Journal of Nippon Medical School: Vol.70 No.6 page.509

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ArticleTitle 心筋梗塞巣内の凝固壊死心筋の残存について

AuthorList 大森寛子¹, 田村浩一^{2, 3}, 小野真平¹, 揖斐孝之¹, 橋本聡¹, 杉崎祐一^{2, 3}

Affiliation ¹日本医科大学医学部学生
²日本医科大学付属病院病理部
³日本医科大学病理学第1教室

Language JA

Volume 70

Issue 6

Year 2003

Page 509-514

Received May 26, 2003

Accepted September 18, 2003

Keywords myocardial infarction, remnant necrotic tissue, immunohistochemistry, myoglobin, pathology

Abstract Remnants of cardiomyocytes showing coagulation necrosis in the scars caused by myocardial infarction were histopathologically studied. Among 305 autopsy cases of acute and/or healed myocardial infarction, 8 cases (7 men, 1 woman, ages 62∼87 years, mean age 72.1) had masses of cardiomyocytes with coagulation necrosis at the center of the infarction scars more than 3 weeks (21 to 79 days) after the attack of myocardial infarction. All these cases had transmural infarction and more than 80% of the wall thickness of the left ventricle was involved in the infarction. No polymorphonuclear leukocytic infiltration or granulation tissue was found in the necrotic area, but macrophages were observed in the peripheral area adjacent to the scar tissue. Immunohistochemical staining for myoglobin showed no reaction in remnant necrotic cells or pericellular interstitium, which was similar to findings in the necrotic area more than 4 days after the infarction. These findings are important in the pathological diagnosis to distinguish remnant necrosis from acute necrosis, because 4 out of 8 present cases (50%) were misdiagnosed as acute myocardial infarction that superimposed on the previous old infarction.

Correspondence to Koichi Tamura, MD, DMSc, Division of Surgical Pathology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
tamura@nms.ac.jp

ArticleTitle	心筋梗塞巣内の凝固壊死心筋の残存について
AuthorList	大森寛子¹, 田村浩一^{2, 3}, 小野真平¹, 揖斐孝之¹, 橋本聡¹, 杉崎祐一^{2, 3}
Affiliation	¹日本医科大学医学部学生 ²日本医科大学付属病院病理部 ³日本医科大学病理学第1教室
Language	JA
Volume	70
Issue	6
Year	2003
Page	509-514
Received	May 26, 2003
Accepted	September 18, 2003
Keywords	myocardial infarction, remnant necrotic tissue, immunohistochemistry, myoglobin, pathology
Abstract	Remnants of cardiomyocytes showing coagulation necrosis in the scars caused by myocardial infarction were histopathologically studied. Among 305 autopsy cases of acute and/or healed myocardial infarction, 8 cases (7 men, 1 woman, ages 62∼87 years, mean age 72.1) had masses of cardiomyocytes with coagulation necrosis at the center of the infarction scars more than 3 weeks (21 to 79 days) after the attack of myocardial infarction. All these cases had transmural infarction and more than 80% of the wall thickness of the left ventricle was involved in the infarction. No polymorphonuclear leukocytic infiltration or granulation tissue was found in the necrotic area, but macrophages were observed in the peripheral area adjacent to the scar tissue. Immunohistochemical staining for myoglobin showed no reaction in remnant necrotic cells or pericellular interstitium, which was similar to findings in the necrotic area more than 4 days after the infarction. These findings are important in the pathological diagnosis to distinguish remnant necrosis from acute necrosis, because 4 out of 8 present cases (50%) were misdiagnosed as acute myocardial infarction that superimposed on the previous old infarction.
Correspondence to	Koichi Tamura, MD, DMSc, Division of Surgical Pathology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan tamura@nms.ac.jp