Journal of Nippon Medical School: Vol.68 No.2 page.181

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ArticleTitle The Short-Term Effects of Terazosin in Japanese Men with Benign Prostatic Hyperplasia

AuthorList Kazutaka Horiuchi, Narumi Tsuboi, Yasutomo Suzuki, Kazuhiro Yoshida and Masao Akimoto

Affiliation Department of Urology, Nippon Medical School

Language EN

Volume 68

Issue 2

Year 2001

Page 181-185

Received September 22, 2000

Accepted December 7, 2000

Keywords prostate, benign prostatic hyperplasia, clinical effect, terazosin

Abstract We evaluated the short-term efficacy of terazosin for treating symptomatic benign prostatic hyperplasia (BPH). Thirty men, aged 52 to 83 years (mean: 69.2 years) complaining of obstructive urinary symptoms due to BPH who had not received any prior treatment for their symptoms were orally administered 2 mg/day of terazosin. Symptoms (the total IPSS and the obstructive and irritative symptom scores) and objective parameters (peak flow rate [Qmax] and prostatic volume) were evaluated before treatment and after 1, 2, and 4 weeks of treatment. The mean total IPSS and the mean symptom scores for weak stream and nocturia were significantly decreased after only 1 week of treatment, while the mean scores for emptying, frequency, and urgency were significantly decreased after 2 weeks of treatment. However, the mean scores for intermittency and hesitancy did not decrease significantly at any time during treatment. Regarding objective parameters, the mean Qmax was significantly improved after 1 week of treatment, but the mean prostatic volume remained almost unchanged after 4 weeks. In conclusion, short-term terazosin therapy not only improved Qmax but also alleviated symptoms including irritative symptoms.

Correspondence to Kazutaka Horiuchi, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

ArticleTitle	The Short-Term Effects of Terazosin in Japanese Men with Benign Prostatic Hyperplasia
AuthorList	Kazutaka Horiuchi, Narumi Tsuboi, Yasutomo Suzuki, Kazuhiro Yoshida and Masao Akimoto
Affiliation	Department of Urology, Nippon Medical School
Language	EN
Volume	68
Issue	2
Year	2001
Page	181-185
Received	September 22, 2000
Accepted	December 7, 2000
Keywords	prostate, benign prostatic hyperplasia, clinical effect, terazosin
Abstract	We evaluated the short-term efficacy of terazosin for treating symptomatic benign prostatic hyperplasia (BPH). Thirty men, aged 52 to 83 years (mean: 69.2 years) complaining of obstructive urinary symptoms due to BPH who had not received any prior treatment for their symptoms were orally administered 2 mg/day of terazosin. Symptoms (the total IPSS and the obstructive and irritative symptom scores) and objective parameters (peak flow rate [Qmax] and prostatic volume) were evaluated before treatment and after 1, 2, and 4 weeks of treatment. The mean total IPSS and the mean symptom scores for weak stream and nocturia were significantly decreased after only 1 week of treatment, while the mean scores for emptying, frequency, and urgency were significantly decreased after 2 weeks of treatment. However, the mean scores for intermittency and hesitancy did not decrease significantly at any time during treatment. Regarding objective parameters, the mean Qmax was significantly improved after 1 week of treatment, but the mean prostatic volume remained almost unchanged after 4 weeks. In conclusion, short-term terazosin therapy not only improved Qmax but also alleviated symptoms including irritative symptoms.
Correspondence to	Kazutaka Horiuchi, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan