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ArticleTitle	Asymptomatic Pyuria in Diabetic Women
AuthorList	Hiroshi Nakano, Kenzo Oba, Yoshichika Saito, Motoshi Ouchi, Naoko Yamashita, Kojiro Okamura, Emiko Takai, Shigeyoshi Mizuno, Noriaki Matsumura, Yuki Inuzuka and Tatsuya Suzuki
Affiliation	Division of Geriatric Medicine, Nippon Medical School
Language	EN
Volume	68
Issue	5
Year	2001
Page	405-410
Received	February 22, 2001
Accepted	April 27, 2001
Keywords	asymptomatic pyuria, type 2 diabetes, duration of diabetes, diabetic microangiopathy, glucose control
Abstract	The aim of the present study was to determine the prevalence of and the host factors for asymptomatic pyuria (ASP) in women with type 2 diabetes. The study included 179 type 2 diabetic women and consecutive 455 non-diabetic women attending as out-patients in 1996. Patients with symptoms of a urinary tract infection were excluded. ASP was defined as the presence of more than 10 leukocytes/high-power field in a random urine sample. Diabetic women more often had ASP than non-diabetic women (27.9 vs. 15.8%, P<0.001). The prevalence of ASP was significantly increased in patients with a duration of diabetes exceeding 15 years (0∼4 years; 20.3%, 5∼9 years; 24.3%, 10∼14 years; 23.8%, and≥15 years; 46.3%). No differences were evident in HbA1C between diabetic patients without ASP and those with ASP. Diabetic women with ASP more often had diabetic retinopathy, neuropathy, nephropathy, cerebrovascular disease, ischemic heart disease, and hyperlipidemia than those witout ASP. However, no statistically significant differences were evident in the prevalence of hypertension, constipation, or dementia. As the degree of neuropathy increases, it is accompanied by an increasing prevalence of ASP (none, 21.4%; blunt tendon reflexes, 24.5%; symptomatic, 50.0%; and gangrene, 66.6%). The prevalence of ASP was significantly increased in the patients with proliferative diabetic retinopathy (none, 23.2%; background, 29.4%; preproliferative, 18.2%; and proliferative, 50.0%). As the degree of nephropathy increases, it is accompanied by an increasing prevalence of ASP (none, 20.0%; microalbuminuria, 31.9%; macroalbuminuria, 37.0%; and renal failure, 60.0%). Thus, the prevalence of ASP is increased in women with diabetes and increased with longer duration of diabetes but was not affected by glucose control. The incidence of ASP increases significantly as diabetic microangiopathy becomes severer.
Correspondence to	Hiroshi Nakano, MD, Division of Geriatric Medicine, Nippon Medial School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan nakano@nms.ac.jp