Journal of Nippon Medical School: Vol.67 No.4 page.242

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ArticleTitle Proliferating Cell Nuclear Antigen and p53 Protein Expression in Submucosal Invasive Colorectal Carcinoma

AuthorList Yoshikazu Kanazawa, Masahiko Onda, Noritake Tanaka and Tomoko Seya

Affiliation First Department of Surgery, Nippon Medical School

Language JA

Volume 67

Issue 4

Year 2000

Page 242-249

Received April 6, 2000

Accepted May 11, 2000

Keywords submucosal invasive carcinoma, proliferating cell nuclear antigen (PCNA), p53 protein, immunohistochemistry

Abstract In some cases of early colorectal carcinoma, radical surgical resection might be required because of vessel invasion, distant metastasis, or inadequate surgical margin. To characterize submucosal invasive colorectal carcinoma, we investigated expression of PCNA and p53 protein. Sixty-seven patients who underwent curative resection of submucosal invasive colorectal carcinoma participated in this study. The PCNA labeling index (PCNA-LI) is determined at the deepest lesion of carcinoma. The expression of PCNA and p53 protein were analyzed according to clinicopathological factors. 1) The PCNA-LI was correlated to histological grade, depth of invasion or vessel invasion in polypoid type. 2) The flat type had significantly higher PCNA-LI (65.1 ± 8.2%) and p53 protein expression (69.6%) than the polypoid type. 3) The PCNA-LI was higher in cases with lymph node metastasis than in these without lymph node metastasis. 4) Overexpression of the p53 protein was detected in all cases with liver metastasis. Our results suggest that in order to determine the treatment for the patients with submucosal invasive colorectal carcinoma, the expression of PCNA and p53 protein may be a useful biologic marker.

Correspondence to Yoshikazu Kanazawa, First Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

ArticleTitle	Proliferating Cell Nuclear Antigen and p53 Protein Expression in Submucosal Invasive Colorectal Carcinoma
AuthorList	Yoshikazu Kanazawa, Masahiko Onda, Noritake Tanaka and Tomoko Seya
Affiliation	First Department of Surgery, Nippon Medical School
Language	JA
Volume	67
Issue	4
Year	2000
Page	242-249
Received	April 6, 2000
Accepted	May 11, 2000
Keywords	submucosal invasive carcinoma, proliferating cell nuclear antigen (PCNA), p53 protein, immunohistochemistry
Abstract	In some cases of early colorectal carcinoma, radical surgical resection might be required because of vessel invasion, distant metastasis, or inadequate surgical margin. To characterize submucosal invasive colorectal carcinoma, we investigated expression of PCNA and p53 protein. Sixty-seven patients who underwent curative resection of submucosal invasive colorectal carcinoma participated in this study. The PCNA labeling index (PCNA-LI) is determined at the deepest lesion of carcinoma. The expression of PCNA and p53 protein were analyzed according to clinicopathological factors. 1) The PCNA-LI was correlated to histological grade, depth of invasion or vessel invasion in polypoid type. 2) The flat type had significantly higher PCNA-LI (65.1 ± 8.2%) and p53 protein expression (69.6%) than the polypoid type. 3) The PCNA-LI was higher in cases with lymph node metastasis than in these without lymph node metastasis. 4) Overexpression of the p53 protein was detected in all cases with liver metastasis. Our results suggest that in order to determine the treatment for the patients with submucosal invasive colorectal carcinoma, the expression of PCNA and p53 protein may be a useful biologic marker.
Correspondence to	Yoshikazu Kanazawa, First Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan