Journal of Nippon Medical School: Vol.70 No.3 page.270

Journal of Nippon Medical School

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ArticleTitle Serum Leptin Concentration in Young Adult Women with Ovulatory Dysfunction

AuthorList Hisayuki Kaseki¹, Satomi Maruyama², Kaisuke Ishihara¹ and Tsutomu Araki¹

Affiliation ¹Department of Obstetrics and Gynecology, Nippon Medical School
²Graduate School of Nutrition, Showa Women's University

Language EN

Volume 70

Issue 3

Year 2003

Page 270-273

Received August 29, 2002

Accepted December 25, 2002

Keywords leptin, BMI, percent body fat, ovulation, ovulatory dysfunction

Abstract To investigate the functional role of leptin in human ovulation, we measured serum leptin, LH, FSH and estradiol in 16 young adult women suffering from ovulatory dysfunction with BMI ranging from17.5 to 24.5 (group A). The control subjects included 12 women with regular ovulation and matched age and BMI (group B). We found that serum leptin concentration in group A subjects was significantly lower than that in group B subjects (4.1±0.5 vs. 6.1±0.4 ng/ml, p<0.01). The percent body fat, estradiol, LH and FSH concentrations in groups A and B were not significantly different. These results indicate that anovulatory young adult women have lower leptin concentration than women with regular ovulation, thus suggesting a key role for leptin in regular ovulation or ovulatory dysfunction.

Correspondence to Hisayuki Kaseki MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School Second Hospital, 1-396 Kosugi-cho, Nakahara-Ku, Kawasaki, Kanagawa 211-8533, Japan
h-kaseki@bea.hi-ho.ac.jp

ArticleTitle	Serum Leptin Concentration in Young Adult Women with Ovulatory Dysfunction
AuthorList	Hisayuki Kaseki¹, Satomi Maruyama², Kaisuke Ishihara¹ and Tsutomu Araki¹
Affiliation	¹Department of Obstetrics and Gynecology, Nippon Medical School ²Graduate School of Nutrition, Showa Women's University
Language	EN
Volume	70
Issue	3
Year	2003
Page	270-273
Received	August 29, 2002
Accepted	December 25, 2002
Keywords	leptin, BMI, percent body fat, ovulation, ovulatory dysfunction
Abstract	To investigate the functional role of leptin in human ovulation, we measured serum leptin, LH, FSH and estradiol in 16 young adult women suffering from ovulatory dysfunction with BMI ranging from17.5 to 24.5 (group A). The control subjects included 12 women with regular ovulation and matched age and BMI (group B). We found that serum leptin concentration in group A subjects was significantly lower than that in group B subjects (4.1±0.5 vs. 6.1±0.4 ng/ml, p<0.01). The percent body fat, estradiol, LH and FSH concentrations in groups A and B were not significantly different. These results indicate that anovulatory young adult women have lower leptin concentration than women with regular ovulation, thus suggesting a key role for leptin in regular ovulation or ovulatory dysfunction.
Correspondence to	Hisayuki Kaseki MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School Second Hospital, 1-396 Kosugi-cho, Nakahara-Ku, Kawasaki, Kanagawa 211-8533, Japan h-kaseki@bea.hi-ho.ac.jp