Journal of Nippon Medical School: Vol.67 No.1 page.028

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ArticleTitle Evaluation of prognostic factors and PCNA expression for pulmonary metastatic tumors of colorectal carcinoma

AuthorList Shinji Matsushima¹, Hideki Yamamoto¹, Seiji Suzuki¹, Kaku Egami¹, Masatomo Yoshioka¹, Nobutaka Yamada² and Shigeo Tanaka³

Affiliation ¹Department of Surgery of TamaNagayama Hospital, Nippon Medical School²2nd Department of Pathology and ³2nd Department of Surgery, Nippon Medical School

Language EN

Volume 67

Issue 1

Year 2000

Page 28-31

Received August 19, 1999

Accepted October 15, 1999

Keywords pulmonary metastatic tumor, colorectal carcinoma, PCNA, prognostic factor

Abstract The present study was conducted to evaluate clinicopathologically 26 patients whose primary colorectal carcinoma and resulting pulmonary metastatic tumors had been resected, and to determine the relationship between tumor progress and prognosis by PCNA immunostaining. Patients with solitary pulmonary metastasis were found to have much better prognoses than those with multiple metastasis. There was no correlation between tumor size of pulmonary metastasis and prognosis. Survival rates of patients with disease-free intervals (DFIs) of 2 years or longer were higher than for those with DFIs of less than 2 years. Mean PCNA expression of pulmonary metastatic lesions was significantly higher than that of primary lesions. It was suggested that the higher PCNA expression stemming from the relation between depth of tumor invasion and PCNA expression was greater with tumor progress.

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ArticleTitle	Evaluation of prognostic factors and PCNA expression for pulmonary metastatic tumors of colorectal carcinoma
AuthorList	Shinji Matsushima¹, Hideki Yamamoto¹, Seiji Suzuki¹, Kaku Egami¹, Masatomo Yoshioka¹, Nobutaka Yamada² and Shigeo Tanaka³
Affiliation	¹Department of Surgery of TamaNagayama Hospital, Nippon Medical School²2nd Department of Pathology and ³2nd Department of Surgery, Nippon Medical School
Language	EN
Volume	67
Issue	1
Year	2000
Page	28-31
Received	August 19, 1999
Accepted	October 15, 1999
Keywords	pulmonary metastatic tumor, colorectal carcinoma, PCNA, prognostic factor
Abstract	The present study was conducted to evaluate clinicopathologically 26 patients whose primary colorectal carcinoma and resulting pulmonary metastatic tumors had been resected, and to determine the relationship between tumor progress and prognosis by PCNA immunostaining. Patients with solitary pulmonary metastasis were found to have much better prognoses than those with multiple metastasis. There was no correlation between tumor size of pulmonary metastasis and prognosis. Survival rates of patients with disease-free intervals (DFIs) of 2 years or longer were higher than for those with DFIs of less than 2 years. Mean PCNA expression of pulmonary metastatic lesions was significantly higher than that of primary lesions. It was suggested that the higher PCNA expression stemming from the relation between depth of tumor invasion and PCNA expression was greater with tumor progress.
Correspondence to