Journal of Nippon Medical School: Vol.70 No.1 page.012

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ArticleTitle Effect of the Surface Potential of the Hemodialysis Membrane and the Electrical Charge of the Gadolinium Contrast Medium on Dialyzability

AuthorList Susumu Okada¹, Kohei Inoue¹, Tetsuji Kijima¹, Kiwayo Katagiri², Tatsuo Kumazaki²

Affiliation ¹Department of Radiology, Chiba-Hokuso Hospital, Nippon Medical School ²Department of Radiology, Nippon Medical School

Language EN

Volume 70

Issue 1

Year 2003

Page 12-15

Received July 4, 2002

Accepted August 12, 2002

Keywords hemodialysis, gadolinium contrast medium, membrane potential

Abstract
Purpose: To search for methods of improving the excretion of injected gadolinium contrast medium (GdCM) in hemodialysis (HD) patients, we investigated the effect of the surface potential of HD membranes and the electrical charge of GdCM on the dialyzability of GdCM.
Materials and Methods: Ionic (Gd-DTPA) or non-ionic (Gd-DO3A) GdCM solutions were dialyzed using a clinical HD unit. Two types of HD membranes, AN69 with a surface potential and PMMA without, were used. GdCM clearance was then calculated.
Results: Gd-DTPA clearance was significantly higher for PMMA membranes than for AN69 membranes. Gd-DO3A clearance was slightly higher for AN69 membranes than for PMMA membranes. The difference in Gd-DTPA and Gd-DO3A clearance values was not significant when PMMA membranes were used.
Conclusion: These data indicate that non-ionic GdCM is preferable to ionic GdCM in patients receiving dialysis through an electrically positive membrane. Either ionic or non-ionic GdCM can be used when a normal dialysis membrane is being used.

Correspondence to Susumu Okada, Department of Radiology, Chiba-Hokuso Hospital, Nippon Medical School, 1715 Kamagari, Inba-mura, Inba-gun, Chiba 270-1613, Japan
okada@nms.ac.jp

ArticleTitle	Effect of the Surface Potential of the Hemodialysis Membrane and the Electrical Charge of the Gadolinium Contrast Medium on Dialyzability
AuthorList	Susumu Okada¹, Kohei Inoue¹, Tetsuji Kijima¹, Kiwayo Katagiri², Tatsuo Kumazaki²
Affiliation	¹Department of Radiology, Chiba-Hokuso Hospital, Nippon Medical School ²Department of Radiology, Nippon Medical School
Language	EN
Volume	70
Issue	1
Year	2003
Page	12-15
Received	July 4, 2002
Accepted	August 12, 2002
Keywords	hemodialysis, gadolinium contrast medium, membrane potential
Abstract	Purpose: To search for methods of improving the excretion of injected gadolinium contrast medium (GdCM) in hemodialysis (HD) patients, we investigated the effect of the surface potential of HD membranes and the electrical charge of GdCM on the dialyzability of GdCM. Materials and Methods: Ionic (Gd-DTPA) or non-ionic (Gd-DO3A) GdCM solutions were dialyzed using a clinical HD unit. Two types of HD membranes, AN69 with a surface potential and PMMA without, were used. GdCM clearance was then calculated. Results: Gd-DTPA clearance was significantly higher for PMMA membranes than for AN69 membranes. Gd-DO3A clearance was slightly higher for AN69 membranes than for PMMA membranes. The difference in Gd-DTPA and Gd-DO3A clearance values was not significant when PMMA membranes were used. Conclusion: These data indicate that non-ionic GdCM is preferable to ionic GdCM in patients receiving dialysis through an electrically positive membrane. Either ionic or non-ionic GdCM can be used when a normal dialysis membrane is being used.
Correspondence to	Susumu Okada, Department of Radiology, Chiba-Hokuso Hospital, Nippon Medical School, 1715 Kamagari, Inba-mura, Inba-gun, Chiba 270-1613, Japan okada@nms.ac.jp