Journal of Nippon Medical School: Vol.67 No.6 page.421

Journal of Nippon Medical School

Select Language
in Japanese < > in English

Full Text of this Article

in English PDF (403k)

ArticleTitle Sequential Gadolinium-Enhanced Magnetic Resonance Angiography of the Aortoiliac and the Femoropopliteal Arteries with Repetitive Administration of Low-Dose Contrast Agent

AuthorList Koichiro Ito¹ and Tatsuo Kumazaki²

Affiliation ¹ Department of Radiology, Nippon Medical School, Chiba Hokusoh Hospital ² Department of Radiology, Nippon Medical School

Language EN

Volume 67

Issue 6

Year 2000

Page 421-428

Received February 16, 2000

Accepted July 7, 2000

Keywords magnetic resonance angiography (MRA), contrast enhance, gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA), distal arteries

Abstract To obtain a wide-range contrast MR angiography in a single examination, we performed two sequential administrations of low-dose (0.08 mmol/kg) gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) with three dimensional inversion recovery prepared fast spoiled gradient recalled acquisition in the steady-state (3D IR-fast SPGR) sequence.
Signal characteristics of the sequence were estimated by computed simulations and an in vitro study. A clinical study of 19 examinations was done with sequential MR angiography of the aortoiliac and femoropopliteal arteries.
Great signal differences were observed between the high and low Gd concentrations. Higher Gd concentrations generated significantly stronger signals. Greater signals were produced at TIs of longer than 150 msec than at shorter than 100 msec.
In the clinical study, the arteries were visualized with sufficient signals even with a small amount of contrast agent. Contrast-to-noise ratios between the arteries and surrounding skeletal muscles or fat tissues ranged from 10.5±9.6 to 4.7±2.2 and 6.6±2.8 to-3.1±11.2, respectively. No venous enhancement was found with diluted contrast agent on the second MR angiography.
Two consecutive contrast MR angiographies can be obtained with repetitive administration of low-dose contrast agent.

Correspondence to Koichiro Ito, Department of Radiology, Chiba Hokusoh Hospital, Nippon Medical School, 1715 Kamakari, Inba-mura, Inba-gun, Chiba 270-1613, Japan

ArticleTitle	Sequential Gadolinium-Enhanced Magnetic Resonance Angiography of the Aortoiliac and the Femoropopliteal Arteries with Repetitive Administration of Low-Dose Contrast Agent
AuthorList	Koichiro Ito¹ and Tatsuo Kumazaki²
Affiliation	¹ Department of Radiology, Nippon Medical School, Chiba Hokusoh Hospital ² Department of Radiology, Nippon Medical School
Language	EN
Volume	67
Issue	6
Year	2000
Page	421-428
Received	February 16, 2000
Accepted	July 7, 2000
Keywords	magnetic resonance angiography (MRA), contrast enhance, gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA), distal arteries
Abstract	To obtain a wide-range contrast MR angiography in a single examination, we performed two sequential administrations of low-dose (0.08 mmol/kg) gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) with three dimensional inversion recovery prepared fast spoiled gradient recalled acquisition in the steady-state (3D IR-fast SPGR) sequence. Signal characteristics of the sequence were estimated by computed simulations and an in vitro study. A clinical study of 19 examinations was done with sequential MR angiography of the aortoiliac and femoropopliteal arteries. Great signal differences were observed between the high and low Gd concentrations. Higher Gd concentrations generated significantly stronger signals. Greater signals were produced at TIs of longer than 150 msec than at shorter than 100 msec. In the clinical study, the arteries were visualized with sufficient signals even with a small amount of contrast agent. Contrast-to-noise ratios between the arteries and surrounding skeletal muscles or fat tissues ranged from 10.5±9.6 to 4.7±2.2 and 6.6±2.8 to-3.1±11.2, respectively. No venous enhancement was found with diluted contrast agent on the second MR angiography. Two consecutive contrast MR angiographies can be obtained with repetitive administration of low-dose contrast agent.
Correspondence to	Koichiro Ito, Department of Radiology, Chiba Hokusoh Hospital, Nippon Medical School, 1715 Kamakari, Inba-mura, Inba-gun, Chiba 270-1613, Japan