Journal of Nippon Medical School: Vol.69 No.1 page.031

Journal of Nippon Medical School

Select Language
in Japanese < > in English

Full Text of this Article

in English PDF (96k)

ArticleTitle Relation of Apolipoprotein (a) Phenotypes to Diabetic Retinopathy in Elderly Type 2 Diabetes

AuthorList Tatsuya Suzuki, Kenzo Oba, Yoshimasa Igari, Noriaki Matsumura, Yuki Inuzuka, Yoshiaki Kigawa, Yoshiki Matsuura, Yumiko Ajiro, Kyoji Okazaki and Hiroshi Nakano

Affiliation Division of Geriatric Medicine, Nippon Medical School

Language EN

Volume 69

Issue 1

Year 2002

Page 31-38

Received May 15, 2001

Accepted August 22, 2001

Keywords lipoprotein (a), apolipoprotein (a) phenotypes, diabetic retinopathy, type 2 diabetes mellitus, elderly

Abstract The aim of this study was to clarify the relationship between apolipoprotein (a) (apo (a) ) phenotypes and diabetic retinopathy in elderly type 2 diabetes. Serum Lp (a) concentrations and apo (a) phenotypes were analyzed in 250 diabetic patients aged 60 to 88 years old. Apo (a) phenotypes were classified into 7 subtypes (F, B, S1, S2, S3, S4, O (Null) ) by the method SDS electrophoresis with Western blotting. Patients were divided into two groups according to their apo (a) phenotypes:a low molecular weight (LMW) Lp (a) group, and a high molecular weight (HML) Lp (a) group. Patients were classified as having one of 4 types of diabetic retinopathy: no retinopathy (R0), simple retinopathy (R1), pre-proliferative retinopathy (R2), and proliferative retinopathy (R3). There was a significant association between serum Lp (a) levels and severity of diabetic retinopathy (p<0.001). A gradual trend toward increasing serum Lp (a) levels was observed across the groups (from R0 to R3). A significantly greater percentage of LMW Lp (a) was observed in the R1, R2, and R3 groups than in the R0 group (42.9% (p<0.001), 27.0% (p<0.01), and 27.3% (p<0.05) vs. 10.4%). Multiple logistic regression analysis revealed that duration of diabetes and LMW Lp (a) are independent risk factors for diabetic retinopathy. These results provide significant evidence that LMW Lp (a) contributes to an increased risk of diabetic retinopathy in elderly type 2 diabetes.

Correspondence to Tatsuya Suzuki, MD, Division of Geriatric Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

ArticleTitle	Relation of Apolipoprotein (a) Phenotypes to Diabetic Retinopathy in Elderly Type 2 Diabetes
AuthorList	Tatsuya Suzuki, Kenzo Oba, Yoshimasa Igari, Noriaki Matsumura, Yuki Inuzuka, Yoshiaki Kigawa, Yoshiki Matsuura, Yumiko Ajiro, Kyoji Okazaki and Hiroshi Nakano
Affiliation	Division of Geriatric Medicine, Nippon Medical School
Language	EN
Volume	69
Issue	1
Year	2002
Page	31-38
Received	May 15, 2001
Accepted	August 22, 2001
Keywords	lipoprotein (a), apolipoprotein (a) phenotypes, diabetic retinopathy, type 2 diabetes mellitus, elderly
Abstract	The aim of this study was to clarify the relationship between apolipoprotein (a) (apo (a) ) phenotypes and diabetic retinopathy in elderly type 2 diabetes. Serum Lp (a) concentrations and apo (a) phenotypes were analyzed in 250 diabetic patients aged 60 to 88 years old. Apo (a) phenotypes were classified into 7 subtypes (F, B, S1, S2, S3, S4, O (Null) ) by the method SDS electrophoresis with Western blotting. Patients were divided into two groups according to their apo (a) phenotypes:a low molecular weight (LMW) Lp (a) group, and a high molecular weight (HML) Lp (a) group. Patients were classified as having one of 4 types of diabetic retinopathy: no retinopathy (R0), simple retinopathy (R1), pre-proliferative retinopathy (R2), and proliferative retinopathy (R3). There was a significant association between serum Lp (a) levels and severity of diabetic retinopathy (p<0.001). A gradual trend toward increasing serum Lp (a) levels was observed across the groups (from R0 to R3). A significantly greater percentage of LMW Lp (a) was observed in the R1, R2, and R3 groups than in the R0 group (42.9% (p<0.001), 27.0% (p<0.01), and 27.3% (p<0.05) vs. 10.4%). Multiple logistic regression analysis revealed that duration of diabetes and LMW Lp (a) are independent risk factors for diabetic retinopathy. These results provide significant evidence that LMW Lp (a) contributes to an increased risk of diabetic retinopathy in elderly type 2 diabetes.
Correspondence to	Tatsuya Suzuki, MD, Division of Geriatric Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan