hiroyuki Tajima²⁾ , Tatsuo Kumazaki²⁾

Affiliation ¹⁾ Department of Urology and ²⁾ Department of Radiology, Nippon Medical School

Language EN

Volume 66

Issue 5

Year 1999

Page 305-307

Received July 19, 1999

Accepted August 13, 1999

Keywords hemodialysis, elimination, non-ionic contrast medium, renal dysfunction

Abstract The elimination rate of iohexol, a non-ionic contrast medium, from the blood by hemodialysis, and the elimination rate of iohexol by a dialyzer were studied in 15 patients with chronic renal dysfunction who required angiography or enhanced CT. The elimination rate of iohexol was 19.8%at 15 min after the start of hemodialysis, 30.6%after 30 min, 44.2%after 1 hour, 62.1%after 2 hours and 72.9%after 3 hours. The dialyzer elimination rate was maintained at about 75%from 1 to 3 hours after the start of hemodialysis. If only about 70%of iohexol in the blood needs to be eliminated, hemodialysis for 3 hours with a blood flow rate of 120 ml/min and a dialysate flow of 500 ml/min using a 0.7 m² cellulose triacetate membrane is sufficient.

Correspondence to Kazutaka Horiuchi, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.

ArticleTitle	Elimination of non-ionic contrast medium by hemodialysis in patients with impaired renal function
AuthorList	Kazutaka Horiuchi¹⁾ , Kazuhiro Yoshida¹⁾ , Narumi Tsuboi¹⁾ , Masao Akimoto¹⁾ , Hiroyuki Tajima²⁾ , Tatsuo Kumazaki²⁾
Affiliation	¹⁾ Department of Urology and ²⁾ Department of Radiology, Nippon Medical School
Language	EN
Volume	66
Issue	5
Year	1999
Page	305-307
Received	July 19, 1999
Accepted	August 13, 1999
Keywords	hemodialysis, elimination, non-ionic contrast medium, renal dysfunction
Abstract	The elimination rate of iohexol, a non-ionic contrast medium, from the blood by hemodialysis, and the elimination rate of iohexol by a dialyzer were studied in 15 patients with chronic renal dysfunction who required angiography or enhanced CT. The elimination rate of iohexol was 19.8%at 15 min after the start of hemodialysis, 30.6%after 30 min, 44.2%after 1 hour, 62.1%after 2 hours and 72.9%after 3 hours. The dialyzer elimination rate was maintained at about 75%from 1 to 3 hours after the start of hemodialysis. If only about 70%of iohexol in the blood needs to be eliminated, hemodialysis for 3 hours with a blood flow rate of 120 ml/min and a dialysate flow of 500 ml/min using a 0.7 m² cellulose triacetate membrane is sufficient.
Correspondence to	Kazutaka Horiuchi, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.