Journal of Nippon Medical School: Vol.69 No.5 page.415

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ArticleTitle Clinical Relevance of Grade III Placenta in Assessment of Low Level of Plasma Antithrombin III Activity in Pregnant Women at Term

AuthorList Hirobumi Asakura, Akihito Nakai and Tsutomu Araki

Affiliation Department of Obstetrics and Gynecology, Nippon Medical School

Language EN

Volume 69

Issue 5

Year 2002

Page 415-421

Received March 8, 2002

Accepted April 3, 2002

Keywords grade III placenta, antithrombin III, blood coagulation, pregnancy

Abstract We previously reported the correlation of placenta grade with low antithrombin III (ATIII) in pregnant women at term. In this report, the clinical relevance of grade III placenta in the assessment of low plasma ATIII was compared with other factors that raise the risk of blood hypercoagulability.
Methods: We investigated the correlation of low ATIII with ultrasonographic placental grade as well as with age, parity, body mass index (BMI), blood pressure, platelet counts and hematocrit in 164 healthy pregnant women at term. We calculated the odds ratio for each variable (clnical factor) to predict low ATIII activity of less than 80% using a multiple logistic regression model.
Results: Low ATIII activity was associated with BMI≥28, systolic blood pressure≥136 mmHg, diastolic blood pressure≥84 mmHg and the presence of grade III placenta. The odds ratio of low ATIII activity was 3.2 for women with BMI≥28 (95%Confidential Interval (CI) : 1.1-9.7) ; 2.7 (95% CI: 0.7-10.3) for women with systolic blood pressure≥136 mmHg; 1.9 (95% CI: 0.3-11.9) for those with diastolic blood pressure≥84 mmHg; and 2.4 (95% CI: 0.8-6.9) for those with placental grade III.
Conclusion: We can assess low placenta ATIII activity by using placental grade with similar odds ratios to BMI and blood pressure in pregnant women at term.

Correspondence to Hirobumi Asakura, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
morgen@nms.ac.jp

ArticleTitle	Clinical Relevance of Grade III Placenta in Assessment of Low Level of Plasma Antithrombin III Activity in Pregnant Women at Term
AuthorList	Hirobumi Asakura, Akihito Nakai and Tsutomu Araki
Affiliation	Department of Obstetrics and Gynecology, Nippon Medical School
Language	EN
Volume	69
Issue	5
Year	2002
Page	415-421
Received	March 8, 2002
Accepted	April 3, 2002
Keywords	grade III placenta, antithrombin III, blood coagulation, pregnancy
Abstract	We previously reported the correlation of placenta grade with low antithrombin III (ATIII) in pregnant women at term. In this report, the clinical relevance of grade III placenta in the assessment of low plasma ATIII was compared with other factors that raise the risk of blood hypercoagulability. Methods: We investigated the correlation of low ATIII with ultrasonographic placental grade as well as with age, parity, body mass index (BMI), blood pressure, platelet counts and hematocrit in 164 healthy pregnant women at term. We calculated the odds ratio for each variable (clnical factor) to predict low ATIII activity of less than 80% using a multiple logistic regression model. Results: Low ATIII activity was associated with BMI≥28, systolic blood pressure≥136 mmHg, diastolic blood pressure≥84 mmHg and the presence of grade III placenta. The odds ratio of low ATIII activity was 3.2 for women with BMI≥28 (95%Confidential Interval (CI) : 1.1-9.7) ; 2.7 (95% CI: 0.7-10.3) for women with systolic blood pressure≥136 mmHg; 1.9 (95% CI: 0.3-11.9) for those with diastolic blood pressure≥84 mmHg; and 2.4 (95% CI: 0.8-6.9) for those with placental grade III. Conclusion: We can assess low placenta ATIII activity by using placental grade with similar odds ratios to BMI and blood pressure in pregnant women at term.
Correspondence to	Hirobumi Asakura, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan morgen@nms.ac.jp