Journal of Nippon Medical School: Vol.69 No.2 page.160

Journal of Nippon Medical School

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ArticleTitle Endoscopic Scleroligation is a Superior New Technique for Preventing Recurrence of Esophageal Varices

AuthorList Takashi Tajiri, Masahiko Onda, Hiroshi Yoshida, Yasuhiro Mamada, Nobuhiko Taniai, Matsuomi Umehara, Masahito Toba and Kiyohiko Yamashita

Affiliation First Department of Surgery, Nippon Medical School

Language EN

Volume 69

Issue 2

Year 2002

Page 160-164

Received July 9, 2001

Accepted September 25, 2001

Keywords esophageal varices, endoscopic ligation, endoscopic sclerotherapy, combination therapy

Abstract This study compared a new method, endoscopic scleroligation, intravariceal injection sclerotherapy followed by ligation plus extravariceal injection sclerotherapy, with ligation plus extravariceal injection sclerotherapy. Fifty-nine patients with cirrhosis and esophageal varices were treated by endoscopic scleroligation (ESL group, n=28) or ligation plus extravariceal injection sclerotherapy (EVL+extraEIS group, n=31). The demographics and clinical characteristics of the two treatment groups were similar, as was the rate of complete eradication with initial treatment. However, the 1- and 3-year cumulative recurrence rates in the ESL group (3.8% and 22.4%) were very significantly lower than those in the EVL+extraEIS group (48.3% and 81.0%)(p <0.0001). The overall survival rates in the two groups were similar. In conclusion, endoscopic scleroligation is superior to ligation plus extravariceal injection sclerotherapy in preventing variceal recurrence. The efficacy of intravariceal injection sclerotherapy before ligation is believed to arise from the eradication of feeder vessels.

Correspondence to Takashi Tajiri, MD, First Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
tajirit@nms.ac.jp

ArticleTitle	Endoscopic Scleroligation is a Superior New Technique for Preventing Recurrence of Esophageal Varices
AuthorList	Takashi Tajiri, Masahiko Onda, Hiroshi Yoshida, Yasuhiro Mamada, Nobuhiko Taniai, Matsuomi Umehara, Masahito Toba and Kiyohiko Yamashita
Affiliation	First Department of Surgery, Nippon Medical School
Language	EN
Volume	69
Issue	2
Year	2002
Page	160-164
Received	July 9, 2001
Accepted	September 25, 2001
Keywords	esophageal varices, endoscopic ligation, endoscopic sclerotherapy, combination therapy
Abstract	This study compared a new method, endoscopic scleroligation, intravariceal injection sclerotherapy followed by ligation plus extravariceal injection sclerotherapy, with ligation plus extravariceal injection sclerotherapy. Fifty-nine patients with cirrhosis and esophageal varices were treated by endoscopic scleroligation (ESL group, n=28) or ligation plus extravariceal injection sclerotherapy (EVL+extraEIS group, n=31). The demographics and clinical characteristics of the two treatment groups were similar, as was the rate of complete eradication with initial treatment. However, the 1- and 3-year cumulative recurrence rates in the ESL group (3.8% and 22.4%) were very significantly lower than those in the EVL+extraEIS group (48.3% and 81.0%)(p <0.0001). The overall survival rates in the two groups were similar. In conclusion, endoscopic scleroligation is superior to ligation plus extravariceal injection sclerotherapy in preventing variceal recurrence. The efficacy of intravariceal injection sclerotherapy before ligation is believed to arise from the eradication of feeder vessels.
Correspondence to	Takashi Tajiri, MD, First Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan tajirit@nms.ac.jp