Journal of Nippon Medical School: Vol.68 No.1 page.037

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ArticleTitle Localization of Extracellular Matrix and Mitogen-Activated Protein Kinase (MAPK) in Aorta of Streptozotocin Treated Mongolian Gerbils

AuthorList Zenya Naito¹, Ryutaro Nishigaki¹, Kiyoko Kawahara¹, Munehiro Yokoyama¹, Nobutaka Yamada¹, Goro Asano¹, Masumi Shimizu-Suganuma² and Kazuhiro Shichinohe²

Affiliation ¹Department of Pathology, ²Department of Laboratory Animal Science, Nippon Medical School

Language EN

Volume 68

Issue 1

Year 2001

Page 37-44

Received June 5, 2000

Accepted August 31, 2000

Keywords fibronectin, laminin, mitogen-activated protein kinase (MAPK), macrovasculopathy, Mongolian gerbil

Abstract To evaluate the relationship among the extracellular matrix (ECM) and mitogen-activated protein kinase (MAPK) family for the vascular damages in hyperglycemia, we injected Mongolian gerbils intravenously with 150 mg/kg streptozotocin (STZ) and observed over the next one year the resulting aortic changes by immunohistochemical techniques.
After STZ treatment, hyperglycemia was confirmed. At 4 weeks after STZ administration morphological observation revealed increased stromal components among the vascular smooth muscle cells (SMCs). Immunohistochemically, extracellular matrices such as fibronectin and laminin were localized in the aorta at 4 weeks and one year after STZ administration. The reaction products of MAPK in vascular SMCs were more increased at one year than at 4 weeks after STZ administration.
After STZ administration, the increase of ECM and MAPK was observed in the aorta, which suggests these factors play important roles in the pathogenesis of macrovasculopathy in diabetes mellitus.

Correspondence to Zenya Naito, Department of Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

ArticleTitle	Localization of Extracellular Matrix and Mitogen-Activated Protein Kinase (MAPK) in Aorta of Streptozotocin Treated Mongolian Gerbils
AuthorList	Zenya Naito¹, Ryutaro Nishigaki¹, Kiyoko Kawahara¹, Munehiro Yokoyama¹, Nobutaka Yamada¹, Goro Asano¹, Masumi Shimizu-Suganuma² and Kazuhiro Shichinohe²
Affiliation	¹Department of Pathology, ²Department of Laboratory Animal Science, Nippon Medical School
Language	EN
Volume	68
Issue	1
Year	2001
Page	37-44
Received	June 5, 2000
Accepted	August 31, 2000
Keywords	fibronectin, laminin, mitogen-activated protein kinase (MAPK), macrovasculopathy, Mongolian gerbil
Abstract	To evaluate the relationship among the extracellular matrix (ECM) and mitogen-activated protein kinase (MAPK) family for the vascular damages in hyperglycemia, we injected Mongolian gerbils intravenously with 150 mg/kg streptozotocin (STZ) and observed over the next one year the resulting aortic changes by immunohistochemical techniques. After STZ treatment, hyperglycemia was confirmed. At 4 weeks after STZ administration morphological observation revealed increased stromal components among the vascular smooth muscle cells (SMCs). Immunohistochemically, extracellular matrices such as fibronectin and laminin were localized in the aorta at 4 weeks and one year after STZ administration. The reaction products of MAPK in vascular SMCs were more increased at one year than at 4 weeks after STZ administration. After STZ administration, the increase of ECM and MAPK was observed in the aorta, which suggests these factors play important roles in the pathogenesis of macrovasculopathy in diabetes mellitus.
Correspondence to	Zenya Naito, Department of Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan