Journal of Nippon Medical School: Vol.67 No.6 page.434

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ArticleTitle Changes in Maternal Lipid Peroxidation Levels and Antioxidant Enzymatic Activities Before and After Delivery

AuthorList Akihito Nakai, Atsuko Oya, Hitoshi Kobe, Hirobumi Asakura, Akishige Yokota, Tatsuo Koshino and Tsutomu Araki

Affiliation Department of Obstetrics and Gynecology, Nippon Medical School

Language EN

Volume 67

Issue 6

Year 2000

Page 434-439

Received June 16, 2000

Accepted July 18, 2000

Keywords maternal, lipid peroxidation, antioxidant enzymatic activities, delivery

Abstract Objective: Our goal was to characterize the changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery.
Methods: Predelivery and 1, 24, and 48 hours post-partum plasma concentrations of malondialdehyde, erythrocyte enzyme superoxide dismutase, glutathione peroxidase and catalase were measured in uncomplicated pregnancies.
Results: Malondialdehyde levels increased slightly from predelivery to 24 hours post-partum and then decreased significantly at 48 hours post-partum. At one hour post-partum superoxide dismutase and catalase levels increased significantly to about 125% and 170% of predelivery levels, respectively. Thereafter, these values decreased significantly from one hour to 48 hours post-partum. The relative changes in superoxide dismutase and catalase levels at one hour post-partum compared to predelivery values correlated significantly with the duration of labor.
Conclusion: The results suggest that the uncontrolled lipid peroxidation caused by reactive oxygen species, which are produced in consequence of tissue reoxygenation, may occur during labor and that prolonged labor, may cause maternal oxidative stress.

Correspondence to Akihito Nakai MD, Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama-shi, Tokyo, 206-8512, Japan
Nakai_Akihito/obgy@nms.ac.jp

ArticleTitle	Changes in Maternal Lipid Peroxidation Levels and Antioxidant Enzymatic Activities Before and After Delivery
AuthorList	Akihito Nakai, Atsuko Oya, Hitoshi Kobe, Hirobumi Asakura, Akishige Yokota, Tatsuo Koshino and Tsutomu Araki
Affiliation	Department of Obstetrics and Gynecology, Nippon Medical School
Language	EN
Volume	67
Issue	6
Year	2000
Page	434-439
Received	June 16, 2000
Accepted	July 18, 2000
Keywords	maternal, lipid peroxidation, antioxidant enzymatic activities, delivery
Abstract	Objective: Our goal was to characterize the changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery. Methods: Predelivery and 1, 24, and 48 hours post-partum plasma concentrations of malondialdehyde, erythrocyte enzyme superoxide dismutase, glutathione peroxidase and catalase were measured in uncomplicated pregnancies. Results: Malondialdehyde levels increased slightly from predelivery to 24 hours post-partum and then decreased significantly at 48 hours post-partum. At one hour post-partum superoxide dismutase and catalase levels increased significantly to about 125% and 170% of predelivery levels, respectively. Thereafter, these values decreased significantly from one hour to 48 hours post-partum. The relative changes in superoxide dismutase and catalase levels at one hour post-partum compared to predelivery values correlated significantly with the duration of labor. Conclusion: The results suggest that the uncontrolled lipid peroxidation caused by reactive oxygen species, which are produced in consequence of tissue reoxygenation, may occur during labor and that prolonged labor, may cause maternal oxidative stress.
Correspondence to	Akihito Nakai MD, Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama-shi, Tokyo, 206-8512, Japan Nakai_Akihito/obgy@nms.ac.jp