Home > List of Issue > Table of Contents > Abstract

ArticleTitle	Hemorrhagic Gastric Carcinoma in an Acromegalic Patient
AuthorList	Hirokazu Hasegawa1, Masahiko Onda1, Norio Matsukura1, Zenya Naito2, Hiroshi Maruyama1 and Akira Tokunaga1
Affiliation	1First Department of Surgery and 2Second Department of Pathology, Nippon Medical School, Tokyo.
Language	EN
Volume	68
Issue	3
Year	2001
Page	266-270
Received	December 25, 2000
Accepted	January 16, 2001
Keywords	acromegaly, gastric cancer, growth hormone, insulin-like growth factor I, Helicobacter pylori
Abstract	A rare case of hemorrhagic gastric carcinoma in an acromegalic patient is reported. A 79-year-old Japanese man was referred to our hospital with diagnoses of upper gastrointestinal hemorrhage and angina pectoris. This patient showed typical clinical features of acromegaly, with increased serum growth hormone (GH) and insulin-like growth factor I (IGF-I) level. A high titer of serum anti-Helicobacter pylori (H. pylori) IgG was also observed. After percutaneous transluminal coronary angioplasty treatment for stenosis of the right coronary artery, the patient underwent distal gastrectomy. Gastric cancer was Type 2 macroscopically and was diagnosed histologically as a papillary and well to moderately differentiated tubular adenocarcinoma. Reverse transcription-polymerase chain reaction analysis estimated that the amount of IGF-I receptor mRNA expression in the gastric cancer tissue was 1.6 times higher than that in the adjacent atrophic mucosa, whereas the amount of IGF-I mRNA expression in the cancer tissue was only half that in the atrophic mucosa. Both the stimulatory effects of GH and/or IGF-I on cell proliferation and H. pylori infection in gastric tumorigenesis may have been responsible for the development and growth of gastric carcinoma in this patient.
Correspondence to	Hirokazu Hasegawa, MD, First Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan kazunn@nms.ac.jp