Journal of Nippon Medical School: Vol.71 No.2 page.084

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ArticleTitle Indexes of Insulin Resistance using the Oral Glucose Tolerance Test (O-GTT) in Japanese Children and Adolescents

AuthorList Yukashi Ohki, Hiromi Orimo, Megumi Kishi and Takuya Ohkawa

Affiliation Department of Pediatrics, Nippon Medical School

Language EN

Volume 71

Issue 2

Year 2004

Page 84-87

Received September 1, 2003

Accepted September 26, 2003

Keywords insulin resistance, hyperinsulinemia, oral glucose tolerance test (O-GTT), homeostasis model assessment ratio (HOMA-R)

Abstract
An oral glucose tolerance test (O-GTT) was conducted in 96 non-obese healthy children (7∼11 years old) and adolescents (12∼16 years old) to obtain the index of insulin resistance from the insulin (IRI) and C-peptide (CPR) values of fasting, 2-hour postload conditions and the Σ values, and the homeostasis model assessment ratio (HOMA-R) by assuming the value of the mean+2SD to be the upper limit of the normal value for each clinical variable.

The results show that the adolescents, whose insulin resistance is thought to increase, showed higher IRI and CPR values of the 2-hour postload condition and Σ values compared to those of the children, but there were no differences between the 2 age groups in the values of the fasting condition, as well as in the HOMA-R values which were calculated from the fasting values.

These findings indicate that there is a limitation in using fasting values to judge insulin resistance. Instead, using the 2-hour postload values and/or the Σ values is more appropriate.

Correspondence to Correspondence to Yukashi Ohki, Department of Pediatrics, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
yukashi@nms.ac.jp

ArticleTitle	Indexes of Insulin Resistance using the Oral Glucose Tolerance Test (O-GTT) in Japanese Children and Adolescents
AuthorList	Yukashi Ohki, Hiromi Orimo, Megumi Kishi and Takuya Ohkawa
Affiliation	Department of Pediatrics, Nippon Medical School
Language	EN
Volume	71
Issue	2
Year	2004
Page	84-87
Received	September 1, 2003
Accepted	September 26, 2003
Keywords	insulin resistance, hyperinsulinemia, oral glucose tolerance test (O-GTT), homeostasis model assessment ratio (HOMA-R)
Abstract	An oral glucose tolerance test (O-GTT) was conducted in 96 non-obese healthy children (7∼11 years old) and adolescents (12∼16 years old) to obtain the index of insulin resistance from the insulin (IRI) and C-peptide (CPR) values of fasting, 2-hour postload conditions and the Σ values, and the homeostasis model assessment ratio (HOMA-R) by assuming the value of the mean+2SD to be the upper limit of the normal value for each clinical variable. The results show that the adolescents, whose insulin resistance is thought to increase, showed higher IRI and CPR values of the 2-hour postload condition and Σ values compared to those of the children, but there were no differences between the 2 age groups in the values of the fasting condition, as well as in the HOMA-R values which were calculated from the fasting values. These findings indicate that there is a limitation in using fasting values to judge insulin resistance. Instead, using the 2-hour postload values and/or the Σ values is more appropriate.
Correspondence to	Correspondence to Yukashi Ohki, Department of Pediatrics, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan yukashi@nms.ac.jp