Journal of Nippon Medical School: Vol.69 No.1 page.053

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ArticleTitle Effect of Maclorides on Duration and Resolution of Symptoms and Complication of Pneumonia in Children with Influenza

AuthorList Keiko Ninomiya¹, Tomoko Fukui², Toshiko Imai², Motoyo Matsui² and Kazuhiko Matsuoka¹

Affiliation ¹Department of Pediatrics, Nissan Tamagawa Hospital, ²Department of Pediatrics Nippon Medical School

Language EN

Volume 69

Issue 1

Year 2002

Page 53-57

Received September 17, 2001

Accepted October 17, 2001

Keywords influenza, pneumonia, macrolides, cepharosporins

Abstract We randomly administered cephalosporins or macrolides to 365 pediatric patients with influenza-like symptoms and compared the clinical course and complication rate of pneumonia. One hundred and fifty-four patients received cephalosporins (Group 1) and 211 received macrolides (Group 2). There were no significant differences in age, male/female ratio and body weight between the two groups. Macrolides alleviated fever significantly faster than cephalospoins (3.8± 1.4 days vs 4.3± 1.4 days), though maximum body temperature showed no significant difference between the two groups. Thirty-nine patients underwent laboratory examinations and twenty-nine had high influenza A (H3N2) virus haemagglutinate inhibition (HI) titer, six had high influenza B (B1) virus HI titer and four did not show any elevation of influenza virus HI titer. Thirteen patients in Group 1 and two patients in Group 2 suffered from pneumonia and the complication rate was significantly lower in Group 1 than in Group 2 (8.4% vs 0.9%). All of them recovered within two weeks and did not have any other complications.
Conclusion:Macrolides are more effective in reducing the time required to alleviate fever and complication rate of pneumonia than cepharosporines in children with influenza and influenza-like illness. These results indicate that macrolides may have therapeutic value for influenza virus infection.

Correspondence to Keiko Ninomiya, Department of Pediatrics, Nissan Tamagowa Hospital, 4-8-1 Seta, Setagaya-ku, Tokyo 158-0095, Japan
ninomiyakeiko/pediatrtics@nms.ac.jp

ArticleTitle	Effect of Maclorides on Duration and Resolution of Symptoms and Complication of Pneumonia in Children with Influenza
AuthorList	Keiko Ninomiya¹, Tomoko Fukui², Toshiko Imai², Motoyo Matsui² and Kazuhiko Matsuoka¹
Affiliation	¹Department of Pediatrics, Nissan Tamagawa Hospital, ²Department of Pediatrics Nippon Medical School
Language	EN
Volume	69
Issue	1
Year	2002
Page	53-57
Received	September 17, 2001
Accepted	October 17, 2001
Keywords	influenza, pneumonia, macrolides, cepharosporins
Abstract	We randomly administered cephalosporins or macrolides to 365 pediatric patients with influenza-like symptoms and compared the clinical course and complication rate of pneumonia. One hundred and fifty-four patients received cephalosporins (Group 1) and 211 received macrolides (Group 2). There were no significant differences in age, male/female ratio and body weight between the two groups. Macrolides alleviated fever significantly faster than cephalospoins (3.8± 1.4 days vs 4.3± 1.4 days), though maximum body temperature showed no significant difference between the two groups. Thirty-nine patients underwent laboratory examinations and twenty-nine had high influenza A (H3N2) virus haemagglutinate inhibition (HI) titer, six had high influenza B (B1) virus HI titer and four did not show any elevation of influenza virus HI titer. Thirteen patients in Group 1 and two patients in Group 2 suffered from pneumonia and the complication rate was significantly lower in Group 1 than in Group 2 (8.4% vs 0.9%). All of them recovered within two weeks and did not have any other complications. Conclusion:Macrolides are more effective in reducing the time required to alleviate fever and complication rate of pneumonia than cepharosporines in children with influenza and influenza-like illness. These results indicate that macrolides may have therapeutic value for influenza virus infection.
Correspondence to	Keiko Ninomiya, Department of Pediatrics, Nissan Tamagowa Hospital, 4-8-1 Seta, Setagaya-ku, Tokyo 158-0095, Japan ninomiyakeiko/pediatrtics@nms.ac.jp