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ArticleTitle	Abnormalities of the p53, N-ras, DCC and FLT-3 Genes in Myelodysplastic Syndromes
AuthorList	Kayo Nakamura, Koiti Inokuchi and Kazuo Dan
Affiliation	Department of 3rd Internal Medicine, Nippon Medical School
Language	JA
Volume	68
Issue	2
Year	2001
Page	143-148
Received	August 2, 2000
Accepted	September 13, 2000
Keywords	myelodysplastic syndromes, p53, N-ras, DCC, FLT-3
Abstract	The molecular mechanism of carcinogenesis is a multistep process that is characterized by both activation of oncogenes and inactivation of tumor suppressor genes. In the present study, mutations of N-ras, p53 and FMS-like tyrosine kinase 3 (FLT-3) genes and loss of expression of the deleted in colorectal carcinoma (DCC) gene were analyzed in 59 patients with myelodysplastic syndromes (MDS). Mutations of N-ras, p53, and FLT-3 genes were detected in 7, 7, 1 of the 59 patients with MDS, respectively. Loss of DCC expression was detected in 16 patients. Type of MDS patients with N-ras mutation were all refractory anemia with excess of blasts in transformation (RAEB-T). Abnormalities of p53 and DCC genes were significantly associated with survival time (p< 0.02, p< 0.004, respectively).
Correspondence to	Koiti Inokuchi, Department of 3rd Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan