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ArticleTitle	CD1: A New Paradigm for Antigen Presentation
AuthorList	Masahiko Sugita
Affiliation	Department of Microbiology and Immunology, Nippon Medical School
Language	JA
Volume	68
Issue	6
Year	2001
Page	466-471
Received	October 1, 2001
Accepted	October 9, 2001
Keywords	CD1, MHC, lipid antigen, mycobacteria, dendritic cells
Abstract	Molecules of the major histocompatibility complex (MHC) bind protein-derived peptide antigens and present them to T cells. This has been a central dogma in modern immunology, and our appreciation of a variety of cell-mediated immune responses has been based only on this paradigm. However, we now know that T cell recognition also involves non-peptide antigens. Studies over the past several years have established a new paradigm that non-MHC-encoded molecules of the CD1 family mediate presentation of lipid antigens to T cells, and unraveled their significant role in microbial immunity, tumor immunology, and autoimmunity. Identification of a novel pathway for T cell activation mediated by CD1 molecules opens a possiblity for new therapeutic strategies, including development of lipid-based vaccines.
Correspondence to	Masahiko Sugita, MD, PhD, Department of Microbiology and I mmunology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan msugita@nms.ac.jp