Journal of Nippon Medical School: Vol.70 No.6 page.475

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ArticleTitle Effects of Intravenous Infusion Rate of Oxytocin on Thoracic Epidural Pressure in Parturients Undregoing Elective Cesarean Section

AuthorList Takehiko Kikutani, Masayuki Oshima, Kikuzo Sugimoto and Yoichi Shimada

Affiliation Department of Anesthesiology, Nippon Medical School Second Hospital

Language EN

Volume 70

Issue 6

Year 2003

Page 475-479

Received June 11, 2003

Accepted June 30, 2003

Keywords epidural pressure, obstetrical anesthesia, cesarean section, oxytocin

Abstract The effects of intravenous oxytocin on thoracic epidural pressure during cesarean section were studied in 90 parturients (American Society of Anesthesiologists physical atatus class I or II) after obtaining informed consent. The subjects were randomized to either a control (control group; n=30), bolus (bolus group; n=30) or drip treatment group (drip group; n=30). The subjects were anesthetized with 11∼12 mg of intrathecal isobaric bupivacaine (0.5%). An epidural catheter placed at Th 11/12 was connected to a pressure transducer to continuously monitor thoracic epidural pressure. Ten units of oxytocin were administered over 30 seconds in the bolus group and over 5 minutes in the drip group after fetus delivery. We analyzed epidural pressure, mean blood pressure, and heart rate, until 5 minutes after fetus delivery. Epidural pressures in both bolus and drip groups increased after fetus delivery compared with control group (P<0.0001). Epidural pressure immediately after placental delivery in the bolus group was higher than in the control group (p<0.0001) and epidural pressure at 5 minutes after fetus delivery in the drip group was higher than in the control group (p=0.0452). There were no significant differences in changes in blood pressure and heart rate among the three groups. We concluded that the increase in epidural pressure with intravenous administration of oxytocin 10 units over 5 minutes was lower than with intravenous administration of oxytocin 10 units over 30 seconds after fetus delivery.

Correspondence to Takehiko Kikutani, MD, Department of Anesthesiology, Nippon Medical School Second Hospital, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki City, Kanagawa 211-8533, Japan
take.145@viola.ocn.ac.jp

ArticleTitle	Effects of Intravenous Infusion Rate of Oxytocin on Thoracic Epidural Pressure in Parturients Undregoing Elective Cesarean Section
AuthorList	Takehiko Kikutani, Masayuki Oshima, Kikuzo Sugimoto and Yoichi Shimada
Affiliation	Department of Anesthesiology, Nippon Medical School Second Hospital
Language	EN
Volume	70
Issue	6
Year	2003
Page	475-479
Received	June 11, 2003
Accepted	June 30, 2003
Keywords	epidural pressure, obstetrical anesthesia, cesarean section, oxytocin
Abstract	The effects of intravenous oxytocin on thoracic epidural pressure during cesarean section were studied in 90 parturients (American Society of Anesthesiologists physical atatus class I or II) after obtaining informed consent. The subjects were randomized to either a control (control group; n=30), bolus (bolus group; n=30) or drip treatment group (drip group; n=30). The subjects were anesthetized with 11∼12 mg of intrathecal isobaric bupivacaine (0.5%). An epidural catheter placed at Th 11/12 was connected to a pressure transducer to continuously monitor thoracic epidural pressure. Ten units of oxytocin were administered over 30 seconds in the bolus group and over 5 minutes in the drip group after fetus delivery. We analyzed epidural pressure, mean blood pressure, and heart rate, until 5 minutes after fetus delivery. Epidural pressures in both bolus and drip groups increased after fetus delivery compared with control group (P<0.0001). Epidural pressure immediately after placental delivery in the bolus group was higher than in the control group (p<0.0001) and epidural pressure at 5 minutes after fetus delivery in the drip group was higher than in the control group (p=0.0452). There were no significant differences in changes in blood pressure and heart rate among the three groups. We concluded that the increase in epidural pressure with intravenous administration of oxytocin 10 units over 5 minutes was lower than with intravenous administration of oxytocin 10 units over 30 seconds after fetus delivery.
Correspondence to	Takehiko Kikutani, MD, Department of Anesthesiology, Nippon Medical School Second Hospital, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki City, Kanagawa 211-8533, Japan take.145@viola.ocn.ac.jp