Journal of Nippon Medical School: Vol.70 No.2 page.129

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ArticleTitle Evaluation of the Neurotoxicity of Paclitaxel and Carboplatin by Current Perception Threshold in Ovarian Cancer Patients

AuthorList Daisuke Doi, Yujiro Ota, Hideki Konishi, Koichi Yoneyama and Tsutomu Araki

Affiliation Department of Obstetrics and Gynecology, Nippon Medical School

Language EN

Volume 70

Issue 2

Year 2003

Page 129-134

Received August 26, 2002

Accepted October 21, 2002

Keywords ovarian carcinoma, paclitaxel, carboplatin, neurotoxicity, CPT

Abstract Objectives: Combination chemotherapy consisting of paclitaxel and carboplatin has recently started to be given as the regimen of first choice for epithelial ovarian cancer. One of its side effects, however, is neurotoxicity, and this neurotoxicity has been reported to be the dose-limiting factor. Since it is necessary to measure the severity of the neurotoxicity objectively and quantitatively, we evaluated it on the basis of current perception threshold (CPT) values, which is easy and non-invasive.
Method: Sixteen patients with epithelial ovarian cancer were given paclitaxel (175 mg/m², 3 hours) and carboplatin (area under the curve of 5) every three weeks, and the CPT values were measured at two sites on the day before and several times after administration.
Results: All patients exhibited mild neurotoxicity, but it was never so severe that chemotherapy could not be continued. The CPT values peaked on day 4 during one course of chemotherapy, but decreased thereafter and returned almost to the baseline by three weeks, in the same way as the patients' complaints. The CPT values decreased with the number of courses, and patients' complaints gradually increased. The CPT values increased more in the cases previously treated with cisplatin than in the other cases. These changes were seen at 2,000 Hz, which generally corresponds to large, myelinated nerves.
Conclusion: There were correlations between the changes in the patients' CPT values and their degree of neurotoxicity. We expect to be able to predict severe neurotoxicity and evaluate the effect of drug therapy for neurotoxicity by measuring CPT values.

Correspondence to Daisuke Doi, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
doidai@aol.com

ArticleTitle	Evaluation of the Neurotoxicity of Paclitaxel and Carboplatin by Current Perception Threshold in Ovarian Cancer Patients
AuthorList	Daisuke Doi, Yujiro Ota, Hideki Konishi, Koichi Yoneyama and Tsutomu Araki
Affiliation	Department of Obstetrics and Gynecology, Nippon Medical School
Language	EN
Volume	70
Issue	2
Year	2003
Page	129-134
Received	August 26, 2002
Accepted	October 21, 2002
Keywords	ovarian carcinoma, paclitaxel, carboplatin, neurotoxicity, CPT
Abstract	Objectives: Combination chemotherapy consisting of paclitaxel and carboplatin has recently started to be given as the regimen of first choice for epithelial ovarian cancer. One of its side effects, however, is neurotoxicity, and this neurotoxicity has been reported to be the dose-limiting factor. Since it is necessary to measure the severity of the neurotoxicity objectively and quantitatively, we evaluated it on the basis of current perception threshold (CPT) values, which is easy and non-invasive. Method: Sixteen patients with epithelial ovarian cancer were given paclitaxel (175 mg/m², 3 hours) and carboplatin (area under the curve of 5) every three weeks, and the CPT values were measured at two sites on the day before and several times after administration. Results: All patients exhibited mild neurotoxicity, but it was never so severe that chemotherapy could not be continued. The CPT values peaked on day 4 during one course of chemotherapy, but decreased thereafter and returned almost to the baseline by three weeks, in the same way as the patients' complaints. The CPT values decreased with the number of courses, and patients' complaints gradually increased. The CPT values increased more in the cases previously treated with cisplatin than in the other cases. These changes were seen at 2,000 Hz, which generally corresponds to large, myelinated nerves. Conclusion: There were correlations between the changes in the patients' CPT values and their degree of neurotoxicity. We expect to be able to predict severe neurotoxicity and evaluate the effect of drug therapy for neurotoxicity by measuring CPT values.
Correspondence to	Daisuke Doi, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan doidai@aol.com