Journal of Nippon Medical School: Vol.71 No.2 page.114

Journal of Nippon Medical School

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ArticleTitle High Efficacy of Imatinib for Recurrent Gastrointestinal Stromal Tumor in the Jejunum: A Case Report

AuthorList Kimiyoshi Yokoi¹, Noritake Tanaka¹, Shoji Kyouno¹, Noriyuki Ishikawa¹, Tomoko Seya¹, Takashi Shirakawa¹, Yoshiyuki Takahashi¹, Yoshiharu Ohaki², Kiyohiko Yamashita³ and Takashi Tajiri³

Affiliation ¹Department of Surgery, Chiba-Hokusoh Hospital, Nippon Medical School
²Department of Pathology, Chiba-Hokusoh Hospital, Nippon Medical School
³The First Department of Surgery, Nippon Medical School

Language EN

Volume 71

Issue 2

Year 2004

Page 114-119

Received August25, 2003

Accepted September26, 2003

Keywords GIST, STI571, imatinib, recommended dosage, c-kit

Abstract
Gastrointestinal stromal tumor is a mesenchymal tumor of the digestive tract. Although there used to be no effective therapy for the tumor, there have been many recent reports on the efficacy of imatinib. We report on a 53-year-old female patient with a primary tumor of the jejunum who underwent 3 operations. As the tumor could not be removed at the 3rd operation, she was given imatinib orally. Results showed significant reduction ratios of the tumor area (83.0%) and volume (92.2%) at 18 months after starting imatinib administration. Also, the mean reduction ratios of the tumor area and volume per month (%/M) after starting imatinib treatment showed remarkable results, especially during the initial 3 weeks: 53.9%/M and 49.5%/M, respectively.

Whether imatinib is the first choice of treatment for GIST or not, and what is the appropriate dose and period should be resolved.

Correspondence to Correspondence to Kimiyoshi Yokoi, MD, Department of Surgery, Chiba-Hokusoh Hospital, Nippon Medical School, 1715 Kamagari, Inba-mura, Inba-gun, Chiba 270-1694, Japan
kimiyoko@nms.ac.jp

ArticleTitle	High Efficacy of Imatinib for Recurrent Gastrointestinal Stromal Tumor in the Jejunum: A Case Report
AuthorList	Kimiyoshi Yokoi¹, Noritake Tanaka¹, Shoji Kyouno¹, Noriyuki Ishikawa¹, Tomoko Seya¹, Takashi Shirakawa¹, Yoshiyuki Takahashi¹, Yoshiharu Ohaki², Kiyohiko Yamashita³ and Takashi Tajiri³
Affiliation	¹Department of Surgery, Chiba-Hokusoh Hospital, Nippon Medical School ²Department of Pathology, Chiba-Hokusoh Hospital, Nippon Medical School ³The First Department of Surgery, Nippon Medical School
Language	EN
Volume	71
Issue	2
Year	2004
Page	114-119
Received	August25, 2003
Accepted	September26, 2003
Keywords	GIST, STI571, imatinib, recommended dosage, c-kit
Abstract	Gastrointestinal stromal tumor is a mesenchymal tumor of the digestive tract. Although there used to be no effective therapy for the tumor, there have been many recent reports on the efficacy of imatinib. We report on a 53-year-old female patient with a primary tumor of the jejunum who underwent 3 operations. As the tumor could not be removed at the 3rd operation, she was given imatinib orally. Results showed significant reduction ratios of the tumor area (83.0%) and volume (92.2%) at 18 months after starting imatinib administration. Also, the mean reduction ratios of the tumor area and volume per month (%/M) after starting imatinib treatment showed remarkable results, especially during the initial 3 weeks: 53.9%/M and 49.5%/M, respectively. Whether imatinib is the first choice of treatment for GIST or not, and what is the appropriate dose and period should be resolved.
Correspondence to	Correspondence to Kimiyoshi Yokoi, MD, Department of Surgery, Chiba-Hokusoh Hospital, Nippon Medical School, 1715 Kamagari, Inba-mura, Inba-gun, Chiba 270-1694, Japan kimiyoko@nms.ac.jp