Journal of Nippon Medical School: Vol.71 No.5 page.328

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ArticleTitle Prenatal Diagnosis of Congenital Heart Disease: Clinical Experience and Analysis

AuthorList Yoshio Shima¹, Fumiko Shindoh¹, Mizue Nakajima¹, Mari Hayakawa² and Shunnichi Ogawa²

Affiliation ¹Department of Premature and Neonatal Medicine, Japanese Red Cross Katsushika Maternity Hospital
²Department of Pediatrics, Nippon Medical School

Language EN

Volume 71

Issue 5

Year 2004

Page 328-332

Received June 11, 2004

Accepted August 2, 2004

Keywords congenital heart disease, prenatal diagnosis

Abstract Over a five-year period, we reviewed 19 fetuses who were prenatally diagnosed with congenital heart disease, including hemodynamically significant arrhythmias. Five of them had fetal tachyarrhythmias, and 14 had structural heart disease. The outcomes were: six intrauterine deaths, five neonatal deaths, and three infant surgeries. Six of the fetuses had chromosomal abnormalities, four had extracardiac anomalies, and two had hydrops fetalis. Of the 96 neonates with congenital heart disease found during the study period, the overall detection rate was 20%; 16% of the neonates with structural cardiac defects and 83% of the neonates with arrhythmias. Some of the complex cardiac defects with normal fetal four-chamber view were difficult to detect prenatally. During the course of the pregnancy, 37% of the fetuses with prenatally diagnosed congenital heart disease were found to have intrauterine growth retardation, and 26% were found to have an abnormal amniotic fluid volume. In view of our findings, a comprehensive screening system should be more frequently considered in order to improve both detection rate and perinatal management.

Correspondence to Yoshio Shima, Department of Premature and Neonatal Medicine, Japanese Red Cross Katsushika Maternity Hospital, 5-11-12 Tateishi, Katsushika-ku, Tokyo 124-0012, Japan
shima-p@nms.ac.jp

ArticleTitle	Prenatal Diagnosis of Congenital Heart Disease: Clinical Experience and Analysis
AuthorList	Yoshio Shima¹, Fumiko Shindoh¹, Mizue Nakajima¹, Mari Hayakawa² and Shunnichi Ogawa²
Affiliation	¹Department of Premature and Neonatal Medicine, Japanese Red Cross Katsushika Maternity Hospital ²Department of Pediatrics, Nippon Medical School
Language	EN
Volume	71
Issue	5
Year	2004
Page	328-332
Received	June 11, 2004
Accepted	August 2, 2004
Keywords	congenital heart disease, prenatal diagnosis
Abstract	Over a five-year period, we reviewed 19 fetuses who were prenatally diagnosed with congenital heart disease, including hemodynamically significant arrhythmias. Five of them had fetal tachyarrhythmias, and 14 had structural heart disease. The outcomes were: six intrauterine deaths, five neonatal deaths, and three infant surgeries. Six of the fetuses had chromosomal abnormalities, four had extracardiac anomalies, and two had hydrops fetalis. Of the 96 neonates with congenital heart disease found during the study period, the overall detection rate was 20%; 16% of the neonates with structural cardiac defects and 83% of the neonates with arrhythmias. Some of the complex cardiac defects with normal fetal four-chamber view were difficult to detect prenatally. During the course of the pregnancy, 37% of the fetuses with prenatally diagnosed congenital heart disease were found to have intrauterine growth retardation, and 26% were found to have an abnormal amniotic fluid volume. In view of our findings, a comprehensive screening system should be more frequently considered in order to improve both detection rate and perinatal management.
Correspondence to	Yoshio Shima, Department of Premature and Neonatal Medicine, Japanese Red Cross Katsushika Maternity Hospital, 5-11-12 Tateishi, Katsushika-ku, Tokyo 124-0012, Japan shima-p@nms.ac.jp