Journal of Nippon Medical School: Vol.70 No.3 page.219

Journal of Nippon Medical School

Select Language
in Japanese < > in English

Full Text of this Article

in English PDF (748K)

ArticleTitle Pre-treatment Mitotic Index Versus Computer-quantitated Ki-67 Nuclear Antigen Labeling Index as Predictors of Response to Neoadjuvant Chemotherapy in Uterine Cervical Carcinoma

AuthorList Seiryu Kamoi¹, Yoshiharu Ohaki², Yasuo Amano⁴, Osamu Mori², Norihiro Matsushita¹, Daiske Doi¹, Susumu Okada⁴, Yuuichi Sugisaki³, Takashi Kawamura¹ and Tsutomu Araki¹

Affiliation ¹Department of Obstetrics and Gynecology, Nippon Medical School
²Division of Surgical Pathology, Chiba-Hokusoh Hospital, Nippon Medical School
³Division of Surgical Pathology, Nippon Medical School Hospital
⁴Department of Radiology, Nippon Medical School

Language EN

Volume 70

Issue 3

Year 2003

Page 219-226

Received October 18, 2002

Accepted November 27, 2002

Keywords uterine cervical carcinoma, mitotic index, Ki-67 nuclear antigen labeling index, predictors of chemotherapy response, platinum regimen

Abstract In order to evaluate the usefulness of the mitotic index (MI) and the Ki-67 nuclear antigen labeling index (Ki67LI) in pre-treatment biopsy specimens as predictors of response to chemotherapy for uterine cervical carcinomas, twelve patients with squamous cell carcinoma who received neoadjuvant chemotherapy before radical surgery were investigated. The MI and computer-quantitated Ki67LI were determined using H&E and immunostained slides of biopsy specimens collected before chemotherapy. Tumor size was measured three-dimensionally by MR imaging, and assessed before and after chemotherapy. We compared the values of MI and Ki67LI with changes in tumor size and the following results were obtained.
1) The percentage reduction in tumor size ranged from 0 to 98%. The MI ranged from 0.5 to 15, and Ki67LI ranged from 0.01 to 50.1%. 2) A significant positive correlation was observed between response to chemotherapy assessed on MR image and MI [Spearman's correlation coefficient (r) =0.66, n=12, p=0.027], and between response to chemotherapy and Ki67LI (r=0.72, n=12, p=0.017). 3) A significant correlation was observed between MI and computer-assessed Ki67 LI [Pearson's correlation coefficient (r) =0.80, n=12, p=0.002]. Therefore, pre-chemotherapy MI and Ki67LI were both good predictors of response to platinum-based chemotherapy. Because MI is technically more convenient and economically less expensive than computer-quantitated Ki67LI, MI remains a simple and reliable predictor from the clinical point of view.

Correspondence to Seiryu Kamoi, MD, Department of Obstetrics and Gynecology, Chiba-Hokusoh Hospital, Nippon Medical School, 1715 Kamagari, Inba-mura, Inba-gun, Chiba 270-1694, Japan
skamoi@nms.ac.jp

ArticleTitle	Pre-treatment Mitotic Index Versus Computer-quantitated Ki-67 Nuclear Antigen Labeling Index as Predictors of Response to Neoadjuvant Chemotherapy in Uterine Cervical Carcinoma
AuthorList	Seiryu Kamoi¹, Yoshiharu Ohaki², Yasuo Amano⁴, Osamu Mori², Norihiro Matsushita¹, Daiske Doi¹, Susumu Okada⁴, Yuuichi Sugisaki³, Takashi Kawamura¹ and Tsutomu Araki¹
Affiliation	¹Department of Obstetrics and Gynecology, Nippon Medical School ²Division of Surgical Pathology, Chiba-Hokusoh Hospital, Nippon Medical School ³Division of Surgical Pathology, Nippon Medical School Hospital ⁴Department of Radiology, Nippon Medical School
Language	EN
Volume	70
Issue	3
Year	2003
Page	219-226
Received	October 18, 2002
Accepted	November 27, 2002
Keywords	uterine cervical carcinoma, mitotic index, Ki-67 nuclear antigen labeling index, predictors of chemotherapy response, platinum regimen
Abstract	In order to evaluate the usefulness of the mitotic index (MI) and the Ki-67 nuclear antigen labeling index (Ki67LI) in pre-treatment biopsy specimens as predictors of response to chemotherapy for uterine cervical carcinomas, twelve patients with squamous cell carcinoma who received neoadjuvant chemotherapy before radical surgery were investigated. The MI and computer-quantitated Ki67LI were determined using H&E and immunostained slides of biopsy specimens collected before chemotherapy. Tumor size was measured three-dimensionally by MR imaging, and assessed before and after chemotherapy. We compared the values of MI and Ki67LI with changes in tumor size and the following results were obtained. 1) The percentage reduction in tumor size ranged from 0 to 98%. The MI ranged from 0.5 to 15, and Ki67LI ranged from 0.01 to 50.1%. 2) A significant positive correlation was observed between response to chemotherapy assessed on MR image and MI [Spearman's correlation coefficient (r) =0.66, n=12, p=0.027], and between response to chemotherapy and Ki67LI (r=0.72, n=12, p=0.017). 3) A significant correlation was observed between MI and computer-assessed Ki67 LI [Pearson's correlation coefficient (r) =0.80, n=12, p=0.002]. Therefore, pre-chemotherapy MI and Ki67LI were both good predictors of response to platinum-based chemotherapy. Because MI is technically more convenient and economically less expensive than computer-quantitated Ki67LI, MI remains a simple and reliable predictor from the clinical point of view.
Correspondence to	Seiryu Kamoi, MD, Department of Obstetrics and Gynecology, Chiba-Hokusoh Hospital, Nippon Medical School, 1715 Kamagari, Inba-mura, Inba-gun, Chiba 270-1694, Japan skamoi@nms.ac.jp