Journal of Nippon Medical School: Vol.69 No.6 page.571

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ArticleTitle T1-weighted Magnetic Resonance Imaging Sequence Appropriate for the Evaluation of the Longitudinal Relaxation Effect of Superparamagnetic Iron Oxide: a Phantom Study

AuthorList Katsuya Takahama, Yasuo Amano, Hiromitsu Hayashi and Tatsuo Kumazaki

Affiliation Department of Radiology, Nippon Medical School

Language EN

Volume 69

Issue 6

Year 2002

Page 571-576

Received July 10, 2002

Accepted August 19, 2002

Keywords longitudinal relaxation effect, magnetic resonance imaging, superparamagnetic iron oxide, ferumoxides, phantom study

Abstract
The goal of this study was to determine a T1-weighted magnetic resonance (MR) imaging sequence appropriate for evaluating the longitudinal relaxation effect of superparamagnetic iron oxide (ferumoxides) in a phantom study. An agarose phantom that included various concentrations of ferumoxides (0∼0.5 mmol/l in 0.05 mmol/l increments) was examined for six types of T1-weighted imaging sequences using a 1.5-T MR unit. Three-dimensional (3D) fast spoiled gradient-echo (SPGR) imaging with a short echo time showed a strong linear correlation between the concentration of ferumoxides and the enhancement ratio. Two-dimensional (2D) fast SPGR imaging showed a high signal-to-noise ratio of the phantom even at low ferumoxides concentrations. These results suggest that 3D fast SPGR imaging is an appropriate technique for the evaluation of the longitudinal relaxation effect of ferumoxides, and that 2D fast SPGR imaging can be useful for evaluating the longitudinal relaxation effect at lower ferumoxides concentrations.

Correspondence to Kastuya Takahama, MD, Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
takahama@nms.ac.jp

ArticleTitle	T1-weighted Magnetic Resonance Imaging Sequence Appropriate for the Evaluation of the Longitudinal Relaxation Effect of Superparamagnetic Iron Oxide: a Phantom Study
AuthorList	Katsuya Takahama, Yasuo Amano, Hiromitsu Hayashi and Tatsuo Kumazaki
Affiliation	Department of Radiology, Nippon Medical School
Language	EN
Volume	69
Issue	6
Year	2002
Page	571-576
Received	July 10, 2002
Accepted	August 19, 2002
Keywords	longitudinal relaxation effect, magnetic resonance imaging, superparamagnetic iron oxide, ferumoxides, phantom study
Abstract	The goal of this study was to determine a T1-weighted magnetic resonance (MR) imaging sequence appropriate for evaluating the longitudinal relaxation effect of superparamagnetic iron oxide (ferumoxides) in a phantom study. An agarose phantom that included various concentrations of ferumoxides (0∼0.5 mmol/l in 0.05 mmol/l increments) was examined for six types of T1-weighted imaging sequences using a 1.5-T MR unit. Three-dimensional (3D) fast spoiled gradient-echo (SPGR) imaging with a short echo time showed a strong linear correlation between the concentration of ferumoxides and the enhancement ratio. Two-dimensional (2D) fast SPGR imaging showed a high signal-to-noise ratio of the phantom even at low ferumoxides concentrations. These results suggest that 3D fast SPGR imaging is an appropriate technique for the evaluation of the longitudinal relaxation effect of ferumoxides, and that 2D fast SPGR imaging can be useful for evaluating the longitudinal relaxation effect at lower ferumoxides concentrations.
Correspondence to	Kastuya Takahama, MD, Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan takahama@nms.ac.jp