Journal of Nippon Medical School: Vol.71 No.4 page.263

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ArticleTitle Effect of Adjuvant Transarterial Infusion of Anticancer Agents after Transurethral Resection in Patients with pT2a Muscle Invasive Transitional Cell Carcinoma of the Bladder: Five and Ten-year Outcome

AuthorList Hiroyuki Shimizu, Taiji Nishimura, Go Kimura, Ichiro Matsuzawa and Yukihiro Kondo

Affiliation Department of Urology, Nippon Medical School

Language EN

Volume 71

Issue 4

Year 2004

Page 263-269

Received January 26, 2004

Accepted March 23, 2004

Keywords transurethral resection, invasive bladder cancer, intravesical instillation, chemotherapy

Abstract
Five- and ten-year survival rates in patients who had transurethral resection for pT2aN0M0 muscle invasive transitional cell carcinoma of the bladder was studied with emphasis on the effect of adjuvant transarterial infusions of anticancer agents (TAI). A total of 17 patients out of 290 patients with bladder cancer who had initial treatment in our department between January 1991 and May 2001 were found to be pT2aN0M0 and were included in the present study. Fifteen patients received intravesical instillations of BCG after transurethral resection of the bladder tumor and 8 patients received TAI which was given two weeks after bacillus Calmette-Guerin therapy, with the exception of 1 patient. Five- and ten-year overall survival rates were 76.0% and 52.1%, respectively, and both five- and ten-year cancer-specific survival rates were 76.0% with an average follow up of 71 months. Significant prognostic factor associated with survival rates was only the infiltration pattern of the tumor cells between the alpha and beta group and gamma group (P=0.0420) in cancer-specific survival rates. The data support conservative management of transurethral resection followed by intravesical instillation of BCG and TAI in patients with pT2a bladder cancer.

Correspondence to Taiji Nishimura, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

ArticleTitle	Effect of Adjuvant Transarterial Infusion of Anticancer Agents after Transurethral Resection in Patients with pT2a Muscle Invasive Transitional Cell Carcinoma of the Bladder: Five and Ten-year Outcome
AuthorList	Hiroyuki Shimizu, Taiji Nishimura, Go Kimura, Ichiro Matsuzawa and Yukihiro Kondo
Affiliation	Department of Urology, Nippon Medical School
Language	EN
Volume	71
Issue	4
Year	2004
Page	263-269
Received	January 26, 2004
Accepted	March 23, 2004
Keywords	transurethral resection, invasive bladder cancer, intravesical instillation, chemotherapy
Abstract	Five- and ten-year survival rates in patients who had transurethral resection for pT2aN0M0 muscle invasive transitional cell carcinoma of the bladder was studied with emphasis on the effect of adjuvant transarterial infusions of anticancer agents (TAI). A total of 17 patients out of 290 patients with bladder cancer who had initial treatment in our department between January 1991 and May 2001 were found to be pT2aN0M0 and were included in the present study. Fifteen patients received intravesical instillations of BCG after transurethral resection of the bladder tumor and 8 patients received TAI which was given two weeks after bacillus Calmette-Guerin therapy, with the exception of 1 patient. Five- and ten-year overall survival rates were 76.0% and 52.1%, respectively, and both five- and ten-year cancer-specific survival rates were 76.0% with an average follow up of 71 months. Significant prognostic factor associated with survival rates was only the infiltration pattern of the tumor cells between the alpha and beta group and gamma group (P=0.0420) in cancer-specific survival rates. The data support conservative management of transurethral resection followed by intravesical instillation of BCG and TAI in patients with pT2a bladder cancer.
Correspondence to	Taiji Nishimura, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan