Journal of Nippon Medical School: Vol.70 No.2 page.175

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ArticleTitle The Longitudinal Course of Two Cases with Cretinism Diagnosed After Adolescence

AuthorList Tsunenori Hirayama^{1, 2}, Kohji Niho¹, Osamu Fujino² and Mutsumi Murakami²

Affiliation ¹Department of Pediatrics, National Fukushima Hospital, Fukushima
²Department of Pediatrics, Nippon Medical School

Language EN

Volume 70

Issue 2

Year 2003

Page 175-178

Received October 15, 2002

Accepted November 15, 2002

Keywords Cretinism, complications, ovarian cyst, NIDDM, ectopic thyroid gland

Abstract In Japan, mass screening tests on newborns for Cretinism have been performed since 1984, Cretinism is a very rare condition. We report the clinical course and complications of longitudinal thyroid hormone replacement therapy (liothyronine sodium: T3) of two women with Cretinism and ectopic thyroid gland for the past 33 years until 2001.
They were born in April 1951 (Case 1) and in January 1952 (Case 2). On admission in June 1968, they were 17 and 16 years old. They had short stature, mental retardation, macroglossia, saddle nose, retardation of bone maturation, edematous face, coexistence of permanent teeth and deciduous teeth, abdominal distention, hypotonia, anemia, hypophosphatemia and hypercholesterolemia.
After admission, Case 2 had an appendectomy for appendicitis. She was found to have a right ovarian cyst, but was not operated upon. Later, the right ovarian cyst disappeared during thyroid hormone replacement therapy. The complication in this case was NIDDM. Over secretion of thyroid hormone in for example, hyperthyroidism sometimes induces NIDDM.
On their admission, a levothyroxine sodium (T4: Thyradin S) was unavailable in Japan, so we had no choice but to treat them with liothyronine sodium for thyroid hormone replacement therapy. We suspect that liothyronine sodium replacement therapy probably induced NIDDM. They experienced improved bone maturation, anemia, hypophsphatemia and hypercholesterolemia, but their intellectual and mental disabilities were not improved.

Correspondence to Tsunenori Hirayama, MD, Department of Pediatrics, National Fukushima Hospital, 13 Ashidatsuka, Sukagawa-shi, Fukushima 962-8507, Japan
tunezou@nms.ac.jp

ArticleTitle	The Longitudinal Course of Two Cases with Cretinism Diagnosed After Adolescence
AuthorList	Tsunenori Hirayama^{1, 2}, Kohji Niho¹, Osamu Fujino² and Mutsumi Murakami²
Affiliation	¹Department of Pediatrics, National Fukushima Hospital, Fukushima ²Department of Pediatrics, Nippon Medical School
Language	EN
Volume	70
Issue	2
Year	2003
Page	175-178
Received	October 15, 2002
Accepted	November 15, 2002
Keywords	Cretinism, complications, ovarian cyst, NIDDM, ectopic thyroid gland
Abstract	In Japan, mass screening tests on newborns for Cretinism have been performed since 1984, Cretinism is a very rare condition. We report the clinical course and complications of longitudinal thyroid hormone replacement therapy (liothyronine sodium: T3) of two women with Cretinism and ectopic thyroid gland for the past 33 years until 2001. They were born in April 1951 (Case 1) and in January 1952 (Case 2). On admission in June 1968, they were 17 and 16 years old. They had short stature, mental retardation, macroglossia, saddle nose, retardation of bone maturation, edematous face, coexistence of permanent teeth and deciduous teeth, abdominal distention, hypotonia, anemia, hypophosphatemia and hypercholesterolemia. After admission, Case 2 had an appendectomy for appendicitis. She was found to have a right ovarian cyst, but was not operated upon. Later, the right ovarian cyst disappeared during thyroid hormone replacement therapy. The complication in this case was NIDDM. Over secretion of thyroid hormone in for example, hyperthyroidism sometimes induces NIDDM. On their admission, a levothyroxine sodium (T4: Thyradin S) was unavailable in Japan, so we had no choice but to treat them with liothyronine sodium for thyroid hormone replacement therapy. We suspect that liothyronine sodium replacement therapy probably induced NIDDM. They experienced improved bone maturation, anemia, hypophsphatemia and hypercholesterolemia, but their intellectual and mental disabilities were not improved.
Correspondence to	Tsunenori Hirayama, MD, Department of Pediatrics, National Fukushima Hospital, 13 Ashidatsuka, Sukagawa-shi, Fukushima 962-8507, Japan tunezou@nms.ac.jp