Journal of Nippon Medical School: Vol.70 No.6 page.480

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ArticleTitle Changes in Plasma Endothelin-1 After Elective Cesarean Section in Women with Preeclampsia and the Relationship to Thrombocytopenia

AuthorList Hirobumi Asakura, Akihito Nakai and Toshiyuki Takeshita

Affiliation Department of Obstetrics and Gynecology, Nippon Medical School Second Hospital

Language EN

Volume 70

Issue 6

Year 2003

Page 480-489

Received May 12, 2003

Accepted July 3, 2003

Keywords endothelin-1, preeclampsia, cesarean section, platelet

Abstract Objective: The aim of this study was to clarify the time course of plasma endothelin-1 levels and platelet counts after elective cesarean section in women with preeclampsia, and to investigate the relationship between them postoperatively.
Methods: We studied 20 patients with preeclampsia and 25 healthy pregnant women without preeclampsia who underwent cesarean section and 20 women without preeclampsia who had vaginal deliveries. The plasma endothelin-1 and platelet counts were measured serially after cesarean section.
Results: 1) In patients with preeclampsia, plasma endothelin-1 levels peaked on postoperative day 0 (p<0.05), and remained high, then fell to the preoperative level from day 5. The concentration was lower in healthy pregnant women undergoing cesarean section than in patients with preeclampsia before surgery, but showed a gradual significant increase from postoperative day 0 to postoperative day 3 (p<0.05) before falling. The women who underwent vaginal delivery showed a peak level of endtothelin-1 on the day of delivery but this fell rapidly between day 3. 2) Women with preeclampsia showed a negative correlation between plasma endothelin-1 levels and platelet counts after cesarean section (r=0.46, p<0.01), while women without preeclampsia undergoing cesarean and vaginal deliveries did not. Conclusion: Endothelin-1 production is stimulated after cesarean section, which is paralleled with postpartal thrombocytopenia only in patients with preeclampsia.

Correspondence to Hirobumi Asakura, Department of Obstetrics and Gynecology, Nippon Medical School Second Hospital, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki City, Kanagawa 211-8533, Japan
morgen@nms.ac.jp

ArticleTitle	Changes in Plasma Endothelin-1 After Elective Cesarean Section in Women with Preeclampsia and the Relationship to Thrombocytopenia
AuthorList	Hirobumi Asakura, Akihito Nakai and Toshiyuki Takeshita
Affiliation	Department of Obstetrics and Gynecology, Nippon Medical School Second Hospital
Language	EN
Volume	70
Issue	6
Year	2003
Page	480-489
Received	May 12, 2003
Accepted	July 3, 2003
Keywords	endothelin-1, preeclampsia, cesarean section, platelet
Abstract	Objective: The aim of this study was to clarify the time course of plasma endothelin-1 levels and platelet counts after elective cesarean section in women with preeclampsia, and to investigate the relationship between them postoperatively. Methods: We studied 20 patients with preeclampsia and 25 healthy pregnant women without preeclampsia who underwent cesarean section and 20 women without preeclampsia who had vaginal deliveries. The plasma endothelin-1 and platelet counts were measured serially after cesarean section. Results: 1) In patients with preeclampsia, plasma endothelin-1 levels peaked on postoperative day 0 (p<0.05), and remained high, then fell to the preoperative level from day 5. The concentration was lower in healthy pregnant women undergoing cesarean section than in patients with preeclampsia before surgery, but showed a gradual significant increase from postoperative day 0 to postoperative day 3 (p<0.05) before falling. The women who underwent vaginal delivery showed a peak level of endtothelin-1 on the day of delivery but this fell rapidly between day 3. 2) Women with preeclampsia showed a negative correlation between plasma endothelin-1 levels and platelet counts after cesarean section (r=0.46, p<0.01), while women without preeclampsia undergoing cesarean and vaginal deliveries did not. Conclusion: Endothelin-1 production is stimulated after cesarean section, which is paralleled with postpartal thrombocytopenia only in patients with preeclampsia.
Correspondence to	Hirobumi Asakura, Department of Obstetrics and Gynecology, Nippon Medical School Second Hospital, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki City, Kanagawa 211-8533, Japan morgen@nms.ac.jp